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Research Accomplishments

Oral Technology

  • Age-related deterioration of the human dentin

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Chika Akabane

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro

    European Federation of Periodontology 10th

    2022/6/15-6/18

    Kota Tsutsumi

  • Development of EIS type biosensor to detect cortisol in saliva

    The 69th Japan Society of Applied Physics Spring Meeting

    2022/3/22-3/26

    Yuki Maruyama

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports 2022 12, Article number:689

    2022/1/13

    Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)

    1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health

    2021/12/21-12/23

    Yukari Sekine

  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health

    2021/12/15

    Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto1, Yasushi Koike1 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)

    1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,

  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The Japanese Society of Conservative Dentistry

    2021/10/28-11/10

    Masakazu Ono

  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    Japanese Society of Pediatric Dentistry

    2021/10/17-10/23

    Ryosuke Hachisuka

  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64st Autumn Meeting of the Japanese Society of Periodontology

    2021/10/15-10/16

    Yu Yamamoto

  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Yama Kazuma

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Riho Makino

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Mari Yutori

  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Taku Iwamoto

  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yukihide Aoyama

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yasushi Koike

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Kota Tsutumi

  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE

    2021/9/17

    Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1) , Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)

    1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function 3)Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University

  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    Engineering Research Express, Vol.3 (2021) 015006

    2021/5/11

    Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,

  • Survey on oral care habits and halitosis among general community residents

    Annual Meeting of the Japanese Society for Oral Health Care

    2021/4/17-4/18

    Chiyoko Uchiyama

  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The Chemical Society of Japan

    2021/3/19-3/21

    Mari Yutori

  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The Chemical Society of Japan

    2021/3/19-3/21

    Riho Makino

  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)

    2021/3/11

    Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports volume 11:861 (2021)

    2020/1/13

    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki Research and Development Headquarters, Lion Corporation,

  • Basic study on staining and removal of dentin by various beverages

    Japanese Society for Oral Health

    Ayaka Iwasaki

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology

    2020/12/1

    Reona Noda,Shizuka Kawasaki,Ryosuke Hachisuka

  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    Japanese Society for Oral Health

    2020/10/20-10/22

    Koichiro Hayashi

  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    Japan Academy of Esthetic Dentistry

    202010/3-10/4

    Ryota Hashimoto

  • Development of "RePERO", an application to support breath care

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    2020/9/13-9/16

    Kengo Oka

  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration

    2020/9/13

    Kenichiro Shibasaki

  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science

    2020/7/21-7/24

    Yuya Kimoto

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The Japanese Society of Conservative Dentistry

    2020/6/11-6/12

    Rika Oda

  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    the 63rd Spring Meeting of the Japanese Society of Periodontology

    2020/5/29-5/30

    Kenji Egashira

  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    Japanese Society of Pediatric Dentistry

    2020/5/20-5/21

    Mai Satake

  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research(IADR) 2020

    2020/3/18-3/21

    Tsuguno Yamagushi

  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University

    2020/3/11

    Eiji Nishinaga

  • Fluoride and Caries Prevention

    THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY

    2020/1/7

    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

  • Japan Institute of invention and innovation No.:6591988(Toothbrushes that can limit damage to the user's mouth)

    Ryosuke Haschisuka

  • Asian Pacific Society of Periodontology Meeting 2019 Poster presentation competition Lab research 1st Prize 「Effects of pyrrolidone carboxylic acid on dentin collagen degradation and demineralization」

    Shiori Ishii

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports 2019 Nov. 9, Article number: 16124

    2019/11/6

    Ryutaro Jo 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), KazumaYama 1), YutoAita 1), Yuko Ichiba 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1), Takashi Kumagai 3), TakujiYamada 2),5),6) Shinji Fukuda2),4),6),7),8)

    1)Research and Development Headquarters, 2)Metabologenomics, Inc.,3)Hiyoshi Oral Health Clinics. ,4)Institute for Advanced Biosciences, Keio University,5)Department of Life Science and Technology, Tokyo Institute of Technology, 6)PRESTO, Japan Science and Technology Agency,8)Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8)Transborder Medical Research Center, University of Tsukuba,

  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics

    2019/10/15-10/19

    Satoshi Morishita

  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research 2019 volume 26, Article number: 246

    2019/9/12

    Ryosuke Hachisuka 1)2), Toshiaki Kobayashi 3), Masayuki Yamaguchi 2)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology,2)Research & Development Headquarters, Lion Corporation, 3)The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)

  • A New Method to Speculate Halitosis Level Using Machine Learning

    International Association for Dental Research (IADR)

    2019/6/19-6/22

    Chiaki Michibayashi

  • Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts―in vitro study

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/03/29

    Naho Suzuki

  • The Journal of Japanese Society of Periodontology, 2019 Journal Award 「Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study」

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports 2019 9, Article number:3559

    2021/12/21-12/23

    Yukari Sekine

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health

    2019/3/5

    Takuya Hayakawa 1), Shizuka Kawasaki 1), Yutaka Hirayama 1),TakuyaTsutsui 1), Eiji Sugiyama 2), KiyoAdachi 1), Ryo Kon 1), Makoto Suematsu 2), Yuki Sugiura 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biochemistry, Keio University School of Medicine,

  • Importance of approaches to the host's defense mechanism in the prevention of periodontal disease and the effects of vitamin E

    The 149th Meeting of The Japanese Society of Conservative Dentistry

    2018/11/1

    Mari Yutori

  • Evaluation of vitamin-E permeability using human three-dimensional culture epidermis model

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Kazuaki Kojima

  • The wound healing effect of vitamin-E on human gingival fibroblasts

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Mari Yutori

  • Effects of copper gluconate on oral malodor

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Masato Takahashi

  • Technologies supporting oral care products

    Japanese Association for Oral Biology

    2018/9/5-9/7

    Mari Yutori

  • Effects of sodium polyacrylate on periodontal disease biofilm in vitro

    The Japanese Society of Periodontology

    2018/6/1-6/2

    Yusuke Kawanobe

  • THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR Excellent scientific papers First Class 「Decomposition and removal of dental model plaque by using toothpaste containing dextranase」

    THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR

    2018/4/12

    Yuko Aoki 1), Gotaro Izumi 1), Yasuo Nomura 1), Kenichiro Shibasaki 1), 刘婧 2)、李德豹 2)、安丰宝 2) ,郑苏江 3)

    1)Lion Corporation 2)獅王日用化工(青島)有限公司 3)中国科学院理化技術研究所

Interface Technology

  • Analysis of oral microbiome formation process in infancy

    Japanese Society for Bacteriology

    2018/3/27-3/29

    Ryutaro Jo

  • Structural Analysis of Nanoparticles and Gel Networks Formed by Chlorohydroxyaluminum by Small- and Wide-Angle X-ray Scattering

    Division of Colloid Surface Chemistry

    2021/9/15-9/17

    Sachiko Takano

  • Enhancement of Virus Inactivation of Cationic Surfactants by Sulfate Ions

    Japan Oil Chemicals' Society

    2021/9/6-9/11

    Rei Saito

  • Dispersion stabilization of fragrance capsules in fabric softeners - Viscoelasticity control in vesicle systems based on depletion aggregation

    Japan Oil Chemicals' Society

    2021/9/6-9/11

    Asami Miyajima

  • Synergistic effects of surfactants and chelating agents on tightly adherent keratin for simple cleaning

    Japan Oil Chemicals' Society

    2021/9/6-9/11

    Shinya Sudo

  • Permeation Behavior of Liposoluble Substances Solubilized in Bile Salts/Phospholipid Mixture Micelles through Biological Membrane Models

    Japan Oil Chemicals' Society

    2021/9/6-9/11

    Sara Isurugi

  • Foundation, Oil and Fat Industury Kaikan, 64th Excellent article award in Oil and Fat technology  「Effect of Mineral Oil Addition on Membrane Stability of Polar Lipids Derived from Mibum」

    Masataka Yoshida,Atushi Sato

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubule

    Japan Oil Chemicals' Society

    2020/11/2-11/7

    Miyuki Miyake

  • Purpose of establishment and activities of the "Social Health Strategy Research Institute" aiming to improve social health and realize a sustainable symbiotic society

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    2020/9/14-9/16

    Miyuki Miyake

  • Purpose of establishment and activities of the "Social Health Strategy Research Institute" aiming to improve social health and realize a sustainable symbiotic society

    Rigaku Jounal

    2020/5/1

    Yukari Sekine

  • 第51回油脂産業論文 佳作 (Japanese only) 「製薬産業界との新結合による油脂産業界の新価値創出と健康格差の解消」

    Yasushi Kudo

  • Micellar Effects on the Hydrolysis Reaction of an Anionic Surfactant in Aqueous Solution and Measurements of Adsorbed Proton on the Micellar Surface.

    The 70th Divisional Meeting of Divison of Colloid and Surface Chemistory 2019

    2019/11/3-11/4

    Miyuki Miyake

  • Developing New Methyl Ester Ethoxylate with Long Alkyl Chain Length

    The 58th Annual Meeting of the Japan Oil Chemists' Society

    2019/9/24-9/26

    Akinori Joko

  • Development of novel eye drops by applying the permeability of vitamin nanoemulsions into corneal cell

    The 71st Society for Biotechnology, Japan/Annual Meeting

    2019/9/16-9/18

    Miyuki Miyake

  • Developing New Methyl Ester Ethoxylate Derived from C18 Fraction of Palm Oil for Liquid Laundry Detergent

    CESIO 11th world surfactant congress (2019)

    2019/6/3-6/5

    Sho Tsujimura

  • Foundation, Oil and Fat Industury Kaikan, 63th Excellent article award in Oil and Fat technology 「Structural Viscosity Induced by Depletion Effect in Stable Vesicle Dispersion」

    J. Oleo Sci. 68, (9) 837-845 (2019)

    2019.5.25

    Asami Miyajima , Ryo Inoue, Erika Onishi, Miyuki Miyake, and Ryo Hyodo Research & Development Headquarters, LION Corporation,

  • Homogenized Bimetallic Catalysts from Metal-Organic Framework Alloys

    Chemistry of Material. 2019, 31, 11, 4205–4212

    2019/3/22

    Jet-Sing M. Lee 1), Yu-ichi Fujiwara 2), Susumu Kitagawa 1), Satoshi Horike 1),3),4),5)

    1)Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, 2) Research & Development Headquarters, LION Corporation, 3)AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory (ChEM-OIL), Kyoto University, 4)Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 5) Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology,

  • The 7th Young Researcher Encouragement Award 「Application of environmentally friendly surfactant MES to liquid detergents」

    Japan Oil Chemists' Society Kanto Branch

    Atsunori Morigaki

  • Foundation, Oil and Fat Industury Kaikan, 63th Excellent article award in Oil and Fat technology 「Structural Viscosity Induced by Depletion Effect in Stable Vesicle Dispersion」

    Asami Miyagima, Ryo Inoue, Miyuki Miyake

  • Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling

    Applied Microbiology and Biotechnology

    2018/8/10

    Yuki Maruyama 1), Yoshihiro Toya 2), Hiroshi Kurokawa 1), Yuka Fukano 1), Atsushi Sato 1), Hiroyasu Umemura 1), Kaoru Yamada 1), Hideaki Iwasaki 1), Norio Tobori 1), Hiroshi Shimizu 2)

    1)Research and Development Headquarters, Lion Corporation, 2)Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University

  • Construction of Evaluation Model of Tear Film Lipid Layer Stability, and Research of Influence of Endogenous Ingredients in Meibum on the Stability

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    Masataka Yoshida

  • Japan Oil Chemist's Society, 52th Progress Award 「Structural Analysis in solutions - Innovation for surfactant science using scattering techniques -」

    Japan Oil Chemist's Society, 52th

Aroma Technology

  • Analysis of Brain Activity Related to Fragrance Preference of Fabric Softener for Clothes

    The Japanese Association for the Study of Taste and Smell

    2021/10/19-10/21

    Kai Saito

  • Extraction and Analysis Method of Fragrance in High Concentration Surfactant

    Symposium on the Chemistry of Terpenes, Essential oils and Aromatics

    2020/10/24-10/26

    Keita Sawada

  • JAPAN RESEARCH INSTITUTE OF MATERIAL TECHNOLOGY, Gold Poster Award 「Analysis of solubilization of perfume molecules in micelles using small-angle X-ray scattering(SAXS)」

    JAPAN RESEARCH INSTITUTE OF MATERIAL TECHNOLOGY,

    2018/12/1

    Kai Saitoh 1)、Masaaki Akamatsu 1)、Kenichi Sakai 1)、2)、Hideki Sakai 1)、2)、小倉卓 2)、3)

    Tokyo University of Science 1)、 Reserch Institute for Science & Technology 2)、Lion Corporation3)

Environment and Human Safety

  • Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.

