Dental and Oral Care | Product Development Research | Research & Development | Lion Corporation

In recent years, with the diversification of lifestyles and values as well as the aging of the population and increase in average life expectancy, oral care has become increasingly important part of maintaining quality of life. Against this backdrop, Lion will continue to create new value that goes beyond existing frameworks by bringing together the fundamental technologies and R&D capabilities it has cultivated over 120 years as Japan’s No. 1 oral care manufacturer. We are developing products and services that lead to better oral and overall health, as well as improved quality of life.

R&D Case Study

Research Accomplishment—Dental and Oral Care

Age-related deterioration of the human dentin

International Association for Dental Research(IADR)

2022/6/20-6/25

Chika Akabane
Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro

European Federation of Periodontology 10th

2022/6/15-6/18

Kota　Tsutsumi
Development of EIS type biosensor to detect cortisol in saliva

The 69th Japan Society of Applied Physics Spring Meeting

2022/3/22-3/26

Yuki Maruyama
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

Scientific Reports 2022 12, Article number:689

2022/1/13

Yuki Maruyama ¹), Yuichiro Nishimoto ²), Kouta Umezawa ³), Ryosuke Kawamata ¹),Yuko Ichiba ¹), KotaTsutsumi ¹), Mitsuo Kimura ¹), Shinnosuke Murakami ²),⁴), Yasushi Kakizawa ¹),Takashi Kumagai ³), TakujiYamada ²),⁵) & Shinji Fukuda ²),⁴),⁶),⁷)

1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,
Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

Annual Meeting of Japanese Society of Public Health

2021/12/21-12/23

Yukari Sekine
A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

BMC Oral Health

2021/12/15

Shinsuke Kataoka ¹), Mitsuo Kimura ¹),Tsuguno Yamaguchi ¹), Kenji Egashira ¹),Yu Yamamoto1, Yasushi Koike1 ¹),Yuki Ogawa ¹), Chika Fujiharu ²), Toshiko Namai ²), Kanako Taguchi ²), Momoko Takahashi ²), Asami Kameda ²), Tomoka Kasen ²),Asami Hano ²), Konomi Kubota ²),Masayuki Sato ¹), Hiroaki Yamaga ¹), Kaori Nohara ²), Mikiko Shirasawa ²), Chika Sekine ²), Maki Fukuda ²), Arisa Aoki ²),Yurina Takeuchi ²), Misaki Mugiyama ²), Kenta Mori ⁴), Keigo Sawada ⁴) Yoichiro Kashiwagi　⁴), Masahiro Kitamura ⁴), Takeshi Hayashi ³),Tohru Nakagawa ³), Shinya Murakami ⁴)

1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,
Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

The Japanese Society of Conservative Dentistry

2021/10/28-11/10

Masakazu Ono
Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ～The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

Japanese Society of Pediatric Dentistry

2021/10/17-10/23

Ryosuke Hachisuka
Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

The 64st Autumn Meeting of the Japanese Society of Periodontology

2021/10/15-10/16

Yu Yamamoto
Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

Japanese Association for Oral Biology

2021/10/9-10/11

Yama Kazuma
Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

Japanese Association for Oral Biology

2021/10/9-10/11

Riho Makino
Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

Japanese Association for Oral Biology

2021/10/9-10/11

Mari Yutori
The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

The 14th International Conference of Asian Academy of Preventive Dentistry

2021/10/1-10/3

Taku Iwamoto
The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

The 14th International Conference of Asian Academy of Preventive Dentistry

2021/10/1-10/3

Yukihide Aoyama
Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

The 14th International Conference of Asian Academy of Preventive Dentistry

2021/10/1-10/3

Yasushi Koike
Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

The 14th International Conference of Asian Academy of Preventive Dentistry

2021/10/1-10/3

Kota Tsutumi
The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

PLOS ONE

2021/9/17

Riho Tateyama-Makino ¹), Mari Abe-Yutori ¹), Taku Iwamoto ¹) , Kota Tsutsumi ¹), Motonori Tsuji ²) ,Satoru Morishita ¹), Kei Kurita ¹), Yukio Yamamoto ¹), Eiji Nishinaga ¹),Keiichi Tsukinoki ³)

1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function 3)Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University
Material design of intelligent plastic products with sound generation function due to snap-through buckling

Engineering Research Express, Vol.3 (2021) 015006

2021/5/11

Ryosuke Hachisuka¹),²), Reona Noda ²), Masayuki Yamaguchi ¹)

1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,
Survey on oral care habits and halitosis among general community residents

Annual Meeting of the Japanese Society for Oral Health Care

2021/4/17-4/18

Chiyoko Uchiyama
Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

The Chemical Society of Japan

2021/3/19-3/21

Mari Yutori
The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

The Chemical Society of Japan

2021/3/19-3/21

Riho Makino
The effect of aging on the nanostructure of murine alveolar bone and dentin

Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)

2021/3/11

Chika Akabane ¹),²), Silvia Pabisch ²) , Wolfgang Wagermaier ²), Andreas Roschger ²),³) , Norio Tobori ¹), Tomomichi Okano ¹). Shinya Murakami ⁴), Peter Fratzl ²), Richard Weinkamer ²)

1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan
Comparison of oral microbiome profiles in 18-month-old infants and their parents

Scientific Reports volume 11:861 (2021)

2020/1/13

Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki Research and Development Headquarters, Lion Corporation,
Basic study on staining and removal of dentin by various beverages

