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研究実績:2019年

口腔に関する技術

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports 2019 Nov. 9, Article number: 16124
    2019/11/6
    Ryutaro Jo1), Yuichiro Nishimoto2), Kouta Umezawa3), KazumaYama1), YutoAita1), Yuko Ichiba1), Shinnosuke Murakami2),4), Yasushi Kakizawa1), Takashi Kumagai3), TakujiYamada2),5),6) Shinji Fukuda2),4),6),7),8)
    1) Research and Development Headquarters, 2) Metabologenomics, Inc.,3) Hiyoshi Oral Health Clinics. ,4) Institute for Advanced Biosciences, Keio University, 5) Department of Life Science and Technology, Tokyo Institute of Technology, 6) PRESTO, Japan Science and Technology Agency, 7) Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8) Transborder Medical Research Center, University of Tsukuba
  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics
    2019/10/15-10/19
    森下 聡
  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research volume 26, Article number: 246 (2019)
    2019/9/12
    Ryosuke Hachisuka1),2), Toshiaki Kobayashi3), Masayuki Yamaguchi2)
    1) School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters, Lion Corporation, 3) The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)
  • A New Method to Speculate Halitosis Level Using Machine Learning

    国際歯科研究学会議(IADR)
    2019/6/19-6/22
    道林 千晶
  • Lactoferrinはヒト歯肉線維芽細胞において細胞増殖と創傷治癒を促進する―in vitro研究

    日本歯周病学会会誌 2019 年 61 巻 1 号 p. 18-27
    2019/03/29
    鈴木 苗穂
  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports 2019 9, Article number:3559
    2019/3/5
    Takuya Hayakawa1), Shizuka Kawasaki1), Yutaka Hirayama1),TakuyaTsutsui1), Eiji Sugiyama2), KiyoAdachi1), Ryo Kon1), Makoto Suematsu2), Yuki Sugiura2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Biochemistry, Keio University School of Medicine

界面に関する技術

  • アニオン界面活性剤水溶液の加水分解に与えるミセルの効果と、ミセル界面に吸着したプロトンの測定

    コロイドおよび界面化学討論会 第70回記念国際会議 OKINAWA COLLOIDS 2019
    2019/11/3-11/4
    三宅 深雪
  • 長鎖脂肪酸メチルエステルを活用したMEEの開発

    日本油化学会第58回年会
    2019/9/24-9/26
    常光 研徳
  • ビタミンナノエマルションの角膜細胞浸透性を利用した新点眼薬の開発

    第71回日本生物工学会大会
    2019/9/16-9/18
    三宅 深雪
  • パーム油のC18留分を活用した衣料用洗剤用の新規MEEの開発

    CESIO 11th world surfactant congress (2019)
    2019/6/3-6/5
    辻村 将
  • Homogenized Bimetallic Catalysts from Metal-Organic Framework Alloys

    Chemistry of Material. 2019, 31, 11, 4205–4212
    2019/3/22
    Jet-Sing M. Lee1), Yu-ichi Fujiwara2), Susumu Kitagawa1), Satoshi Horike1),3),4),5)
    1) Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, 2) Research & Development Headquarters, LION Corporation, 3) AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory (ChEM-OIL), Kyoto University, 4) Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 5) Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology

安全性に関する技術

  • Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice

    Journal of Chromatography B Volume 1137
    2019/11/25
    KanakoYuyama1), YoshitakaNakamura1), RihoTateyama1), RiekoArakaki2), TakuyaTsutsui1), NaozumiIshimaru2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences
  • The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

    Journal of Applied Toxicology Volume39, Issue11 November 2019 Pages 1492-1505
    2019/7/17
    Masaharu Fujita1), Yusuke Yamamoto1), Shinichi Watanabe2), Tsunetsugu Sugawara2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kei Kusakari5), Yoshihiko Kurokawa5), Tsuyoshi Kawakami6), Kohichi Kojima7), Takashi Sozu8), Takuto Nakayama8),Takeru Kusao8), Jon Richmond9), Kleinstreuer Nicole10), Bae-Hwa Kim11), Hajime Kojima12), Toshihiko Kasahara1), Atsushi Ono13)
    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc, 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Dr. Jon Richmond: Advice and Consultancy,10) NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, 11)College of Natural Sciences Keimyung University,12) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 13) Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University
  • ヒト3次元培養口腔粘膜モデルを用いる口腔粘膜刺激性試験代替法の開発-オーラルケア用途原料・製品における口腔粘膜刺激性評価フローの設定に関する検討-

    日本動物実験代替法学会 第32回大会
    2019/6/26-6/28
    相澤 聖也
  • 難水溶性感作性物質に対する有機溶媒系で評価可能なADRA-OSの開発