    Journal of Applied Toxicology 18 January 2022

    2022/1/18

    Yusuke Yamamoto 1), Masaharu Fujita 1) , , Shinichi Watanabe 2),Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)

    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation,
    3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,

  • The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.

    Journal of Applied Toxicology 2022 Feb;42(2):318-333.

    2021/12/1

    Masaharu Fujita 1), Yusuke Yamamoto 1), Sayaka Wanibuchi 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)

    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,

  • Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances:Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system

    The Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Hiroaki Yamaga (Joint research with Fujifilm)

  • Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing

    The Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Junko Ueno

  • The Japanese Society for Alternatives to Animal Experiments  Best Presentation Award A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society for Alternatives to Animal Experiments  Best Presentation Award 「A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model」

    The Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society of Toxicology Excellent Research Presentation Award Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation

    The Japanese Society of Toxicology

    2021/7/7-7/9

    Seiya Aizawa(Joint research with Kao Corporation and Sunstar Corporation)

  • Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances

    Journal of Applied Toxicology

    2021/2/26

    Hiroaki Yamaga 1),Shinichi Watanabe 1),Masaharu Fujita 2),Yusuke Yamamoto 2),Toshihiko Kasahara 2),Shinsuke Kataoka 1)

    1)Safety Science Research Laboratories, Lion Corporation 2)Safety Evaluation Center, Fujifilm Corporation

  • Introduction of EpiSensA, an alternative method for skin sensitization test using 3D human epidermis model, for evaluation of poorly water-soluble substances

    The Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Junko Ueno

  • The Japanese Society for Alternatives to Animal Experiments  President's Special Award A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society for Alternatives to Animal Experiments Validation study of the Epidermal Sensitization Assay (EpiSensA), an alternative method for skin sensitization testing (Phase I of institutional reproducibility)

    The Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Joint research with Kao Corporation, KOSE Corporation and Food and Drugs Safety Center

  • Case studies of microbial problems in the manufacturing genba of cosmetics and personal care products

    Fragrance journal : Research & development for cosmetics, toiletries & allied industries  48(5), 53-64, 2020-05

    2020/5/1

    Masahiko Otani

  • New approach to evaluation and classification of irritation intensity of oral care ingredients using a three-dimensional human buccal mucosal model.

    Society of Toxicology Annual Meeting

    2020/3/15-19

    Joint research with Kao Corporation and Sunstar Corporation

  • Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

    Jounal of Applied Toxicology, 2020;40:843-854

    2020/2/12

    Miyuki Akimoto 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Kousuke Yoshida 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), | Kei Kusakari 5), Kohei Kamiya 5), Kohichi Kojima 6), Tsuyoshi Kawakami 7), Hajime Kojima 8), Atsushi Ono 9), Toshihiko Kasahara 1), Masaharu Fujita 1)

    1)Fujifilm Corporation, Safety Evaluation Center, 2)Lion Corporation, 3)Mitsui Chemicals, Inc. Chemical Safety Department, 4)Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory, 5)Nissan Chemical Corporation, Biological Research Laboratories, 6)Food and Drug Safety Center, Hatano Research Institute, 7)Division of Environmental Chemistry, National Institute of Health Sciences, 8)Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 9)Okayama University

  • Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice

    Journal of Chromatography B Volume 1137,

    2019/11/25

    KanakoYuyama 1), YoshitakaNakamura a), RihoTateyama a), RiekoArakaki b), TakuyaTsutsui a), NaozumiIshimaru b),

    a)Research & Development Headquarters, Lion Corporation, b)Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences,

  • The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

    Journal of Applied Toxicology Volume39, Issue11 November 2019 Pages 1492-1505

    2019/7/17

    Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Takuto Nakayama 8),Takeru Kusao 8), Jon Richmond 9), Kleinstreuer Nicole 10), Bae-Hwa Kim 11), Hajime Kojima 12), Toshihiko Kasahara 1), Atsushi Ono 13)

    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc, 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Dr. Jon Richmond: Advice and Consultancy,10) NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, 11)College of Natural Sciences Keimyung University,12) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 13) Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University,

  • Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human Buccal Mucosal Model - Study on Setting of Oral Mucosal Irritation Evaluation Flow for Raw Materials and Products for Oral Care -

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2019/6/26-6/28

    Seiya Aizawa

  • Development of ADRA-OS(Organic solvent reaction System)for poorly water-soluble sensitizers

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2019/6/26-6/28

    Hiroaki Yamaga

  • The Study of Utility of a Three-dimensional Human Buccal Mucosal Model for Oral Mucosal Irritation Prediction of Raw Materials for Oral Care Supplies by the Three Facilities

    The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2018/11/23-11/25

    Seiya Aizawa

  • Current state and Issues of utilization of animal experiment alternative methods in safety evaluation by chemical industry

    The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2018/11/23-11/25

    Shinichi Watanabe

  • Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay

    Journal of Applied Toxicology 2019 Feb;39(2):191-208

    2018/9/16

    Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Hajime Kojima 8), Atsushi Ono 9), Yasuhiro Katsuoka 1), Hideto Tanabe 10), Hiroshi Yokoyama 10), Toshihiko Kasahara 1)

    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Mitsui Chemicals, Inc., Chemical Safety Department 4) Sumitomo Chemical Co., Ltd., Environmental Health Science Laboratory, 5) Nissan Chemical Corporation, Biological Research Laboratories, 6) National Institute of Health Sciences, Division of Environmental Chemistry,7) Food and Drug Safety Center, Hatano Research Institute, 8) National Institute of Health Sciences, Biological Safety Research Center, Division of Risk Assessment, 9) Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Division of Pharmaceutical Sciences,10) Fujifilm Corporation, Research & Development Management Headquarters, Analysis Technology Center

