New Products in the PAIR® Brand Prescription Acne Medicine Line Focusing on Adult Acne and Other Skin Conditions
Lion to Release PAIR® Kampo Extract Tablets, a Herbal Medicine Effective against Recurring Premenstrual Pimple Outbreaks
Lion to Release PAIR® Acne Medicated Liquid, a Topical Medicine for Use in Treating Pimples as Soon as They Appear

Lion Corporation (President: Itsuo Hama) announced today the nationwide release on Wednesday, March 14, 2012 of PAIR® Kampo Extract Tablets—a herbal medicine primarily effective against premenstrual pimple outbreaks —and PAIR® Acne Medicated Liquid, a topical medicine for use in treating pimples as soon as they appear. These two new products are additions to the Lion PAIR® brand line of acne medicines, which focus on adult acne and other skin conditions. At the same time, Lion will rerelease PAIR® A Tablets, PAIR® A and PAIR® Acne Cream W with new and improved packaging.

1. Objective of Introducing the New Products
According to a 2011 Lion survey on adult acne among women in their 20s and 30s, 50% of respondents are concerned about recurring outbreaks of pimples in the same area of skin while 50% worried about pimples that heal poorly. However, with only 47% of those surveyed expressing satisfaction with the acne treatments currently available, it is clear that the majority of respondents are dissatisfied. In addition, when asked about the times that adult acne most often occurs, “just prior to menstruation” was the response of 57% of women—a far greater number than those who report suffering from acne while under stress or when tired.

Lion will release PAIR® Kampo Extract Tablets, a herbal medicine that provides effective relief from within the body primarily against premenstrual adult acne outbreaks. Lion will also release PAIR® Acne Medicated Liquid—a topical medicine for treating pimples as soon as they appear—to meet the needs of the 96% of concerned women who want an immediate solution to their adult acne.

At the same time, Lion will rerelease the following PAIR® brand products with new and improved package designs: PAIR® A Tablets oral tablet-type medicine and PAIR® A drink-type medicine, which promote increased metabolism and waste material removal in order to effectively treat recurring pimple outbreaks caused by disruptions in one’s daily routine; and PAIR® Acne Cream W, a topical, medicated cream that provides effective relief from inflamed and red pimples.

Lion will expand the PAIR® brand of effective acne medicines through the addition of PAIR® Kampo Extract Tablets oral medicine and PAIR® Acne Medicated Liquid topical medicine, both of which meet the needs of women who are concerned about adult acne.
PAIR® Kampo Extract Tablets PAIR® Acne Medicated Liquid PAIR® A Tablets PAIR® A PAIR® Acne Cream W
PAIR® Kampo Extract Tablets PAIR® Acne Medicated Liquid PAIR® A Tablets PAIR® A PAIR® Acne Cream W

2. Product Features, Active Ingredients, Indications and Effects, Directions and Doses

PAIR® Kampo Extract Tablets, a herbal medicine effective against recurrent premenstrual pimples and blemishes

(1) Product features
1. Features keishi-bukuryo-gan, a blend of five herbal medicines that improve blood flow
Blended with five herbal medicines (cinnamon bark, Poria sclerotium, moutan bark, peach kernel and Paeonia albiflora), keishi-bukuryo-gan is an effective herbal treatment for acne and blemishes. Consequently, keishi-bukuryo-gan treats from within the body pimples and blemishes caused mainly by hormone imbalances. In addition, this herbal medicine improves blood flow to display superior effectiveness in treating stiff shoulders, menstrual cramps and irregular menstruation.

