Close
Close
Lion takes its responsibility for providing customers with peace of mind through safety evaluations based on scientific evidence extremely seriously. We conduct wide-ranging safety assessments of the effects of Lion products and their raw materials on people and the environment, applying technologies related to living organisms, including those in the fields of molecular biology and physiology. These assessments ensure that customers can use Lion products with confidence. In addition to performing evaluations, Lion is involved in the development of safety assessment technologies, such as alternatives to animal testing.
The importance of safety evaluation and confirmation is the same worldwide. Lion takes a global perspective as it aggressively gathers and analyzes safety data from in and outside Japan and uses such data in actual safety evaluations. At the same time, Lion actively participates in various industry associations, cooperating to help solve problems.
Alternative Approaches to Animal Testing
Evaluating Biodegradability and Environmental Impact—Fulfilling Our Social Responsibility to the Environment
Cytokine Release Behavior in EpiSensA of Skin Sensitizing Substances and False Positive Substances
The 37th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2024/11/30
Junko Motoyama
Using expert knowledge to re-evaluate the sensitisation potential of quaternary ammonium salts
The 58th CONGRESS OF THE EUROPEAN SOCIETIES OF TOXICOLOGY
2024/11/17
Satosi Kojima (Joint presentation with Lhasa Limited)
Development of Comprehensive Databases and Automation Processes for Safety Assessment
The 38th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2025/11/02
Kasumi Kusakari
Development of oral mucosal irritation test method using human 3D cultured oral mucosal model
Lecture on the Oil and Fat Technology Award for Excellence in Papers
2024/09/05
Seiya Aizawa （Joint presentation with Kao Corporation and Sunstar Corporation）
Development of oral mucosal irritation test method using human 3D cultured oral mucosal model
Technical Lectures at the Japanese Society for Alternatives to Animal Experiments
2024/08/28
Seiya Aizawa （Joint presentation with Kao Corporation and Sunstar Corporation）
Case Study on the DASS Evaluation of Fatty Acid Methyl Ester Group Using Alternative Skin Sensitization Test Methods
The 51st Annual Meeting of the Japanese Society of Toxicology
2024/07/04
Junko Motoyama
Efforts in safety assessment of difficult-to-test substances in household products
Organization for Research and Communication on Environmental Risk of Chemicals information magazine, "Chemicals and Environment", No.185 (2024.5) ,p7-9
2024/04/30
Yuhei Kijima
Analysis of Exposure Concentration of the Linear Alkylbenzen Sulfonate (LAS) in Domestic Rivers
58th Annual Conference of Japan Society on Water Environment
2024/03/06
Yuuya Fujita
Development of oral mucosal irritation test using a human 3D cultured oral mucosal model
The 25th (2023) Oils and Fats Technical Paper Excellence Award
2024/02/21
Seiya Aizawa (Joint award with Kao Corporation and Sunstar Corporation)
Application of Defined Approaches for Skin Sensitization and sensitization threshold in skin sensitization risk assessment of mixture raw materials: A case study using plant extracts
The 36th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments Poster Award Excellent Presentation Award
2023/11/29
Shinichi Watanabe
Application of Defined Approaches for Skin Sensitization and Sensitization Thresholds in Skin Sensitization Risk Assessment of Mixture Ingredients: A Case Study Using Plant Extracts
The 36th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments Poster Award Excellent Presentation Award
2023/11/27
Shinichi Watanabe
Development of an alternative oral mucosal irritation test： a proposal to the approval procedure of quasi-drugs
The 36th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments Poster Award Excellent Presentation Award
2023/11/27
Seiya Aizawa
The inter-laboratory validation study of EpiSensA for predicting skin sensitization potential
Journal of Applied Toxicology Oct 2023
2023/10/28
Shin-Ichi Watanabe
Evaluation of Skin Sensitization Using Amino Acid Derivative Reactivity Assay-Organic Solvent (ADRA-OS), an Alternative to Animal Tests: Effects of Epoxy Compound
Journal of Clinical Toxicology, Vol.13 Iss.4 No:1000541
2023/09/15
Hiroaki Yamaga
Development of an oral mucosal irritation test using a three-dimensional human buccal oral mucosal model
Toxicology in Vitro Volume 87, March 2023, 105519
2023/03/01
Seiya Aizawa
Ring study of ADRA, in chemco alternative test method for skin sensitization, aimed at revised guideline
The 35th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2022/11/18-11/20
Hiroaki Yamaga,Shinichi Watanabe
Verification of Amino acid Derivative Reactivity Assay-Organic Solvent (ADRA-OS): Evaluation of Epoxides and Surfactants
ICT 2022 – XVIth International Congress of Toxicology
2022/9/18-9/21
Ryo Koizumi
Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human Buccal Oral Mucosal Model -Analysis of Mechanisms of Toxicity in Mucosal Cells-
The 49th Annual Meeting of the Japanese Society of Toxicology
2022/6/30-7/2
Seiya Aizawa
Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.
Journal of Applied Toxicology volume42, Issue 6 1078-1090 Jun 2022
2022/1/18
Yusuke Yamamoto 1), Masaharu Fujita 1) , , Shinichi Watanabe 2),Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)
1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation,
3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,
The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.
Journal of Applied Toxicology volume42, Issue 2 318-333 Feb 2022
2021/12/1
Masaharu Fujita 1), Yusuke Yamamoto 1), Sayaka Wanibuchi 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)
1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,
Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances：Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Hiroaki Yamaga （Joint research with Fujifilm）
Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Junko Ueno
The Japanese Society for Alternatives to Animal Experiments Best Presentation Award
A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Joint research with Kao Corporation and Sunstar Corporation
A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model
The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
2021/11/11-11/13
Joint research with Kao Corporation and Sunstar Corporation
The Japanese Society of Toxicology Excellent Research Presentation Award
Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation
The 48th Annual Meeting of the Japanese Society of Toxicology
2021/7/7-7/9
Seiya Aizawa（Joint research with Kao Corporation and Sunstar Corporation）
Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances
Journal of Applied Toxicology volume41, Issue 10 1634-1648 Oct 2021
2021/2/26
Hiroaki Yamaga 1),Shinichi Watanabe 1),Masaharu Fujita 2),Yusuke Yamamoto 2),Toshihiko Kasahara 2),Shinsuke Kataoka 1)
1)Safety Science Research Laboratories, Lion Corporation
2)Safety Evaluation Center, Fujifilm Corporation