Analysis Technology

  • A Study of Utility of a Three-dimensional Human Buccal Mucosal Model and Gingival Model for Oral Mucosal Irritation Evaluation

    The Japanese Society of Toxicology

    2018/7/18-7/20

    Seiya Aizawa

  • The society for Antibacterial and Antifungal Agents, Japan, Poster Award  Analysis of Bactericidal Effects of Solvents -Effects in Surfactant Composition Systems-

    The society for Antibacterial and Antifungal Agents, Japan

    2021/9/8-9/9

    Keisuke Nakajima

  • The Role of MS in the Development of Daily Use Products -Study of Odor Component Analysis-

    BMS conference

    2021/7/12-7/14

    Takuya Tsutui

  • Contribution to the work of expanding communication of products for dentists using atomic force microscopy (AFM)

    The Japan Society for Analytical Chemistry

    2021/5/22-5/23

    Ryota Hashimoto

  • Basic knowledge of microorganisms and introduction of antibacterial and antiviral measures

    ATTS

    2020/10/16

    Seiichi Tobe

Life Sciences Technology

  • Contribution to the development work of functional foods using LC-MS technology

    The Japan Society for Analytical Chemistry

    2020/5/23-5/24

    Atushi Satoh

  • Factor analysis of changes in vitality of workers during the COVID-19 pandemic

    Japanese Society for Chronobiology

    2021/11/20-11/21

    Takahiko Suiko

  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    Japanese Society for Chronobiology

    2021/11/20-11/21

    Ayumi Sawada

  • Sleep Quality and Productivity Decline under a New Coronavirus Infection Epidemic

    The Japanese Society of Sleep Research

    Yuki Nagamori

    著者発表者

  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    The Japanese Society of Sleep Research

    2021/9/23-9/24

    Ayumi Sawada

  • Let's do what we want to do with good sleep habits! ~What I've learned from sleep research

    11th CSJ Chemistry Festa

    2021/9/22-9/24

    Takao Iwai

  • Functionality of Sake Yeast -Improvement of Sleep Quality

    23th Joint Yeast Symposium

    2021/9/2-9/3

    Tomomi Sano

  • Association between frequency of tooth brushing and health-related factors among workers

    Annual Meeting of the Japanese Society of Time-based Nutrition

    2021/8/27-8/28

    Takao Iwai

  • Development of an original in vitro exercise model and its application to the analysis of the mechanism of action of β-hydroxy-β-methylbutyrate (HMB)

    Japan Society of Exercise and Sports Physiology

    2021/8/20-8/21

    Satoko Satoh

  • Irregular meal timing is associated to the mental health in Japanese workers.

    Nutrients

    2021/8/13

    Yu Tahara 1), Saneyuki Makino 1), Takahiko Suiko 2), Yuki Nagamori 2), Takao Iwai 2), Megumi Aono 2), and Shi-genobu Shibata 1),

    1 Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda Univer-sity 2 Research and Development Headquarters, Lion Corporation

  • Improving sleep and productivity with solutions tailored to each person's sleep state

    Online seminar to introduce health management solutions([Organizer] Fair Work Co.)

    2021/6/29

    Takuya Ichinose

  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    The Pharmaceutical Society of Japan

    2021/3/26-3/29

    Takumi Mitome

  • BtoBtoC business that aims to improve health and work productivity through better sleep.

    Kenkojumyo Report

    2021/3/4

    Aono Megumi

  • Influence of remote working on sleep during COVID-19 pandemic

    Japanese Society for Chronobiology

    2020/9/26~9/27

    Takahiko Suiko

  • Improving Worker Productivity and Workplace Safety by Measuring Sleep Quality and Suggesting Sleep Improvement Methods

    Japan Society for Occupational Mental health

    2020/7/4-7/5

    Takuya Ichinose

  • Creating a New Value of Sleep Health Care; A Healthy Body Provided by Good Sleep

    Japanese Cosmetic Science Society

    2020/6/12-6/13

    Tomomi Sano

  • Effects of muscle contraction on metabolomic profiling using in vitro exercise model

    the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2020/3/25-3/28

    Satoko Satoh

  • Effects of lutein and astaxanthin intake on the improvement of cognitive functions among healthy adults: a systematic review of randomized controlled trials

    Nutrients

    2020/2/27

    Rui Nouchi 1),2), Takahiko Suiko 3), Eriko Kimura 3), Hiroki Takenaka 3), Michiaki Murakoshi 3), Akira Uchiyama 3), Megumi Aono 3), Ryuta Kawashima 2) ,4)

    1 Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC),Tohoku University, 2 Smart Aging Research Center (S.A.R.C.), Tohoku University, 3 Research and Development Headquarters, Lion Corporation, 4 Department of Functional Brain Imaging, In

  • Social Implementation Relay "Efficacy of Sleep Check & Care and Efforts at Hirosaki COI

    HealthyAging Innovation Summit

    2020/1/31

    Aono Megumi

  • Purpose of establishment and activities of the "Social Health Strategy Research Institute" aiming to improve social health and realize a sustainable symbiotic society

    Healthcare IT 2020

    2020/1/28-1/29

    Aono Megumi

  • The effects of sleep quality measurement and sleep care solution on health promotion and work productivity improvement.

    The 15th Japanese Society of Fatigue Science

    2019/5/18-5/19

    Yuki Nagamori

  • Japanese sake yeast supplementation reduces daytime fatigue via sleep quality improvement: a double-blind randomized placebo-controlled clinical trial

    International Society of Food Function

    2018/10/27-10/28

    Yuki Nagamori

  • Effects of Japanese sake yeast supplementation on human skin quality and analysis of its mechanism

    24th European Sleep Research Societ

    2018/9/25-9/28

    Kengo Oka

  • Japanese Society for food factors (2018) Skin Improvement by Sleep Supplement “Sake Yeast”

    Japanese Society for food factors

    2018/9/7-9/8

    Yuki Nagamori

  • Mechanism analysis of Japanese sake yeast induced non-rapid eye movement sleep.

