Close

Medicated Care

As self-medication grows more common, consumers’ health-related needs are diversifying. In response, Lion is constantly working to develop highly functional products that leverage its proprietary technologies. This approach enables Lion to create products that have a unique market position. For example, Lion has used its proprietary technologies related to quickly dissolving active ingredients in the development of BUFFERIN analgesics and cold medicine. Lion’s technologies for the stable formulation of vitamin A have been used in Smile eye drops. Applying polymer technology, Lion created Halix topical analgesic and anti-inflammatory products, which are both gentle on the skin and highly adhesive. And Stoppa antidiarrheal products employ Lion’s oral medicine fast-disintegration technology, for relief whenever needed with just one tablet that can be taken without water. Going forward, Lion will continue to actively develop products based on its unique proprietary technologies.

R&D Case Study

Research Accomplishment—Medicated Care

  • About the touch feeling and its textile properties obtained with new laundry detergent

    The society of Fiber Science and Technology, Japan

    Aiko Tai

  • Elucidation of the relationship between suppression of NSAIDs-induced small intestinal injury by acetaminophen and bacterial flora

    The 49th Japan Society of Ulcer Research

    2022/2/11-2/13

    Yuto Aita

  • Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction

    The Ocular Surface

    2021/10/16

    Tomo Suzuki a),b),Koji Kitazawa a), Yuko Cho a),b), Masataka Yoshida c), Takashi Okumura c), Atsushi Sato c), Shigeru Kinoshita d)

    a) Department of Ophthalmology, Kyoto Prefectural University of Medicine b) Department of Ophthalmology, Kyoto City Hospital Organization c) Research and Development Headquarters, Lion Corporation, d) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine

  • Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate

    Japan Pharmaceutical Association

    2021/9/19-9/20

    Yasushi Kudo

  • Usefulness of acetaminophen in ibuprofen-induced small bowel injury

    Journal of Japanese Society of Gastroenterology

    2021/9/10

    Miyu Kitahara, Yuki Sakamoto, Kimura Ryuto, Keiko Seki

  • Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil

    Translational Vision Science & Technology April 2021, Vol.10, 21.

    2021/4/20

    Keisuke Watanabe 1), Masataka Yoshida 1), Takashi Okumura 1), Takayuki Sassa 2), Akio Kihara 2), Akira Uchiyama 1)

    1) Research and Development Headquarters, Lion Corporation, 2)Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences

  • Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

    The Japanese Society of gastroenterology

    2021/4/15-4/17

    Keiko Seki

  • Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora

    The Japanese Society of gastroenterology

    2021/4/15-4/17

    Yuto Aita

  • Comparison of the drug efficacy of OTC antipyretic analgesic ingredients using a mouse model of tension-type headache

    Japanese Association for Study of Pain

    2020/11/7-11/8

    Yuki Ogawa

  • Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells

    Journal of Ocular Pharmacology and TherapeuticsVol. 36, No. 9

    2020/11/5

    Kyohei Kabashima 1), Akira Murakami 2), Nobuyuki Ebihara 3)

    1) Lion Corporation Odawara Research Center, 2)Department of Ophthalmology, Juntendo University Graduate School of Medicine,3)Department of Ophthalmology, Juntendo University Urayasu Hospital,

  • Creation of a rat model of functional dyspepsia with chronic downregulation of tight junction component proteins

    the Japanese Society of Ulcer Research

    2020/7/20

    Mayumi Tsuri、Takuya Hayakawa

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

    Heliyon, Volume 6, Issue 5, May 2020,

    2020/5/24

    Mizuho Niibori 1),Yasushi Kudo 1),Takuya Hayakawa 1), Keiko Ikoma-Seki Ryosuke Kawamata 1), Atsushi Sato 1), Kazue Mizumura 2),3)

    1)Research & Development Headquarters, Lion Corporation, 2) Department of Physiology, Nihon University School of Dentistry, 3) College of Life and Health Sciences, Chubu University,

  • The Effect of Nonpolar Lipids in Meibum on Stability of Tear Film Lipid Layer against Compression-Expansion Cycles

    Journal of Oleo Science. 2020

    2020/2/4

    Masataka Yoshida 1), Masato Yamaguchi 2) Atsushi Sato 1) , Miyuki Miyake 1) , Nobuhito Tabuchi 1) , Ryo Kon 1) , and Ken-ichi Iimura 3)

    1) Research and Development Headquarters, Lion Corporation, 2)Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 3) Division of Engineering and Agriculture, Graduate School of Regional Development and Creativity, Utsunomiya University,

  • Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

    PLoS One. 2019 Nov 6;14(11):

    2019/11/6

    Tetsuhiro Shimodaira 1, Shigeo Mikoshiba 1, Toru Taguchi 2 3

    1)Lion Corporation, 2)Department of Physical Therapy, Niigata University of Health and Welfare, 3)Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare,

  • The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing

    YAKUGAKU ZASSHI 140, 91・97 (2020)

    2019/10/25

    Miu Kitahara,Keiko Seki, Tatsuyuki Midorikawa, Junya Arita, and Akira Uchiyama Research & Development Headquarters, Lion Corporation,

  • A thin layer of sucrose octasulfate protects esophageal mucosal epithelium against reflux esophagitis

    AAPS PharmSci360

    2018/11/4-11/7

    Takuya Hayakawa

  • Acetylsalicylic acid and conventional NSAIDs ameliorate muscular mechanical hyperalgesia through mechanisms other than COX-2 inhibition

    IASP (International Association for the Study of Pain)

    2018/9/12-9/16

    Tetsuhiro Shimodaira

  • Acetylsalicylic acid and loxoprofen ameliorate secondary hyperalgesia through mechanisms other than COX-2 inhibition in a rat model of osteoarthritis

    IASP (International Association for the Study of Pain)

    2018/9/12-9/16

    Kudo Yasushi

  • Influence of Non-Polar Lipids and Polar Lipids on Tear Film Lipid Layer Stability

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    2018/9/18-9/20

    Masataka Yoshida

  • Vitamin A and Ery Eye

    Food and Medicine

    2018/09/01

    Nobuhito Tabuchi

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in a rat osteoarthritis model —Effects of aspirin on ASIC3 expression and glial cells—

    The 40th Annual Meeting Of Japanese Association for Study of Pain

    2018/6/15-6/16

    Mizuho Nibori

  • Relationship between Meibum Composition and Eye Fatigue in Meibomian Gland Dysfunction Patients

    Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Changes in Meibum Composition with Aging and Meibomian Gland Dysfunction

    Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Structural Analysis of Tear Film Lipid Layer in Compression-Expansion Cycles

    The Chemical Society of Japan

    2018/3/20-3/23

    Masataka Yoshida

  • Influence of Saturated Non-Polar Lipids on Tear Film Lipid Layer Stability

    The Chemical Society of Japan

    2018/3/20-3/23

    Masataka Yoshida

  • Hot Topics Award at Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory 「Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis」

    Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory

    2018/3/16

    ○Satoko Sato 1)、Yusuke Takamura 1)、Ikkou Yamana 1)、Mitsuru Nomura 1)、Akira Uchiyama 1)、Yasuro Furuichi 2)Yasuko Manabe 2)、Nobuharu Fujii 2)

    1)Research & Development Headquarters, LION Corporation, 2)Graduate School of Human Health Sciences, Tokyo Metropolitan University

  • Comparison of effects of antacids on NSAIDs-induced gastric damages

    The 46th Meeting of the Japanese Society of Ulcer Research

    2018

    Kudo Yasushi

Share