Japanese Society for Oral Health

Ayaka Iwasaki
Development of Clinica NEXT STAGE toothbrush

Packaging Technology

2020/12/1

Reona Noda，Shizuka Kawasaki，Ryosuke Hachisuka
Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

Japanese Society for Oral Health

2020/10/20-10/22

Koichiro Hayashi
The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

Japan Academy of Esthetic Dentistry

202010/3-10/4

Ryota Hashimoto
Development of "RePERO", an application to support breath care

The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

2020/9/13-9/16

Kengo Oka
Self-care products：Functions and usefulness of fluoride toothpaste

Society of dental Prctice administration

2020/9/13

Kenichiro Shibasaki
Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

International Conference on Oral Protection Science

2020/7/21-7/24

Yuya Kimoto
Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

The Japanese Society of Conservative Dentistry

2020/6/11-6/12

Rika Oda
Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

the 63rd Spring Meeting of the Japanese Society of Periodontology

2020/5/29-5/30

Kenji Egashira
A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

Japanese Society of Pediatric Dentistry

2020/5/20-5/21

Mai Satake
Gingiva-specific Collagen Gene Regulation by Oxidative Stress

International Association for Dental Research(IADR) 2020

2020/3/18-3/21

Tsuguno Yamagushi
Fluoride and Caries Prevention

Tokyo Medical and Dental University

2020/3/11

Eiji Nishinaga
Fluoride and Caries Prevention

THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY

2020/1/7

Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga
Japan Institute of invention and innovation No.：6591988（Toothbrushes that can limit damage to the user's mouth）

Ryosuke Haschisuka
Asian Pacific Society of Periodontology Meeting 2019　Poster presentation competition Lab research 1st Prize 「Effects of pyrrolidone carboxylic acid on dentin collagen degradation and demineralization」

Shiori Ishii
Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

Scientific Reports 2019 Nov. 9, Article number: 16124

2019/11/6

Ryutaro Jo ¹), Yuichiro Nishimoto ²), Kouta Umezawa ³), KazumaYama ¹), YutoAita ¹), Yuko Ichiba ¹), Shinnosuke Murakami ²),⁴), Yasushi Kakizawa ¹), Takashi Kumagai ³), TakujiYamada ²),⁵),⁶) Shinji Fukuda²),⁴),⁶),⁷),⁸)

1)Research and Development Headquarters, 2)Metabologenomics, Inc.,3)Hiyoshi Oral Health Clinics. ,4)Institute for Advanced Biosciences, Keio University,5)Department of Life Science and Technology, Tokyo Institute of Technology, 6)PRESTO, Japan Science and Technology Agency,8)Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8)Transborder Medical Research Center, University of Tsukuba,
Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

American Society of Human Genetics

2019/10/15-10/19

Satoshi Morishita
Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

Journal of Polymer Research 2019 volume 26, Article number: 246

2019/9/12

Ryosuke Hachisuka ¹)²), Toshiaki Kobayashi ³), Masayuki Yamaguchi ²)

1)School of Materials Science, Japan Advanced Institute of Science and Technology,2)Research & Development Headquarters, Lion Corporation, 3)The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)
A New Method to Speculate Halitosis Level Using Machine Learning

International Association for Dental Research (IADR)

2019/6/19-6/22

Chiaki Michibayashi
Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts―in vitro study

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

2019/03/29

Naho Suzuki
The Journal of Japanese Society of Periodontology, 2019 Journal Award 「Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study」

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

2019/3/29

Naho Suzuki
A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Scientific Reports 2019 9, Article number:3559

2021/12/21-12/23

Yukari Sekine
Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

Annual Meeting of Japanese Society of Public Health

2019/3/5

Takuya Hayakawa ¹), Shizuka Kawasaki ¹), Yutaka Hirayama ¹),TakuyaTsutsui ¹), Eiji Sugiyama ²), KiyoAdachi ¹), Ryo Kon ¹), Makoto Suematsu ²), Yuki Sugiura ²)

1)Research & Development Headquarters, Lion Corporation, 2)Department of Biochemistry, Keio University School of Medicine,
Importance of approaches to the host's defense mechanism in the prevention of periodontal disease and the effects of vitamin E

The 149th Meeting of The Japanese Society of Conservative Dentistry

2018/11/1

Mari Yutori
Evaluation of vitamin-E permeability using human three-dimensional culture epidermis model

The 61st Autumn Meeting of the Japanese Society of Periodontology

2018/10/26-10/27

Kazuaki　Kojima
The wound healing effect of vitamin-E on human gingival fibroblasts

The 61st Autumn Meeting of the Japanese Society of Periodontology

2018/10/26-10/27

Mari Yutori
Effects of copper gluconate on oral malodor

The 61st Autumn Meeting of the Japanese Society of Periodontology

2018/10/26-10/27

Masato Takahashi
Technologies supporting oral care products

Japanese Association for Oral Biology

2018/9/5-9/7

Mari Yutori
Effects of sodium polyacrylate on periodontal disease biofilm in vitro

The Japanese Society of Periodontology

2018/6/1-6/2

Yusuke Kawanobe
THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR Excellent scientific papers First Class 「Decomposition and removal of dental model plaque by using toothpaste containing dextranase」

THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR

2018/4/12

Yuko Aoki 1), Gotaro Izumi 1), Yasuo Nomura 1), Kenichiro Shibasaki 1), 刘婧 2)、李德豹 2)、安丰宝 2) ,郑苏江 3)

1)Lion Corporation 2)獅王日用化工（青島）有限公司 3)中国科学院理化技術研究所