According to an epidemiological report, hormone imbalances are a cause of premenstrual acne.
PAIR® Kampo Extract Tablets
2. In addition to keishi-bukuryo-gan, which is extracted from five types of herbal medicines (accounting for 2/3 the product amount), PAIR® Kampo Extract Tablets are blended with a variety of crude drug powders.
3. Dosage: four pills twice per day. PAIR® Kampo Extract Tablets feature easy-to-swallow tablets for those who dislike the distinctive taste of crude drugs.
4. The package design expresses the superior effectiveness of PAIR® Kampo Extract Tablets

(2) Active Ingredients Contained in Eight Tablets (Daily Dosage)
Keishi-bukuryo-gan (accounting for 2/3 the product amount) 1,533mg
(extracted from 2.67g of cinnamon bark, Poria sclerotium, moutan bark, peach kernel and Paeonia albiflora)
Cinnamon bark powder 100mg
Poria sclerotium powder 100mg
Moutan bark powder 100mg
Peach kernel powder 100mg
Paeonia albiflora powder 100mg

(3) Indications and Effects
For relatively healthy adults who suffer from periodic abdominal pain, stiff shoulders, heavy headedness, dizziness and cold feet, this medicine alleviates the following symptoms: acne, eczema/dermatitis, blemishes, menstrual cramps, irregular or abnormal menstruation, menopause, menstrual disorders1, bruises and frostbite
1. Menstrual disorders: Neurological and physical symptoms that include nervousness and irritation caused by hormonal changes during the menstrual cycle, pregnancy, childbirth, post-childbirth, menopause, etc.

(4) Directions and Doses
Adult (15 years and older): four tablets per dose, twice per day before meals or with cold or lukewarm water between meals


PAIR® Acne Medicated Liquid, a topical medicine that treats pimples as soon as they appear by softening dead skin cells

(1) Product Features
1. Blended with three active ingredients, PAIR® Acne Medicated Liquid treats pimples as soon as they appear.
Salicylic acid skin-softening agent: softens hard dead skin cells and unclogs pores
Isopropyl methylphenol (IPMP) antibacterial agent: kills propionibacterium acnes and other bacteria that worsen acne symptoms, thereby inhibiting pimple formation
Allantoin anti-inflammatory agent: relieves pimple inflammation
PAIR® Acne Medicated Liquid
2. Offers concentrated acne treatment without the need to change one’s regular skin care routine
A non-sticky liquid that is applied to pimples using a cotton bud or other similar material, PAIR® Acne Medicated Liquid makes it possible to continue one’s regular skin care routine and can be used under makeup.
3. Features a mild formula that is easy to use for adults who suffer from sensitive and/or dry skin
4. The package design expresses the superior effectiveness of PAIR® Acne Medicated Liquid

(2) Active Ingredients
Salicylic acid 0.5%
IPMP 0.3%
Allantoin 0.2%

(3) Indications and Effects
Acne 

(4) Directions and Doses
Twice per day (morning and evening), apply an adequate amount to a cotton bud or absorbent wadding, gauze, etc., and hold on the affected area of skin for approximately two to three minutes


PAIR® A Tablets, an oral tablet-type medicine that effectively treats repeated outbreaks of acne and rough skin caused by disruptions in one’s daily routine

(1) Product Features
1. Focus on waste buildup;2 formulated to effectively treat repeated outbreaks of acne and rough skin
Glucuronolactone helps liver function and counteracts the waste poisons that have accumulated in the body, helping to drain them
Coix seed, or pearl barley, is a crude drug that effectively treats acne, rough skin and inflammation by helping control sebum secretions and skin moisture.
Contains the maximum dose3 of vitamins B2 and B6 to regulate skin cell turnover
Vitamin B2 controls excess production of sebum and normalizes fat metabolism, while Vitamin B6 normalizes protein metabolism.

2. A cause of adult acne (old skin cells, sebum, etc.)
3. Approval standards for the manufacture and sale of general-purpose vitamins and major drug formulations
L-Cysteine, an amino acid that builds skin cells, contributes to energy metabolism and helps skin turnover
PAIR® A Tablets
2. One tablet, twice per day; small, easy-to-swallow, coated tablets
3. The package design expresses the superior effectiveness of PAIR® A Tablet

(2) Active Ingredients
Glucuronolactone 200mg
Coix seed extract 77mg (equivalent to 1,001mg of crude drugs)
L-Cysteine 30mg
Riboflavin phosphate (Vitamin B2) 30mg
Pyridoxine hydrochloride (Vitamin B6) 100mg