    Japan Oil Chemicals' Society

    2018/9/4-9/6

    Yoshitaka Nakamura

  • Japanese sake yeast improves daytime fatigue

    The Japanese Society of Sleep Research

    2018/7/11-7/13

    Kaori Hirao

  • Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis

    the 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/15-3/19

    Yuki Nagamori

  • The sleep enhancement supplement Japanese sake yeast improves skin quality in humans—A randomized, double-blind placebo-controlled clinical trial—

    Japanese Pharmacology Therapeitics

    2018

    2018

    Yuki Nagamori(LION)

Living and Fabric Care

  • Preventing odor when drying clothes indoors

    2021 AOCS Annual Meeting & Expo

    2021/5/3-5/14

    Masanori Fushitani

  • Efforts to increase awareness of laundry methods using QR codes

    Symposium on Cleaning

    2020/10/5-10/7

    Yuki Saito

  • Introduction to Commodities and Services by Means of Up-to-date Technological Studies by Companies Development of "Anti-Smelling Top Super NANOX"

    The Japan Research Association for Textile End-Uses

    2020/6/20-6/21

    Keisuke Mori

  • Efforts with apparel manufacturers to raise awareness of washing methods

    The Japan Reseach Association for textile end-uses

    2020/6/20-6/21

    Yuki Saito

  • Visualization of skin texture - Performance evaluation of detergents for clothing by X-ray CT

    Rigaku Hounal

    2020/10/21

    Yukari Sekine

  • Design of nanoscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    Chemical Engineering Science volume 203 (2019) page 113–121.

    2019/3/27

    Motoyuki Iijima a),b) Masahiro Hayakawa b), Junichi Tatami a),b), Koichiro Nakamura c), Shinichi Nagashima c)

    a)Faculty of Environment and Information Sciences, Yokohama National University, b) Graduate School of Environment and Information Sciences, Yokohama National University,c)Research and Development Headquarters, Lion Corporation,

  • Current Status and Control of Microbiological Contamination in Indoor Environment Mold Pollution and Control in the Bathroom

    JOURNAL OF ANTIBACTERIAL AND ANTIFUNGAL AGENTS, JAPAN,Vol.47,No.6,pp.233−237(2019)

    Hiroshi Yamagishi

  • Talk about “TOP”

    The Japan Research Association for Textile End-Uses

    2018/11/20-11/26

    Ishizuka Tomotaka

  • Basic lecture "Preservateve efficacy test method"

    45th Annual Meeting, The society for Antibacterial and Antifungal Agents, Japan

    2018/11/14

    Masahiko Otani

  • Evaluation of the Effect of the Characteristic of the Dish Washing Detergent has influence on the Psychophysiological State and Behavior

    The 20th Japan Society of Kansei Engineering

    2018/9/4-9/6

    Masaki Miyajima

  • Analysis of a burden reduction effect during the laundry using liquid detergent with new value

    The 20th Japan Society of Kansei Engineering

    2018/9/4-9/6

    Shota Okeda

  • Study on the washing method of urine-smelling clothing

    Annual Meeting of The Japan Research Association for Textile End-Uses

    2018/6/23-6/24

    Haruka Takahashi

  • Development of Top HYGIA

    Journal of the Japan Reseach Association for textile end-uses

    2018/6/28

    Nanami Sasaki

  • Effects of various microwave cookers on the microwave cooking

    The Japan Society of Home Economics

    2018/5/25-5/27

    Shuhei Kameyama

  • Study on bacteria flora to prevent fabric odors

    2018 AOCS Annual Meeting and & Expo

    2018/5/6-5/9

    Keisuke Mori

  • Relationship of bacteria and odor on washing and solution for suppressing the odor

    Sentaku no kagaku

    2018/05/01

    Keisuke Mori

  • Study on evaluation techniques (self-evaluation and biometorics response) for touch feeling given with fabric softner

    Product development and evaluation techniques that appeal to the sensibility of the human

    2018

    Emiko Hashimoto

  • Case Study of Fragrance Evaluation for Fabric Softener

    TECHNICAL INFORMATION INSTITUTE CO.LTD

    2018

    Shiori Nakamura

Medicated Care

  • About the touch feeling and its textile properties obtained with new laundry detergent

    The society of Fiber Science and Technology, Japan

    Aiko Tai

  • Elucidation of the relationship between suppression of NSAIDs-induced small intestinal injury by acetaminophen and bacterial flora

    The 49th Japan Society of Ulcer Research

    2022/2/11-2/13

    Yuto Aita

  • Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction

    The Ocular Surface

    2021/10/16

    Tomo Suzuki a),b),Koji Kitazawa a), Yuko Cho a),b), Masataka Yoshida c), Takashi Okumura c), Atsushi Sato c), Shigeru Kinoshita d)

    a) Department of Ophthalmology, Kyoto Prefectural University of Medicine b) Department of Ophthalmology, Kyoto City Hospital Organization c) Research and Development Headquarters, Lion Corporation, d) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine

  • Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate

    Japan Pharmaceutical Association

    2021/9/19-9/20

    Yasushi Kudo

  • Usefulness of acetaminophen in ibuprofen-induced small bowel injury

    Journal of Japanese Society of Gastroenterology

    2021/9/10

    Miyu Kitahara, Yuki Sakamoto, Kimura Ryuto, Keiko Seki

  • Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil

    Translational Vision Science & Technology April 2021, Vol.10, 21.

    2021/4/20

    Keisuke Watanabe 1), Masataka Yoshida 1), Takashi Okumura 1), Takayuki Sassa 2), Akio Kihara 2), Akira Uchiyama 1)

    1) Research and Development Headquarters, Lion Corporation, 2)Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences

  • Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

    The Japanese Society of gastroenterology

    2021/4/15-4/17

    Keiko Seki

  • Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora

    The Japanese Society of gastroenterology

    2021/4/15-4/17

    Yuto Aita

  • Comparison of the drug efficacy of OTC antipyretic analgesic ingredients using a mouse model of tension-type headache

    Japanese Association for Study of Pain

    2020/11/7-11/8

    Yuki Ogawa

  • Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells

    Journal of Ocular Pharmacology and TherapeuticsVol. 36, No. 9

    2020/11/5

    Kyohei Kabashima 1), Akira Murakami 2), Nobuyuki Ebihara 3)

