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Research Accomplishments : 2019

Oral Technology

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports (2019) 9:16124 |
    2019/11/6
    Ryutaro Jo1), Yuichiro Nishimoto2), Kouta Umezawa3), KazumaYama1), YutoAita1), Yuko Ichiba1), Shinnosuke Murakami2),4), Yasushi Kakizawa1), Takashi Kumagai3), TakujiYamada2),5),6) Shinji Fukuda2),4),6),7),8)
    1) Research and Development Headquarters, 2) Metabologenomics, Inc.,3) Hiyoshi Oral Health Clinics. ,4) Institute for Advanced Biosciences, Keio University, 5) Department of Life Science and Technology, Tokyo Institute of Technology, 6) PRESTO, Japan Science and Technology Agency, 7) Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8) Transborder Medical Research Center, University of Tsukuba
  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics
    2019/10/15-10/19
    Satoshi Morishita
  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research volume 26, Article number: 246 (2019)
    2019/9/12
    Ryosuke Hachisuka1),2), Toshiaki Kobayashi3), Masayuki Yamaguchi2)
    1) School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters, Lion Corporation, 3) The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)
  • A New Method to Speculate Halitosis Level Using Machine Learning

    International Association for Dental Research (IADR)
    2019/6/19-6/22
    Chiaki Michibayashi
  • Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts — in vitro study

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27
    2019/03/29
    Naho Suzuki
  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports (2019) 9:16124 |
    2019/3/5
    Takuya Hayakawa1), Shizuka Kawasaki1), Yutaka Hirayama1),TakuyaTsutsui1), Eiji Sugiyama2), KiyoAdachi1), Ryo Kon1), Makoto Suematsu2), Yuki Sugiura2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Biochemistry, Keio University School of Medicine

Interface Technology

  • Micellar Effects on the Hydrolysis Reaction of an Anionic Surfactant in Aqueous Solution and Measurements of Adsorbed Proton on the Micellar Surface.

    The 70th Divisional Meeting of Divison of Colloid and Surface Chemistory 2019
    2019/11/3-11/4
    Miyuki Miyake
  • Developing New Methyl Ester Ethoxylate with Long Alkyl Chain Length

    The 58th Annual Meeting of the Japan Oil Chemists’ Society
    2019/9/24-9/26
    Akinori Joko
  • Development of novel eye drops by applying the permeability of vitamin nanoemulsions into corneal cell

    The 71st Society for Biotechnology, Japan/Annual Meeting
    2019/9/16-9/18
    Miyuki Miyake
  • Developing New Methyl Ester Ethoxylate Derived from C18 Fraction of Palm Oil for Liquid Laundry Detergent

    CESIO 11th world surfactant congress (2019)
    2019/6/3-6/5
    Sho Tsujimura
  • Homogenized Bimetallic Catalysts from Metal-Organic Framework Alloys

    Chemistry of Material. 2019, 31, 11, 4205–4212
    2019/3/22
    Jet-Sing M. Lee1), Yu-ichi Fujiwara2), Susumu Kitagawa1), Satoshi Horike1),3),4),5)
    1) Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, 2) Research & Development Headquarters, LION Corporation, 3) AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory (ChEM-OIL), Kyoto University, 4) Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 5) Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology

Environment and Human Safety

  • Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice

    Journal of Chromatography B Volume 1137
    2019/11/25
    KanakoYuyama1), YoshitakaNakamura1), RihoTateyama1), RiekoArakaki2), TakuyaTsutsui1), NaozumiIshimaru2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences
  • The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

    Journal of Applied Toxicology Volume39, Issue11 November 2019 Pages 1492-1505
    2019/7/17
    Masaharu Fujita1), Yusuke Yamamoto1), Shinichi Watanabe2), Tsunetsugu Sugawara2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kei Kusakari5), Yoshihiko Kurokawa5), Tsuyoshi Kawakami6), Kohichi Kojima7), Takashi Sozu8), Takuto Nakayama8),Takeru Kusao8), Jon Richmond9), Kleinstreuer Nicole10), Bae-Hwa Kim11), Hajime Kojima12), Toshihiko Kasahara1), Atsushi Ono13)
    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc, 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Dr. Jon Richmond: Advice and Consultancy,10) NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, 11)College of Natural Sciences Keimyung University,12) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 13) Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University
  • Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human Buccal Mucosal Model — Study on Setting of Oral Mucosal Irritation Evaluation Flow for Raw Materials and Products for Oral Care —

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
    2019/6/26-6/28
    Seiya Aizawa
  • Development of ADRA-OS (Organic solvent reaction System) for poorly water-soluble sensitizers

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
    2019/6/26-6/28
    Hiroaki Yamaga

Life Sciences Technology

  • The effects of sleep quality measurement and sleep care solution on health promotion and work productivity improvement.