(3) Indication and Effects
Alleviation of the following symptoms: acne, rough skin, skin inflammation, skin rashes, soreness, eczema, canker sores, angular cheilitis, cheilitis and glossitis (If symptoms do not improve after one month of continued use, please consult a doctor or a pharmacist.)
Vitamins B2 and B6 supplementation in the following cases: physical exhaustion, weakness during pregnancy and when nursing, weakness during and after illness

(4) Directions and Doses
Adult (15 years and older): one tablet twice per day (morning and evening)


PAIR® A, a drink-type medicine that provides quick and effective relief from repeated outbreaks of acne and rough skin caused by disruptions in one’s daily routine

(1) Product Features
1. Improves acne and rough skin from the inside
A highly effective treatment containing five active ingredients (glucuronolactone, coix seed, nicotinic acid amide, vitamins B2 and B6)
Glucuronolactone helps liver function and counteracts the waste poisons that have accumulated in the body, helping to drain them
Coix seed, or pearl barley, is a crude drug that effectively treats acne, rough skin and inflammation by helping control sebum secretions and skin moisture.
Nicotinic acid amide helps improve metabolic function 
Vitamins B2 and B6 are both effective in helping maintain skin cell turnover. Vitamin B2 controls excess production of sebum and normalizes fat metabolism, while Vitamin B6 normalizes protein metabolism.
PAIR® A
2. Refreshing and easy to drink
Acerola flavored drink with a refreshing aftertaste. Only 12 kcal per bottle and no caffeine content allows for easy drinking before bedtime.
3. The package design expresses the superior effectiveness of PAIR® A

(2) Active ingredients contained in one 50ml bottle
Glucuronolactone 300mg
Coix seed extract 230.8mg (equivalent to 3,000mg of crude drugs)
Nicotinic acid amide 60mg
Riboflavin phosphate (Vitamin B2) 38mg
Pyridoxine hydrochloride (Vitamin B6) 100mg

(3) Indications and Effects
Alleviation of the following symptoms: acne, rough skin, angular cheilitis, cheilitis, canker sores, glossitis, eczema, skin inflammation, skin rashes and soreness (If symptoms do not improve after one month of continued use, please consult a doctor or a pharmacist.)
Vitamins B2 and B6 supplementation in the following cases: physical exhaustion, weakness during pregnancy and when nursing, weakness during and after illness

(4) Directions and Doses
Adult (15 years and older): one bottle (50ml) per day


PAIR® Acne Cream W, a topical, medicated cream effective against red, inflamed acne

(1) Product Features
1. The double formula consisting of the anti-inflammatory agent ibuprofen piconol (IPPN) and the antibacterial agent IPMP helps treat skin eruptions and acne at its source.
IPPN features superior anti-inflammatory effectiveness to treat skin eruptions and acne at its source by controlling the formation of whiteheads and inhibiting inflamed, red pimples caused by propionibacterium acnes
IPMP kills propionibacterium acnes and other bacteria that exacerbate acne symptoms, thereby inhibiting rough skin and acne formation
PAIR® Acne Cream W
2. The cream becomes transparent when spread thinly over the affected area, so it can be used with makeup.
Thanks to the non-sticky cream that is easily absorbed by the skin, PAIR® Acne Cream W is well suited for use after washing one’s face in the morning and evening, and it can be used without concern during the day or when going out.
3. The package design expresses the superior effectiveness of PAIR® Acne Cream W

(2) Active Ingredients
IPPN 3.0%
IPMP 0.3%

(3) Indication and Effects
Skin eruptions, acne 

(4) Directions and Doses
Apply an appropriate amount of the cream to the affected area several times a day after first washing with soap


4. Contents and Prices
Product nameContentsSuggested retail price
(per unit)
PAIR® Kampo Extract Tablets
(type-2 drug)
112 tablets ¥ 2,180
240 tablets ¥ 4,200
PAIR® Acne Medicated Liquid
(type-2 drug)
120ml ¥ 1,480
PAIR® A Tablets (type-3 drug)   60 tablets ¥ 1,440
120 tablets ¥ 2,700
PAIR® A (type-3 drug)  50ml ¥ 260
50ml x3 ¥ 780
PAIR® Acne CreamW (type-2 drug) 14g ¥ 950
24g ¥ 1,450
Suggested retail price is before tax.
Bold items are new products.

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