    1) Lion Corporation Odawara Research Center, 2)Department of Ophthalmology, Juntendo University Graduate School of Medicine,3)Department of Ophthalmology, Juntendo University Urayasu Hospital,

  • Creation of a rat model of functional dyspepsia with chronic downregulation of tight junction component proteins

    the Japanese Society of Ulcer Research

    2020/7/20

    Mayumi Tsuri、Takuya Hayakawa

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

    Heliyon, Volume 6, Issue 5, May 2020,

    2020/5/24

    Mizuho Niibori 1),Yasushi Kudo 1),Takuya Hayakawa 1), Keiko Ikoma-Seki Ryosuke Kawamata 1), Atsushi Sato 1), Kazue Mizumura 2),3)

    1)Research & Development Headquarters, Lion Corporation, 2) Department of Physiology, Nihon University School of Dentistry, 3) College of Life and Health Sciences, Chubu University,

  • The Effect of Nonpolar Lipids in Meibum on Stability of Tear Film Lipid Layer against Compression-Expansion Cycles

    Journal of Oleo Science. 2020

    2020/2/4

    Masataka Yoshida 1), Masato Yamaguchi 2) Atsushi Sato 1) , Miyuki Miyake 1) , Nobuhito Tabuchi 1) , Ryo Kon 1) , and Ken-ichi Iimura 3)

    1) Research and Development Headquarters, Lion Corporation, 2)Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 3) Division of Engineering and Agriculture, Graduate School of Regional Development and Creativity, Utsunomiya University,

  • Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

    PLoS One. 2019 Nov 6;14(11):

    2019/11/6

    Tetsuhiro Shimodaira 1, Shigeo Mikoshiba 1, Toru Taguchi 2 3

    1)Lion Corporation, 2)Department of Physical Therapy, Niigata University of Health and Welfare, 3)Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare,

  • The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing

    YAKUGAKU ZASSHI 140, 91・97 (2020)

    2019/10/25

    Miu Kitahara,Keiko Seki, Tatsuyuki Midorikawa, Junya Arita, and Akira Uchiyama Research & Development Headquarters, Lion Corporation,

  • A thin layer of sucrose octasulfate protects esophageal mucosal epithelium against reflux esophagitis

    AAPS PharmSci360

    2018/11/4-11/7

    Takuya Hayakawa

  • Acetylsalicylic acid and conventional NSAIDs ameliorate muscular mechanical hyperalgesia through mechanisms other than COX-2 inhibition

    IASP (International Association for the Study of Pain)

    2018/9/12-9/16

    Tetsuhiro Shimodaira

  • Acetylsalicylic acid and loxoprofen ameliorate secondary hyperalgesia through mechanisms other than COX-2 inhibition in a rat model of osteoarthritis

    IASP (International Association for the Study of Pain)

    2018/9/12-9/16

    Kudo Yasushi

  • Influence of Non-Polar Lipids and Polar Lipids on Tear Film Lipid Layer Stability

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    2018/9/18-9/20

    Masataka Yoshida

  • Vitamin A and Ery Eye

    Food and Medicine

    2018/09/01

    Nobuhito Tabuchi

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in a rat osteoarthritis model —Effects of aspirin on ASIC3 expression and glial cells—

    The 40th Annual Meeting Of Japanese Association for Study of Pain

    2018/6/15-6/16

    Mizuho Nibori

  • Relationship between Meibum Composition and Eye Fatigue in Meibomian Gland Dysfunction Patients

    Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Changes in Meibum Composition with Aging and Meibomian Gland Dysfunction

    Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Structural Analysis of Tear Film Lipid Layer in Compression-Expansion Cycles

    The Chemical Society of Japan

    2018/3/20-3/23

    Masataka Yoshida

  • Influence of Saturated Non-Polar Lipids on Tear Film Lipid Layer Stability

    The Chemical Society of Japan

    2018/3/20-3/23

    Masataka Yoshida

  • Hot Topics Award at Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory 「Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis」

    Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory

    2018/3/16

    ○Satoko Sato 1)、Yusuke Takamura 1)、Ikkou Yamana 1)、Mitsuru Nomura 1)、Akira Uchiyama 1)、Yasuro Furuichi 2)Yasuko Manabe 2)、Nobuharu Fujii 2)

    1)Research & Development Headquarters, LION Corporation, 2)Graduate School of Human Health Sciences, Tokyo Metropolitan University

  • Comparison of effects of antacids on NSAIDs-induced gastric damages

    The 46th Meeting of the Japanese Society of Ulcer Research

    2018

    Kudo Yasushi

Body Care

  • Foundation, Oil and Fat Industury Kaikan, 62th Excellent article award in Oil and Fat technology 「Membrane Permeation of Giant Unilamellar Vesicles and Corneal Epithelial Cells with Lipophilic Vitamin Nanoemulsions」

    Miyuki Miyake 1), Masatoshi Kurioka 1), Masahiro Takagi 2)

    1)Lion Corporation,2)Japan Advanced Institute of Science and Technology

  • Hair evaluation method based on the actual situation of consumers

    The 58th SOCIETY OF COSMETIC CHEMISTS OF JAPAN

    2022/2/8

    Izumi Oishi

  • Well-being as a Key Factor for the Creation of Sustainable Local Towns, People, and Workplaces: An Introduction to Well-being Management Initiatives in Ehime, a Region that Sees a Ray of Light in Solving Local Problems

    Wellbeing Expo & Conference ​2021 Autumn

    2021/11/4-11/5

    Takuya Ichinose

  • Approaches to Visualizing the Effectiveness of Care Focusing on Virus Contact Transmission in the Home

    Symposium on Cleaning

    2021/10/12-10/15

  • Development of materials and functional foods for dry mouth, eyes, and skin (dry syndrome)

    Food Development Expo 2021 (Hi Japan/ FiT Japan/ S-tec Japan/ LL Japan)

    2021/10/6-10/8

    Takao Iwai

  • Proper hand washing, gargling, and disinfection methods and their effects

    Division of Colloid Surface Chemistry

    2021/9/15-9/21

    Yuriko Omoto

  • Development of skin care detergents with excellent moisturizing and tactile properties

    Development and Latest Technology of Moisturizing Cosmetics for Prevention of Rough Skin and Hands

