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Body Care

Today, with the rapid changes in social and living environments, and the diversification of values and lifestyles, there is growing interest in maintaining health through self-care. To address the discomforts felt by each and every one of our consumers, we are developing a wide range of products that utilize life science and interface science, as well as bringing together our technological research capabilities cultivated through the development of fundamental technologies, to develop total health care products and services that enable individuals to practice self-care in order to maintain their health and well-being in a natural and positive way.

R&D Case Study

Research Accomplishment—Body Care

Body Care

  • Study of SNPs related to visceral fat reduction effect of lactoferrin

    ifia JAPAN 2023

    2023/05/19

    Ayumi Matsuno

  • Maltotetraose alleviates chronic itch by inhibiting Substance P-Neurokinin 1 receptor pathway

    International Societies for Investigative Dermatology 2023

    2023/05/10

    Keisuke Yoshida

  • Relationship between menstrual pain and related disorders and living behavior in working women

    The 93rd Annual Meeting of the Japanese Society for Hygiene

    2023/03/02

    Kanako Yuyama

  • Young Investigator Excellent Abstract Award
    「A study on the association between anti-obesity effects of lactoferrin and genetic variations」

    22nd IUNS-ICN International Congress of Nutrition
    Young Investigator Excellent Abstract Award

    2022/12/6-12/11

    Kanae Nakamura

  • A study on the association between anti-obesity effects of lactoferrin and genetic variations

    22nd IUNS-ICN International Congress of Nutrition

    2022/12/6-12/11

    Kanae Nakamura

  • Associations between the health benefits of lactoferrin intake and genetic polymorphism

    JSoFF2022

    2022/10/22-10/23

    Daisuke Nishiura

  • "Japan Lactoferrin Society Award Tomita Award" Study of SNPs related to visceral fat reduction effect of lactoferrin

    10th Annual Scientific Meeting "Japan Lactoferrin Society Award Tomita Prize" (Applied category)

    2022/10/15

    Ayumi Matsuno

  • Study of SNPs related to visceral fat reduction effect of lactoferrin

    Japanese Association for Lactoferrin

    2022/10/15

    Ayumi Matsuno

  • Research on the Long-lasting Antibacterial Effects after Using Hand Soap

    Japan Oil Chemists' Society Cleaning & Detergent Division

    2022/10/11-10/14

    Arata Miyachi

  • Research on the Long-lasting Antibacterial Effects after Using Hand Soap

    The Society for Antibacterial and Antifungal Agents, Japan

    2022/9/26-9/27

    Masashi Tachikawa

  • Analysis of the mechanism of individual variabilities in the occurrence of menstrual pain by metabolomics (Part 2) - Clinical study using finger-prick blood metabolomics.

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Kanako Yuyama

  • Analysis of the mechanism of individual variabilities in the occurrence of menstrual pain by metabolomics (Part 1) - Development of finger-prick blood metabolomics.

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Atsushi Sato

  • Characterization of proton T2 relaxation time of bovine lactoferrin powder before and after high-temperature storage

    LWT - Food Science and Technology Volume 163, 15 June 2022, 113521

    2022/6/15

    Takumi Mitsudome

  • Study of SNPs related to visceral fat area and BMI reduction effect of lactoferrin

    The 76th Annual Meeting of Japan Society of Nutrition and Food Science

    2022/6/10-6/12

    Ayumi Matsuno

  • Decreased Frequency of Mental Workload-Induced Subjective Hot Flashes Through Gum Massage: An Open-Label, Self-Controlled Crossover Trial

    Women's Health Reports

    2022/3/8

    Kanako Ichinose

  • Hair evaluation method based on the actual situation of consumers

    The 58th SOCIETY OF COSMETIC CHEMISTS OF JAPAN

    2022/2/18

    Izumi Oishi

  • Well-being as a Key Factor for the Creation of Sustainable Local Towns, People, and Workplaces: An Introduction to Well-being Management Initiatives in Ehime, a Region that Sees a Ray of Light in Solving Local Problems

    Well-being Expo & Conference 2021 Autumn

    2021/11/4-11/5

    Takuya Ichinose

  • Approaches to Visualizing the Effectiveness of Care Focusing on Virus Contact Transmission in the Home

    Symposium on Cleaning

    2021/10/12-10/15

    Keiko Otake

  • Research on the persistence of antibacterial and antiviral effects by hand washing

