Research Accomplishments : 2020

Oral Technology

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology
    Reona Noda, Shizuka Kawasaki, Ryosuke Hachisuka
  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    Japanese Society for Oral Health
    Koichiro Hayashi
  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    Japan Academy of Esthetic Dentistry
    Ryota Hashimoto
  • Development of “RePERO”, an application to support breath care

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan
    Kengo Oka
  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration
    Kenichiro Shibasaki
  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science
    Yuya Kimoto
  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The Japanese Society of Conservative Dentistry
    Rika Oda
  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    the 63rd Spring Meeting of the Japanese Society of Periodontology
    Kenji Egashira
  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    Japanese Society of Pediatric Dentistry
    Mai Satake
  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research (IADR) 2020
    Tsuguno Yamagushi
  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University
    Eiji Nishinaga
  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

Interface Technology

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubule

    Japan Oil Chemicals’ Society
    Miyuki Miyake
  • Purpose of establishment and activities of the “Social Health Strategy Research Institute” aiming to improve social health and realize a sustainable symbiotic society

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan
    Miyuki Miyake

Aroma Technology

  • Extraction and Analysis Method of Fragrance in High Concentration Surfactant

    Symposium on the Chemistry of Terpenes, Essential oils and Aromatics
    Keita Sawada

Environment and Human Safety

  • Introduction of EpiSensA, an alternative method for skin sensitization test using 3D human epidermis model, for evaluation of poorly water-soluble substances

    The Japanese Society for Alternatives to Animal Experiments
    Junko Ueno
  • Case studies of microbial problems in the manufacturing genba of cosmetics and personal care products

    Fragrance journal : Research & development for cosmetics, toiletries & allied industries  48(5), 53-64, 2020-05
    Masahiko Otani
  • New approach to evaluation and classification of irritation intensity of oral care ingredients using a three-dimensional human buccal mucosal model.

    Society of Toxicology Annual Meeting
    Joint research with Kao Corporation and Sunstar Corporation
  • Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

    Jounal of Applied Toxicology, 2020;40:843-854
    Miyuki Akimoto1), Yusuke Yamamoto1), Shinichi Watanabe2), Hiroaki Yamaga2), Kousuke Yoshida2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), | Kei Kusakari5), Kohei Kamiya5), Kohichi Kojima6), Tsuyoshi Kawakami7), Hajime Kojima8), Atsushi Ono9), Toshihiko Kasahara1), Masaharu Fujita1)
    1) Fujifilm Corporation, Safety Evaluation Center, 2) Lion Corporation, 3) Mitsui Chemicals, Inc. Chemical Safety Department, 4) Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory, 5) Nissan Chemical Corporation, Biological Research Laboratories, 6) Food and Drug Safety Center, Hatano Research Institute, 7) Division of Environmental Chemistry, National Institute of Health Sciences, 8) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 9) Okayama University

Analysis Technology

  • Basic knowledge of microorganisms and introduction of antibacterial and antiviral measures

    Seiichi Tobe
  • Contribution to the development work of functional foods using LC-MS technology

    The Japan Society for Analytical Chemistry
    Atushi Satoh

Life Sciences Technology

  • BtoBtoC business that aims to improve health and work productivity through better sleep.

    Kenkojumyo Report
    Aono Megumi
  • Influence of remote working on sleep during COVID-19 pandemic

    Japanese Society for Chronobiology
    Takahiko Suiko
  • Improving Worker Productivity and Workplace Safety by Measuring Sleep Quality and Suggesting Sleep Improvement Methods

    Japan Society for Occupational Mental health
    Takuya Ichinose
  • Creating a New Value of Sleep Health Care; A Healthy Body Provided by Good Sleep

    Japanese Cosmetic Science Society
    Tomomi Sano
  • Effects of muscle contraction on metabolomic profiling using in vitro exercise model

    the Japan Society for Bioscience, Biotechnology and Agrochemistry
    Satoko Satoh
  • Effects of lutein and astaxanthin intake on the improvement of cognitive functions among healthy adults: a systematic review of randomized controlled trials

    Rui Nouchi1),2), Takahiko Suiko3), Eriko Kimura3), Hiroki Takenaka3), Michiaki Murakoshi3), Akira Uchiyama3), Megumi Aono3), Ryuta Kawashima2),4)
    1) Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC),Tohoku University, 2) Smart Aging Research Center (S.A.R.C.), Tohoku University, 3) Research and Development Headquarters, Lion Corporation, 4) Department of Functional Brain Imaging, In
  • Social Implementation Relay "Efficacy of Sleep Check & Care and Efforts at Hirosaki COI

    HealthyAging Innovation Summit
    Megumi Aono
  • Purpose of establishment and activities of the “Social Health Strategy Research Institute” aiming to improve social health and realize a sustainable symbiotic society