    日本動物実験代替法学会 第32回大会
    2019/6/26-6/28
    山鹿 宏彰

生命科学に関する技術

  • 睡眠の質測定とケア行動の提案が健康増進と労働生産性の向上に及ぼす影響

    第15回日本疲労学会
    2019/5/18-5/19
    永盛 友樹

住まいと衣類のケア

  • Design of nanoscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    Chemical Engineering Science volume 203 (2019) page 113–121.
    2019/3/27
    Motoyuki Iijima1),2), Masahiro Hayakawa2), Junichi Tatami1),2), Koichiro Nakamura3), Shinichi Nagashima3)
    1) Faculty of Environment and Information Sciences, Yokohama National University, 2) Graduate School of Environment and Information Sciences, Yokohama National University, 3) Research and Development Headquarters, Lion Corporation
  • 室内環境における微生物汚染実態および制御
    浴室のカビ汚染実態および制御

    日本防菌防黴学会誌,Vol.47,No.6,pp.233−237(2019)
    山岸 弘

メディカルケア

  • Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

    PLoS One. 2019 Nov 6;14(11):
    2019/11/6
    Tetsuhiro Shimodaira1), Shigeo Mikoshiba1), Toru Taguchi2),3)
    1) Lion Corporation, 2) Department of Physical Therapy, Niigata University of Health and Welfare, 3) Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare
  • ラット炎症性疼痛モデルにおける痛みの程度・服用タイミングによるアスピリンの鎮痛効果の検討

    YAKUGAKU ZASSHI 140, 91 97 (2020)
    2019/10/25
    北原 美優, 関 桂子, 翠川 辰行, 有田 淳哉, 内山 章
    ライオン株式会社 研究開発本部

カラダのケア

  • Rooibos extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulate the M3 muscarinic acetylcholine receptor

    The 7th International Conference on Food Factors
    2019/12/1-12/5
    岩井 崇郎
  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    Eur J Pharm Biopharm. 2020 Jan;146:10-18
    2019/11/16
    Takumi Mitsudome1), Mitsutoshi Moribe1),Yoshiyuki Obayashi1), Akira Uchiyama1), Megumi Aono1)
    1) Research & Development Headquarters, Lion Corporation
  • ルイボスエキスのムスカリンM3受容体活性化作用とヒト乾燥緩和機能

    第29回日本口腔内科学会 合同学術大会
    2019/9/20-9/23
    岩井 崇郎
  • ルイボスエキスの乾燥緩和機能に関するin vivo作用機序検討

    第29回日本口腔内科学会 合同学術大会
    2019/9/20-9/23
    岩井 崇郎
  • ルイボスエキス含有食品による口、目、肌のヒト乾燥緩和機能

    第28回日本シェーグレン症候群学会学術大会
    2019/9/13-9/14
    岩井 崇郎
  • Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice

    Journal of Oral Biosciences Volume 61, Issue 3, September 2019, Pages 179-182
    2019/8/7
    Rieko Arakaki1), Aya Ushio1), Satoru Kisoda1), Mami Sato1), Yoshitaka Nakamura2), Kanako Yuyama2), Riho Tateyama2), Satoru Morishita2), Noriyuki Monoi2), Yasusei Kudo1), Naozumi Ishimaru3)
    1) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences, 2) Research & Development Headquarters, Lion Corporation, 3) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences
  • 機能性表示食品制度におけるスポーツ・運動分野の表示表現の拡大に向けた検証

    第19回日本抗加齢医学会総会
    2019/6/14-6/16
    野村 充
  • Rooibos (Aspalathus linearis) extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulates exocrine glands via the M 3 muscarinic acetylcholine receptor

    Journal of Functional Foods Volume 55, April 2019, Pages 248-254
    2019/2/7
    Saori Nishimachi1),Takao Iwai1), Yoshitaka Nakamura1), Kanako Yuyama-Masuda1), Takuya Tsutsui1),Noriyuki Monoi1), Akira Uchiyama1),2), Seiji Nakamura3)
    1) Research & Development Headquarters, Lion Corporation, 2) Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, 3) Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
  • A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration

    BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2019, VOL. 83, NO. 10, 1851–1857
    2019/1/4
    Satoko Sato1), Mitsuru Nomura1), Ikko Yamana1), Akira Uchiyama1), Yasuro Furuichi2), Yasuko Manabe2), Nobuharu L Fujii2)
    1) Research and Development Headquarters, Lion Corporation, 2) Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University

製品プロセスに関する技術

  • コンプレックスによる界面活性剤含有排水の処理検討

    第22回日本水環境学会シンポジウム
    2019/9/5-9/6
    清水 喜雄

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