    Symposium on Cleaning

    2021/10/12-10/15

    Risako Toki

  • Development of materials and functional foods for dry mouth, eyes, and skin (dry syndrome)

    Health ingredients (Hi) Japan 2021 Food ingredients for Taste (FiT) Japan 2021 Safety & Technology (S-tec) Japan 2021 Food Long Life Japan (LL) 2021

    2021/10/6-10/8

    Takao Iwai

  • Proper hand washing, gargling, and disinfection methods and their effects

    The 72nd Divisional Meeting of Division of Colloid and Surface Chemistry

    2021/9/15-9/21

    Yuriko Omoto

  • Development of skin care detergents with excellent moisturizing and tactile properties

    Development and Latest Technology of Moisturizing Cosmetics for Prevention of Rough Skin and Hands

    2021/5/28

    Michihiro Suzuki

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2021

    2021/5/12-5/14

    Tsubasa Yamaguchi

  • Foot trouble due to sweat and odor and development of corresponding products

    FRAGRANCE JOURNAL 2020/3 No.477(Vol.48/No.3)

    2021/3/15

    Shinichi Nagashima

  • Washing Cosmetics

    Basic Cosmetic Technology Seminar

    2021/2/15-2/19

    Risako Toki

  • Technology Introduction of "Nice Slim Essence Lactoferrin" to be delivered to the intestines ~~Visceral Fat Reduction Mechanism and Enteric Coating Technology~

    Japanese Association for lactferrin

    2020/12/6

    Takumi Mitsudome

  • Ideas for preventing infections in the home and workplace, hand washing and cleaning

    The 59th Annual Meeting of the Japan Oil Chemists' Society

    2020/11/2-11/7

    Yukari Sekine

  • Application of Anionic Polymers in Cosmetics

    COSMETIC STAGE 15(1), 45-50, 2020-10

    2020/10/1

    Tomoki Sano

  • Intraoral Approach to Improve the Nasolabial Fold

    COSMETIC STAGE 14(6), 39-45, 2020-08

    2020/8/1

    Yujiro Endo

  • Washing the skin.

    The 119th Annual Meeting of the Japanese Dermatological Association

    2020/6/4-6/7

    Hotaka Asano

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2020

    2020/4/20-4/22

    Takumi Mitsudome

  • Effect of lactoferrin intestinal solvent on visceral fat reduction

    Functional Food Vol.14 No.2 2020

    2020

    Michiaki Murakoshi、Kanae Nakamura、Tomoji Ono

  • Enteric-coated lactoferrin decreases abdominal visceral fat in humans: a randomized, double-blind, placebo-controlled, parallel-group study

    Jpn Pharmacol Ther 2020 48(7)1179 - 1185

    2020

    Satoko Sato 1), Mitsuru Nomura 1), Akira Uchiyama 1), Ikuo Fukuhara 2)

    1)Research & Development Headquarters, Lion Corporation, 2) Fukuhara Clinic, Eniwa,

  • Effects of Coexistent Components on the Antiperspirant Action of Aluminium Chlorohydrate

    J. Soc. Cosmet. Chem. Jpn. 55(1): 45‐51(2020)

    2020

    Tomoki Sano, Wataru Shirae, Yuriko Omoto, Shinichi Nagashima, Atsunori Morigaki, Yasushi Kakizawa, Takaki Ikenishi Research & Development Headquarters, Lion Corporation,

  • A Study on a Longitudinal Evaluation Method Using Facial Expression Analysis to Capture Emotional Changes during Cosmetics Use

    The 18th Conference of the Japanese Society for Cognitive Psychology

    Eisuke Inagaki

  • Rooibos extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulate the M3 muscarinic acetylcholine receptor

    The 7th International Conference on Food Factors (ICoFF2019)

    2019/12/1-12/5

    Takao Iwai

  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    Eur. J. Pharm. Biopharm. Volume146, Jan 2020, Pages 10-18

    2019/11/16

    Takumi Mitsudome 1), Mitsutoshi Moribe 1),Yoshiyuki Obayashi 1), Akira Uchiyama 1),, Megumi Aono 1),

    1) Research & Development Headquarters, Lion Corporation,

  • Rooibos extract activates M3 muscarinic acetylcholine receptor and relieves human dryness

    Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • In vivo mechanism study on the dryness relief function of rooibos extract

    Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • Effects of Rooibos (Aspalathus linearis) Extract on Dryness of Mouth, Eye and Skin in Human