    The 15th Japanese Society of Fatigue Science
    2019/5/18-5/19
    Yuki Nagamori

Living and Fabric Care

  • Design of nanoscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    Chemical Engineering Science volume 203 (2019) page 113–121.
    2019/3/27
    Motoyuki Iijima1),2), Masahiro Hayakawa2), Junichi Tatami1),2), Koichiro Nakamura3), Shinichi Nagashima3)
    1) Faculty of Environment and Information Sciences, Yokohama National University, 2) Graduate School of Environment and Information Sciences, Yokohama National University, 3) Research and Development Headquarters, Lion Corporation
  • Current Status and Control of Microbiological Contamination in Indoor Environment Mold Pollution and Control in the Bathroom

    JOURNAL OF ANTIBACTERIAL AND ANTIFUNGAL AGENTS, JAPAN, Vol.47, No.6, pp.233−237 (2019)
    Hiroshi Yamagishi

Medicated Care

  • Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

    PLoS One. 2019 Nov 6;14(11):
    2019/11/6
    Tetsuhiro Shimodaira1), Shigeo Mikoshiba1), Toru Taguchi2),3)
    1) Lion Corporation, 2) Department of Physical Therapy, Niigata University of Health and Welfare, 3) Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare
  • The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing

    YAKUGAKU ZASSHI 140, 91 97 (2020)
    2019/10/25
    Miu Kitahara,Keiko Seki, Tatsuyuki Midorikawa, Junya Arita, and Akira Uchiyama
    Research & Development Headquarters, Lion Corporation

Body Care

  • Rooibos extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulate the M3 muscarinic acetylcholine receptor

    The 7th International Conference on Food Factors
    2019/12/1-12/5
    Takao Iwai
  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    Eur J Pharm Biopharm. 2020 Jan;146:10-18
    2019/11/16
    Takumi Mitsudome1), Mitsutoshi Moribe1),Yoshiyuki Obayashi1), Akira Uchiyama1), Megumi Aono1)
    1) Research & Development Headquarters, Lion Corporation
  • Rooibos extract activates M3 muscarinic acetylcholine receptor and relieves human dryness

    The 29th Annual Meeting of the Japanese Society of Oral Medicine
    2019/9/20-9/23
    Takao Iwai
  • In vivo mechanism study on the dryness relief function of rooibos extract

    The 29th Annual Meeting of the Japanese Society of Oral Medicine
    2019/9/20-9/23
    Takao Iwai
  • Effects of Rooibos (Aspalathus linearis) Extract on Dryness of Mouth, Eye and Skin in Human

    The 28th Annual Meeting of the Japanese Society for Sjögren’s syndrome
    2019/9/13-9/14
    Takao Iwai
  • Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice

    Journal of Oral Biosciences Volume 61, Issue 3, September 2019, Pages 179-182
    2019/8/7
    Rieko Arakaki1), Aya Ushio1), Satoru Kisoda1), Mami Sato1), Yoshitaka Nakamura2), Kanako Yuyama2), Riho Tateyama2), Satoru Morishita2), Noriyuki Monoi2), Yasusei Kudo1), Naozumi Ishimaru3)
    1) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences, 2) Research & Development Headquarters, Lion Corporation, 3) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences
  • Exercise and sports health claims in the system of Foods with Function Claims

    The 19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
    2019/6/14-6/16
    Mitsuru Nomura
  • Rooibos (Aspalathus linearis) extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulates exocrine glands via the M 3 muscarinic acetylcholine receptor

    Journal of Functional Foods Volume 55, April 2019, Pages 248-254
    2019/2/7
    Saori Nishimachi1),Takao Iwai1), Yoshitaka Nakamura1), Kanako Yuyama-Masuda1), Takuya Tsutsui1),Noriyuki Monoi1), Akira Uchiyama1),2), Seiji Nakamura3)
    1) Research & Development Headquarters, Lion Corporation, 2) Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, 3) Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
  • A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration

    BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2019, VOL. 83, NO. 10, 1851–1857
    2019/1/4
    Satoko Sato1), Mitsuru Nomura1), Ikko Yamana1), Akira Uchiyama1), Yasuro Furuichi2), Yasuko Manabe2), Nobuharu L Fujii2)
    1) Research and Development Headquarters, Lion Corporation, 2) Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University

Product Process Technology

  • Recent trend in water reuse technology “Recycling of Wastewater from the Manufacturing Process of Toiletry Products”

    The 22nd JSWE Symposium
    2019/9/5-9/6
    Yoshio Shimizu

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