    Healthcare IT 2020
    Megumi Aono

Living and Fabric Care

  • Efforts to increase awareness of laundry methods using QR codes

    Symposium on Cleaning
    Yuki Saito
  • Introduction to Commodities and Services by Means of Up-to-date Technological Studies by Companies Development of “Anti-Smelling Top Super NANOX”

    The Japan Research Association for Textile End-Uses
    Keisuke Mori
  • Efforts with apparel manufacturers to raise awareness of washing methods

    The Japan Reseach Association for textile end-uses
    Yuki Saito
  • Visualization of skin texture - Performance evaluation of detergents for clothing by X-ray CT

    Rigaku Jounal
    Yukari Sekine

Medicated Care

  • Comparison of the drug efficacy of OTC antipyretic analgesic ingredients using a mouse model of tension-type headache

    Japanese Association for Study of Pain
    Yuki Ogawa
  • Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells

    Journal of Ocular Pharmacology and TherapeuticsVol. 36, No. 9
    Kyohei Kabashima1), Akira Murakami2), Nobuyuki Ebihara3)
    1) Lion Corporation Odawara Research Center, 2) Department of Ophthalmology, Juntendo University Graduate School of Medicine, 3) Department of Ophthalmology, Juntendo University Urayasu Hospital
  • Creation of a rat model of functional dyspepsia with chronic downregulation of tight junction component proteins

    the Japanese Society of Ulcer Research
    Mayumi Tsuri, Takuya Hayakawa
  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

    Heliyon, Volume 6, Issue 5, May 2020
    Mizuho Niibori1),Yasushi Kudo1),Takuya Hayakawa1), Keiko Ikoma-Seki Ryosuke Kawamata1), Atsushi Sato1), Kazue Mizumura2),3)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Physiology, Nihon University School of Dentistry, 3) College of Life and Health Sciences, Chubu University
  • The Effect of Nonpolar Lipids in Meibum on Stability of Tear Film Lipid Layer against Compression-Expansion Cycles

    Journal of Oleo Science. 2020
    Masataka Yoshida1), Masato Yamaguchi2), Atsushi Sato1), Miyuki Miyake1), Nobuhito Tabuchi1), Ryo Kon1), and Ken-ichi Iimura3)
    1) Research and Development Headquarters, Lion Corporation, 2) Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 3) Division of Engineering and Agriculture, Graduate School of Regional Development and Creativity, Utsunomiya University

Body Care

  • Technology Introduction of “Nice Slim Essence Lactoferrin” to be delivered to the intestines —Visceral Fat Reduction Mechanism and Enteric Coating Technology—

    Japanese Association for lactferrin
    Takumi Mitsudome
  • Ideas for preventing infections in the home and workplace, hand washing and cleaning

    Japan Oil Chemicals’ Society
    Yukari Sekine
  • Application of Anionic Polymers in Cosmetics

    COSMETIC STAGE Vol.15, No.1 2020
    Tomoki Sano
  • Intraoral Approach to Improve the Nasolabial Fold

    Cosmetic stage 14(6), 39-45, 2020-08
    Yujiro Endo
  • Washing the skin.

    Japanese Dermatological Association
    Hotaka Asano
  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2020
    Takumi Mitsudome
  • Foot trouble due to sweat and odor and development of corresponding products

    FRAGRANCE JOURNAL 2020 No.477 (Vol.48/No.3)
    Shinichi Nagashima
  • Effect of lactoferrin intestinal solvent on visceral fat reduction

    Functional Food
    Michiaki Murakoshi, Kanae Nakamura, Tomoji Ono
  • Enteric-coated lactoferrin decreases abdominal visceral fat in humans: a randomized, double-blind, placebo-controlled, parallel-group study

    Jpn Pharmacol Ther 2020 : 48 : 1179-85
    Satoko Sato1), Mitsuru Nomura1), Akira Uchiyama1), Ikuo Fukuhara2)
    1) Research & Development Headquarters, Lion Corporation, 2) Fukuhara Clinic, Eniwa
  • Effects of Coexistent Components on the Antiperspirant Action of Aluminium Chlorohydrate

    J. Soc. Cosmet. Chem. Jpn. 55 (1): 45-51
    Tomoki Sano, Wataru Shirae, Yuriko Omoto, Shinichi Nagashima, Atsunori Morigaki, Yasushi Kakizawa, Takaki Ikenishi
    Research & Development Headquarters, Lion Corporation
  • A Study on a Longitudinal Evaluation Method Using Facial Expression Analysis to Capture Emotional Changes during Cosmetics Use

    The Japanese Society for Cognitive Psychology
    Eisuke Inagaki


  • Health management and work style reform that is resilient to social change

    Social Health Strategy Research Institute
    Megumi Aono