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Research Accomplishments : 2021

Oral Technology

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health
    2021/12/21-12/23
    Yukari Sekine
  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health
    2021/12/15
    Shinsuke Kataoka1), Mitsuo Kimura1),Tsuguno Yamaguchi1), Kenji Egashira1),Yu Yamamoto1), Yasushi Koike1),Yuki Ogawa1), Chika Fujiharu2), Toshiko Namai2), Kanako Taguchi2), Momoko Takahashi2), Asami Kameda2), Tomoka Kasen2),Asami Hano2), Konomi Kubota2),Masayuki Sato1), Hiroaki Yamaga1), Kaori Nohara2), Mikiko Shirasawa2), Chika Sekine2), Maki Fukuda2), Arisa Aoki2),Yurina Takeuchi2), Misaki Mugiyama2), Kenta Mori4), Keigo Sawada 4) Yoichiro Kashiwagi4), Masahiro Kitamura4), Takeshi Hayashi3),Tohru Nakagawa3), Shinya Murakami4)
    1) Research & Development Head Quarters, LION Corporation,2) The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3) Hitachi Health Care Center, Hitachi Limited,4) Faculty of Dentistry, Osaka University
  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The Japanese Society of Conservative Dentistry
    2021/10/28-11/10
    Masakazu Ono
  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    Japanese Society of Pediatric Dentistry
    2021/10/17-10/23
    Ryosuke Hachisuka
  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64st Autumn Meeting of the Japanese Society of Periodontology
    2021/10/15-10/16
    Yu Yamamoto
  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Yama Kazuma
  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Riho Makino
  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Mari Yutori
  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Taku Iwamoto
  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Yukihide Aoyama
  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Yasushi Koike
  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Kota Tsutumi
  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE
    2021/9/17
    Riho Tateyama-Makino1), Mari Abe-Yutori1), Taku Iwamoto1), Kota Tsutsumi1), Motonori Tsuji2),Satoru Morishita1), Kei Kurita1), Yukio Yamamoto1), Eiji Nishinaga1),Keiichi Tsukinoki3)
    1) Research & Development Headquarters, Lion Corporation, 2) Institute of Molecular Function, 3) Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University
  • Survey on oral care habits and halitosis among general community residents

    Annual Meeting of the Japanese Society for Oral Health Care
    2021/4/17-4/18
    Chiyoko Uchiyama
  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The Chemical Society of Japan
    2021/3/19-3/21
    Mari Yutori
  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The Chemical Society of Japan
    2021/3/19-3/21
    Riho Makino
  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)
    2021/3/11
    Chika Akabane1),2), Silvia Pabisch2), Wolfgang Wagermaier2), Andreas Roschger2),3), Norio Tobori1), Tomomichi Okano1). Shinya Murakami4), Peter Fratzl2), Richard Weinkamer2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3) Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4) Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan
  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports volume 11:861 (2021)
    2020/1/13
    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki
    Research and Development Headquarters, Lion Corporation
  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    Engineering Research Express, Volume 3.
    2021/1/11
    Ryosuke Hachisuka1),2), Reona Noda2), Masayuki Yamaguchi1)
    1) School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation
  • Basic study on staining and removal of dentin by various beverages

    Japanese Society for Oral Health
    Ayaka Iwasaki

Interface Technology

  • Structural Analysis of Nanoparticles and Gel Networks Formed by Chlorohydroxyaluminum by Small- and Wide-Angle X-ray Scattering

    Division of Colloid Surface Chemistry
    2021/9/15-9/17
    Sachiko Takano
  • Enhancement of Virus Inactivation of Cationic Surfactants by Sulfate Ions

    Japan Oil Chemicals’ Society
    2021/9/6-9/11
    Rei Saito
  • Dispersion stabilization of fragrance capsules in fabric softeners - Viscoelasticity control in vesicle systems based on depletion aggregation

    Japan Oil Chemicals’ Society
    2021/9/6-9/11
    Asami Miyajima
  • Synergistic effects of surfactants and chelating agents on tightly adherent keratin for simple cleaning