    2021/5/28

    Michihiro Suzuki

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN2021

    2021/5/12-5/14

    Tsubasa Yamaguchi

  • Washing Cosmetics

    Basic Cosmetic Technology Seminar

    2021/2/15-2/19

    Risako Toki

  • Foot trouble due to sweat and odor and development of corresponding products

    FRAGRANCE JOURNAL 2020 No.477(Vol.48/No.3)

    2021/3/15

    Shinichi Nagashima

  • Technology Introduction of "Nice Slim Essence Lactoferrin" to be delivered to the intestines ~~Visceral Fat Reduction Mechanism and Enteric Coating Technology~

    Japanese Association for lactferrin

    2020/12/6

    Takumi Mitsudome

  • Ideas for preventing infections in the home and workplace, hand washing and cleaning

    Japan Oil Chemicals' Society

    2020/11/2-11/7

    Yukari Sekine

  • Application of Anionic Polymers in Cosmetics

    COSMETIC STAGE Vol.15, No.1 2020

    2020/10/1

    Tomoki Sano

  • Intraoral Approach to Improve the Nasolabial Fold

    Cosmetic stage 14(6), 39-45, 2020-08

    2020/8/1

    Yujiro Endo

  • Washing the skin.

    Japanese Dermatological Association

    2020/6/4-6/7

    Hotaka Asano

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2020

    2020/4/20-4/22

    Takumi Mitsudome

  • Effect of lactoferrin intestinal solvent on visceral fat reduction

    Functional Food

    2020

    Michiaki Murakoshi、Kanae Nakamura、Tomoji Ono

  • Enteric-coated lactoferrin decreases abdominal visceral fat in humans: a randomized, double-blind, placebo-controlled, parallel-group study

    Jpn Pharmacol Ther 2020 : 48 : 1179-85

    2020

    Satoko Sato 1), Mitsuru Nomura 1), Akira Uchiyama 1), Ikuo Fukuhara 2)

    1)Research & Development Headquarters, Lion Corporation, 2) Fukuhara Clinic, Eniwa,

  • Effects of Coexistent Components on the Antiperspirant Action of Aluminium Chlorohydrate

    J. Soc. Cosmet. Chem. Jpn. 55(1): 45─51

    2020

    Tomoki Sano, Wataru Shirae, Yuriko Omoto, Shinichi Nagashima, Atsunori Morigaki, Yasushi Kakizawa, Takaki Ikenishi Research & Development Headquarters, Lion Corporation,

  • A Study on a Longitudinal Evaluation Method Using Facial Expression Analysis to Capture Emotional Changes during Cosmetics Use

    The Japanese Society for Cognitive Psychology

    Eisuke Inagaki

  • Rooibos extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulate the M3 muscarinic acetylcholine receptor

    The 7th International Conference on Food Factors

    2019/12/1-12/5

    Takao Iwai

  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    Eur J Pharm Biopharm . 2020 Jan;146:10-18

    2019/11/16

    Takumi Mitsudome 1), Mitsutoshi Moribe 1),Yoshiyuki Obayashi 1), Akira Uchiyama 1),, Megumi Aono 1),

    1) Research & Development Headquarters, Lion Corporation,

  • Rooibos extract activates M3 muscarinic acetylcholine receptor and relieves human dryness

    The 29th Annual Meeting of the Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • In vivo mechanism study on the dryness relief function of rooibos extract

    The 29th Annual Meeting of the Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • Effects of Rooibos (Aspalathus linearis) Extract on Dryness of Mouth, Eye and Skin in Human

    The 28th Annual Meeting of the Japanese Society for Sjögren's syndrome

    2019/9/13-9/14

    Takao Iwai

  • Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice

    Journal of Oral Biosciences Volume 61, Issue 3, September 2019, Pages 179-182

    2019/8/7

    Rieko Arakaki 1), Aya Ushio 1), Satoru Kisoda 1), Mami Sato 1), Yoshitaka Nakamura 2), Kanako Yuyama 2), Riho Tateyama 2), Satoru Morishita 2), Noriyuki Monoi 2), Yasusei Kudo 1), Naozumi Ishimaru 3)

    1)Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences, 2)Research & Development Headquarters, Lion Corporation, 3) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences,

  • Exercise and sports health claims in the system of Foods with Function Claims

    The 19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    2019/6/14-6/16

    Mitsuru Nomura

  • Rooibos (Aspalathus linearis) extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulates exocrine glands via the M 3 muscarinic acetylcholine receptor

    Journal of Functional Foods Volume 55, April 2019, Pages 248-254

    2019/2/7

    Saori Nishimachi a),Takao Iwai a), Yoshitaka Nakamura a), Kanako Yuyama-Masuda a), Takuya Tsutsui a),Noriyuki Monoi a), Akira Uchiyama a),b), Seiji Nakamura c),

    a)Research & Development Headquarters, Lion Corporation, b)Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, c)Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University,

  • A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration

    BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2019, VOL. 83, NO. 10, 1851–1857

    2019/01/04

    Satoko Sato 1), Mitsuru Nomura 1), Ikko Yamana 1), Akira Uchiyama 1), Yasuro Furuichi 2), Yasuko Manabe 2), Nobuharu L Fujii 2),

    1),Research and Development Headquarters, Lion Corporation, 2),Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University ,

  • Relationship between female hormone and hair: Development of hair loss treatment

    Japan Hair Science Association

    2018/12/01

    Shunsuke Hiroshima

  • Quantitative Evaluation of Hair Growth in the Treatment of Hormone Replacement Therapy

    The Japan Society for Menopause and Women's Health

    2018/11/3-11/4

    Yujiro Endo

  • Effect of lactoferrin on energy expenditure enhancement in reprogrammed functional brown adipocytes

    25th International Conference of FFC

    2018/10/27-10/28

    Kanae Nakamura

  • Gene expression order attributed to genome reduction and the steady cellular state in Escherichia coli

    Front Microbiol. 2018; 9: 2255.

    2018/9/20

    Bei-Wen Ying 1),2), Kazuma Yama 3)

    1)Institute of Biology and Information Science, East China Normal University 2)Faculty of Life and Environmental Sciences, University of Tsukuba 3)Research & Development Headquarters, Lion Corporation

  • Gene expression order attributed to genome reduction and the steady cellular state in Escherichia coli

    Front Microbiol. 2018; 9: 2255.

