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New Product Information
October 6, 2009

Lion Releases BUFFERIN PLUS S, an Antipyretic Analgesic Formula with Superior, Fast-Acting Effectiveness for Intense Headaches and Fevers
Lion Corporation (President: Sadayoshi Fujishige) announced today the release to pharmacies nationwide of BUFFERIN PLUS S on Wednesday, October 22, 2009. Utilizing Lion’s proprietary rapid-dissolving tablet technology, FASTab*, this antipyretic analgesic formula features superior, fast-acting effectiveness for intense headaches and fevers.

BUFFERIN PLUS S

1. Objective of Introducing the New Product
According to a Lion survey conducted in December 2008, 70% of people who use antipyretic analgesics are women, with females in their 30s constituting the largest group, at 25%. In contrast to women in their 20s—who take antipyretic analgesics primarily to control menstrual pain—those in their 30s use such products to relieve headaches. This indicates that the symptoms for which antipyretic analgesics are used changes when women reach their 30s. Moreover, women in this age group look for medications that that are fast acting (66%), are effective against headaches (62%) and place a minimum burden on the stomach (56%).
 
Consequently, Lion has responded to the need for medications that are fast acting, feature superior effectiveness against headaches and are mild on the stomach by releasing BUFFERIN PLUS S. This product is an antipyretic analgesic that is blended with four pain-relieving ingredients and a component that protects the stomach’s gastric mucosa, taking advantage of Lion’s proprietary, rapid-dissolving tablet technology, FASTab.
 
Through the release of BUFFERIN PLUS S, Lion is lending its support to consumers who lead positive and hardworking lives, even when suffering from severe headaches.
 

2. Product Features

【Point 1: Fast Acting】
Thanks to the use of Lion’s proprietary, rapid-dissolving tablet technology, FASTab, tablets break down with greater speed, dispersing active ingredients that are effective against headaches and fevers.

Through an optimal blend of hydrophilic particles and disintegrating agents, superior tablet dissolvability is achieved (Process patent No. 4329947, internal-use tablets). Consequently, tablets dissolve quickly to disperse active ingredients that are effective against headaches and fevers with greater speed.

*FASTab: An abbreviation for Fine Assembled Tablet

【Point 2: Superior Effectiveness for Intense Headaches and Fevers】
BUFFERIN PLUS S features two antipyretic analgesic ingredients—acetylsalicylic acid and acetaminophen—as well as two secondary pain relief ingredients—allylisopropyl acetylurea and anhydrous caffeine.

Acetylsalicylic acid, which goes to the root of pain found in the peripheral nerves, and acetaminophen, which concentrates on the central nervous system—where pain is transmitted—are both highly effective for relieving pain. In addition, allylisopropyl acetylurea provides a sedative effect, while anhydrous caffeine is effective in constricting blood vessels. Consequently, both of these ingredients help to relieve pain.

【Point 3: Mild on the Stomach】
This product is blended with the ingredient, dried aluminum hydroxide gel, which protects gastric mucosa that forms the lining of the stomach.

3. Active Ingredients (per tablet)
Acetylsalicylic acid (antipyretic analgesic ingredient that reduces fevers and relieves pain) 250mg
Acetaminophen (antipyretic analgesic ingredient that reduces fevers and relieves pain) 150mg
Anhydrous caffeine (secondary ingredient that relieves pain) 60mg
Allylisopropyl acetylurea (secondary ingredient that relieves pain) 15mg
Dried aluminum hydroxide gel (protects gastric mucosa) 35mg

4. Efficacy

(1)
Pain relief for headaches, menstrual pain, stiff shoulders, lumbar pain, toothaches, tooth loss, muscular pain, joint pain, pain from bruises and wounds, pain from sprains and breaks, ear aches and sore throats

(2) Reduces fever and chills

5. Directions for Use and Dosage

15 years and older: 2 tablets to a maximum of twice per day
Avoid taking on an empty stomach, and wait 6 hours before taking again

6. Contents and price
Product name Contents Retail price
BUFFERIN PLUS S
(Pharmaceutical)
 
24 tablets ¥ 1,080
48 tablets ¥ 1,880
* Recommended retail price before tax.

Reference Document

■ Lion’s proprietary rapid-dissolving tablet technology, FASTab
Lion’s proprietary rapid-dissolving tablet technology, FASTab
Through the action of the hydrophilic particles contained within the tablets, tablet contents rapidly dissolve in water. Then, active ingredients disperse rapidly due to disintegrating agents, which absorb water and quickly expand, dissolving the tablet from the inside.


The amount of time for BUFFERIN PLUS S tablets to completely dissolve using FASTab technology
The amount of time for BUFFERIN PLUS S tablets to completely dissolve using FASTab technology
Compared with tablets that do not use FASTab technology (right), tablets that use FASTab technology (left) dissolve more quickly.


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