    Japan Oil Chemicals’ Society
    2021/9/6-9/11
    Shinya Sudo
  • Permeation Behavior of Liposoluble Substances Solubilized in Bile Salts/Phospholipid Mixture Micelles through Biological Membrane Models

    Japan Oil Chemicals’ Society
    2021/9/6-9/11
    Sara Isurugi

Aroma Technology

  • Analysis of Brain Activity Related to Fragrance Preference of Fabric Softener for Clothes

    The Japanese Association for the Study of Taste and Smell
    2021/10/19-10/21
    Kai Saito

Environment and Human Safety

  • The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.

    Journal of Applied Toxicology 2022 Feb;42(2):318-333.
    2021/12/1
    Masaharu Fujita1), Yusuke Yamamoto1), Sayaka Wanibuchi1), Shinichi Watanabe2), Hiroaki Yamaga2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kazuya Takeuchi5), Kohei Kamiya5), Tsuyoshi Kawakami6), Kohichi Kojima7), Takashi Sozu8), Hajime Kojima9), Toshihiko Kasahara1), Atsushi Ono10)
    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University
  • Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances:Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system

    The Japanese Society for Alternatives to Animal Experiments
    2021/11/11-11/13
    Hiroaki Yamaga (Joint research with Fujifilm)
  • Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing

    The Japanese Society for Alternatives to Animal Experiments
    2021/11/11-11/13
    Junko Ueno
  • The Japanese Society for Alternatives to Animal Experiments Best Presentation Award
    A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The Japanese Society for Alternatives to Animal Experiments 
    2021/11/11-11/13
    Joint research with Kao Corporation and Sunstar Corporation
  • The Japanese Society of Toxicology Excellent Research Presentation Award
    Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation

    The Japanese Society of Toxicology
    2021/7/7-7/9
    Seiya Aizawa (Joint research with Kao Corporation and Sunstar Corporation)
  • Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances

    Journal of Applied Toxicology
    2021/2/26
    Hiroaki Yamaga1),Shinichi Watanabe1), Masaharu Fujita2), Yusuke Yamamoto2), Toshihiko Kasahara2),Shinsuke Kataoka1)
    1) Safety Science Research Laboratories, Lion Corporation, 2) Safety Evaluation Center, Fujifilm Corporation

Analysis Technology

  • Analysis of Bactericidal Effects of Solvents -Effects in Surfactant Composition Systems-.

    The society for Antibacterial and Antifungal Agents, Japan
    2021/9/8-9/9
    Keisuke Nakajima
  • The Role of MS in the Development of Daily Use Products -Study of Odor Component Analysis-

    BMS conference
    2021/7/12-7/14
    Takuya Tsutui
  • Contribution to the work of expanding communication of products for dentists using atomic force microscopy (AFM)

    The Japan Society for Analytical Chemistry
    2021/5/22-5/23
    Ryota Hashimoto

Life Sciences Technology

  • Factor analysis of changes in vitality of workers during the COVID-19 pandemic

    Japanese Society for Chronobiology
    2021/11/20-11/21
    Takahiko Suiko
  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    Japanese Society for Chronobiology
    2021/11/20-11/21
    Ayumi Sawada
  • Sleep Quality and Productivity Decline under a New Coronavirus Infection Epidemic

    The Japanese Society of Sleep Research
    2021/9/23-9/24
    Yuki Nagamori
  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    The Japanese Society of Sleep Research
    2021/9/23-9/24
    Ayumi Sawada
  • Let’s do what we want to do with good sleep habits! —What I've learned from sleep research

    11th CSJ Chemistry Festa
    2021/9/22-9/24
    Takao Iwai
  • Functionality of Sake Yeast —Improvement of Sleep Quality

    23th Joint Yeast Symposium
    2021/9/2-9/3
    Tomomi Sano
  • Association between frequency of tooth brushing and health-related factors among workers

    Annual Meeting of the Japanese Society of Time-based Nutrition
    2021/8/27-8/28
    Takao Iwai
  • Development of an original in vitro exercise model and its application to the analysis of the mechanism of action of β-hydroxy-β-methylbutyrate (HMB)

    Japan Society of Exercise and Sports Physiology
    2021/8/20-8/21
    Satoko Satoh
  • Irregular meal timing is associated to the mental health in Japanese workers.