    2018/9/20

    Bei-Wen Ying1),2), Kazuma Yama 3)

    1)Institute of Biology and Information Science, East China Normal University 2)Faculty of Life and Environmental Sciences, University of Tsukuba 3)Research & Development Headquarters, Lion Corporation

  • Design of multiscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    SCEJ The Society of Chemical Engineers, Japan

    2018/9/18-9/20

    Koichiro Nakamura

  • Effects of lactoferrin on lipid metabolism in white adipocytes and brown adipocytes

    FOOD STYLE21

    2018/08/01

    Kanae Nakamura

  • Beta-hydroxy-beta-methylbutyrate (HMB) augments muscle contraction-induced protein synthesis via mTORC1 signaling in cultured L6 myotubes

    the european sleep research society

    2018/4/21-4/25

    Satoko Satoh

  • Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis

    the 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/15-3/19

    Satoko Satoh

  • Relationship between female hormone and hair: Development of hair loss treatment

    Japan Hair Science Association

    2018/03/01

    Yujiro Endo

  • The sleep enhancement supplement Japanese sake yeast improves skin quality in humans—A randomized, double-blind placebo-controlled clinical trial—

    Japanese Pharmacology Therapeitics Volume 46, Issue 11, 1851 - 1857 (2018)

    2018

    Yuki Nagamori, et al.

  • Anti-Obesity Effect of Lactoferrin; Subgroup Analysis Excluding Subjects with Obese and/or Hyper-LDL Cholesterolemia

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

    2018

    Tomoji Ono 1), Michiaki Murakoshi 1), Akira Uchiyama 1)

    1)Research & Development Headquarters, Lion Corporation

  • The effects of carotenoids intake for improvement of cognitive functions in healthy adults: a systematic review and meta-analysis of randomized controlled trials

    PROSPERO

    2018

    Takahiko Suiko

Container and Packaging Development

  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes

    BioMetals

    2018

    Kanae Nakamura

  • Lion's Approach to Container Development and Environmental Considerations

    The Japanese Society of Printing Science and Technology  Gravure Research Group 13th Mini-Symposium

    2021/11/10

    Yasuhiro Makimura

  • Japan Packaging Institute,Best Presentation Award  「Pre-detergent for laundry Development of new shower caps」

    Japan Packaging Institute

    2021/12/2

    Syunsuke Kawanishi

  • Development of the MIGACOT toothpaste set for office use

    Japan Packaging Institute

    2021/12/2

    Hironobu Hara

  • Toward Horizontal Recycling of Toiletry Pouches

    JSDA Engineering Containers and Waste Technical Committee

    2021/11/16

    Masahiro Honma

  • Examples of Corporate 3R+Renewable Initiatives

    Ichihara City Environmental Council

    2021/12/22

    Isamu Oishi

  • JAPAN PACKAGING CONTEST 2020 Package Design Award 「MIGACOT」

  • JAPAN PACKAGING CONTEST 2019 [Technical Packaging Award] ;Japan Packaging Institute Look Plus Bathtub Cleansing

  • JAPAN PACKAGING CONTEST 2019 [Toiletry Packaging Award] ;Japan Packaging Institute Kireikirei Medicated Hand Gel

Product Process Technology

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports

    2022/1/13

    Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)

    1)Research and Development Headquarters, Lion Corporation
    2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)
    Transborder Medical Research Center, University of Tsukuba,

  • Applying Methyl Ester Sulfonate(MES) to Liquid Detergent:Improving the Physical Properties of MES for the Manufacturing Process

    AOCS

    2021/5/28

    Kazuki Shimizu

  • Chemical Engineering Promoting Circular Economy Initiatives for the Recycled Use of Manufacturing Process Wastewater

    SCEJ 52nd Autumn Meeting

    2021/9/23

    Naoki Nishikawa

  • Recent trend in water reuse technology "Recycling of Wastewater from the Manufacturing Process of Toiletry Products"

    The 22nd JSWE Symposium

    2019/9/5-9/6

    Yoshio Shimizu

  • New Methyl Ester Ethoxylate Derived from C18 Fraction of Palm Oil for Liquid Laundry Detergen

    2018 AOCS Annual Meeting & Expo

    2018/5/6-5/9

    Akinori Joko

Others

  • Environmental Solution Technology,17,3 (2018) Recent trend in water reuse technology "Recycling of Wastewater from the Manufacturing Process of Toiletry Products"

    Environmental Solution Technology

    Naoki Nishikawa

  • 株式会社ハー・ストーリィ主催 女性のあした大賞(健康経営コース)(Japanese Only)
     「女性の健康課題解決のための企業ネットワーク・共通アンケートの構築によるリテラシー向上施策」

    株式会社ハー・ストーリィ主催 女性のあした大賞

    2021/12/8

    Yujiro Endo

  • Health management and work style reform that is resilient to social change

    Social Health Strategy Research Institute

    2020/7/27-7/31

    Aono Megumi

  • The 42nd Freshers' Industrial Essay Contest ⅠParts prize of excellence 「Creating real value for companies based on the latest team medicine」

    Haruka Morita

  • THE NIKKAN KOGYO SHIMBUN, LTD., The 43st Freshers Industrial Essay Contest, Part Ⅰ, 2nd place award 「Breaking away from the same orderly manner, learning from telework」

    Saki Uemura

  • THE NIKKAN KOGYO SHIMBUN, LTD., The 42st Freshers Industrial Essay Contest, Part Ⅰ Award of excellence 「Create real value in company: taking a hint from a model of the latest team based approach in medical 」

    2018/11/8

    Keita Sawada

  • Non-profit Incorporated Association, The Society of Chemical Engineers, Japan,

    The Society of Chemical Engineers, Japan(2018)

  • 第32回 粉体工業功績者表彰(Japanese Only)

  • 2018年度(第50回)油脂産業論文 佳作(Japanese only)
    「油脂産業と薬学的技術の融合による油脂ヘルスケアコンソーシアム構築 ~100歳まで生き生きと働ける社会の実現へ向けて~」

    Miyuki Maruyama

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