    Nutrients
    2021/8/13
    Yu Tahara1), Saneyuki Makino1), Takahiko Suiko2), Yuki Nagamori2), Takao Iwai2), Megumi Aono2), and Shi-genobu Shibata1)
    1) Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, 2) Research and Development Headquarters, Lion Corporation
  • Improving sleep and productivity with solutions tailored to each person’s sleep state

    Online seminar to introduce health management solutions([Organizer] Fair Work Co.)
    2021/6/29
    Takuya Ichinose
  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    The Pharmaceutical Society of Japan
    2021/3/26-3/29
    Takumi Mitome

Living and Fabric Care

  • Preventing odor when drying clothes indoors

    2021 AOCS Annual Meeting & Expo
    2021/5/3-5/14
    Masanori Fushitani

Medicated Care

  • Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction

    The Ocular Surface
    2021/10/16
    Tomo Suzuki1),2), Koji Kitazawa1), Yuko Cho1),2), Masataka Yoshida3), Takashi Okumura3), Atsushi Sato3), Shigeru Kinoshita4)
    1) Department of Ophthalmology, Kyoto Prefectural University of Medicine, 2) Department of Ophthalmology, Kyoto City Hospital Organization, 3) Research and Development Headquarters, Lion Corporation, 4) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine
  • Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate

    Japan Pharmaceutical Association
    2021/9/19-9/20
    Yasushi Kudo
  • Usefulness of acetaminophen in ibuprofen-induced small bowel injury

    Journal of Japanese Society of Gastroenterology
    2021/9/10
    Miyu Kitahara, Yuki Sakamoto, Kimura Ryuto, Keiko Seki
  • Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil

    Translational Vision Science & Technology April 2021, Vol.10, 21.
    2021/4/20
    Keisuke Watanabe1), Masataka Yoshida1), Takashi Okumura1), Takayuki Sassa2), Akio Kihara2), Akira Uchiyama1)
    1) Research and Development Headquarters, Lion Corporation, 2) Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences
  • Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

    The Japanese Society of gastroenterology
    2021/4/15-4/17
    Keiko Seki
  • Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora

    The Japanese Society of gastroenterology
    2021/4/15-4/17
    Yuto Aita

Body Care

  • Well-being as a Key Factor for the Creation of Sustainable Local Towns, People, and Workplaces: An Introduction to Well-being Management Initiatives in Ehime, a Region that Sees a Ray of Light in Solving Local Problems

    Wellbeing Expo & Conference 2021 Autumn
    2021/11/4-11/5
    Takuya Ichinose
  • Approaches to Visualizing the Effectiveness of Care Focusing on Virus Contact Transmission in the Home

    Symposium on Cleaning
    2021/10/12-10/15
    Keiko Otake
  • Development of materials and functional foods for dry mouth, eyes, and skin (dry syndrome)

    Food Development Expo 2021 (Hi Japan/ FiT Japan/ S-tec Japan/ LL Japan)
    2021/10/6-10/8
    Takao Iwai
  • Proper hand washing, gargling, and disinfection methods and their effects

    Division of Colloid Surface Chemistry
    2021/9/15-9/21
    Yuriko Omoto
  • Development of skin care detergents with excellent moisturizing and tactile properties

    Development and Latest Technology of Moisturizing Cosmetics for Prevention of Rough Skin and Hands
    2021/5/28
    Michihiro Suzuki
  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN2021
    2021/5/12-5/14
    Tsubasa Yamaguchi
  • Washing Cosmetics

    Basic Cosmetic Technology Seminar
    2021/2/15-2/19
    Risako Toki

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