    The 28th Annual Meeting of the Japanese Society for Sjögren's syndrome

    2019/9/13-9/14

    Takao Iwai

  • Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice

    Journal of Oral Biosciences
    Volume 61, Issue 3, September 2019, Pages 179-182

    2019/8/7

    Rieko Arakaki 1), Aya Ushio 1), Satoru Kisoda 1), Mami Sato 1), Yoshitaka Nakamura 2), Kanako Yuyama 2), Riho Tateyama 2), Satoru Morishita 2), Noriyuki Monoi 2), Yasusei Kudo 1), Naozumi Ishimaru 3)

    1)Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences, 2)Research & Development Headquarters, Lion Corporation, 3) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences,

  • Exercise and sports health claims in the system of Foods with Function Claims

    The 19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    2019/6/14-6/16

    Mitsuru Nomura

  • Rooibos (Aspalathus linearis) extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulates exocrine glands via the M 3 muscarinic acetylcholine receptor

    Journal of Functional Foods
    Volume 55, April 2019, Pages 248-254

    2019/2/7

    Saori Nishimachi a),Takao Iwai a), Yoshitaka Nakamura a), Kanako Yuyama-Masuda a), Takuya Tsutsui a),Noriyuki Monoi a), Akira Uchiyama a),b), Seiji Nakamura c),

    a)Research & Development Headquarters, Lion Corporation, b)Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, c)Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University,

  • A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration

    Bioscience, Biotechnology, and Biochemistry, Volume 83, Issue 10, 2019, Pages 1851–1857

    2019/1/4

    Satoko Sato 1), Mitsuru Nomura 1), Ikko Yamana 1), Akira Uchiyama 1), Yasuro Furuichi 2), Yasuko Manabe 2), Nobuharu L Fujii 2),

    1),Research and Development Headquarters, Lion Corporation, 2),Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University ,

  • Relationship between female hormone and hair: Development of hair loss treatment

    The Journal of Japan Hair Science Association Vol.50,No.4(2018)

    2018/12/1

    Shunsuke Hiroshima

  • Quantitative Evaluation of Hair Growth in the Treatment of Hormone Replacement Therapy

    The Japan Society for Menopause and Women's Health

    2018/11/3-11/4

    Yujiro Endo

  • Effect of lactoferrin on energy expenditure enhancement in reprogrammed functional brown adipocytes

    25th International Conference of FFC

    2018/10/27-10/28

    Kanae Nakamura

  • Gene expression order attributed to genome reduction and the steady cellular state in Escherichia coli

    Front. Microbiol., 20 September 2018

    2018/9/20

    Bei-Wen Ying 1),2), Kazuma Yama 3)

    1)Institute of Biology and Information Science, East China Normal University
    2)Faculty of Life and Environmental Sciences, University of Tsukuba
    3)Research & Development Headquarters, Lion Corporation

  • Design of multiscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    2018 SCEJ Autumn Meeting

    2018/9/18-9/20

    Koichiro Nakamura

  • Effects of lactoferrin on lipid metabolism in white adipocytes and brown adipocytes

    FOOD STYLE21

    2018/8/1

    Kanae Nakamura

  • Beta-hydroxy-beta-methylbutyrate (HMB) augments muscle contraction-induced protein synthesis via mTORC1 signaling in cultured L6 myotubes

    Experimental Biology 2018

    2018/4/21-4/25

    Satoko Satoh

  • Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis

    The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/15-3/19

    Satoko Satoh

  • Relationship between female hormone and hair: Development of hair loss treatment

    The Journal of Japan Hair Science Association Vol.51,No.1(2019)

    2018/3/1

    Yujiro Endo

  • Effects of Rooibos(Aspalathus linearis)Extract on Dryness
    of Mouth, Eye and Skin in Human
    ―A Randomized, Double‒blind, Placebo‒controlled Study―

    Jpn Pharmacol Ther 2018 46(6)997 - 1003

    2018

    Takao Iwai

  • Anti-Obesity Effect of Lactoferrin; Subgroup Analysis Excluding Subjects with Obese and/or Hyper-LDL Cholesterolemia

     Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry , Volume 18, Number 1, 2018, pp. 105-109

    2018

    Tomoji Ono 1), Michiaki Murakoshi 1), Akira Uchiyama 1)

    1)Research & Development Headquarters, Lion Corporation

  • The effects of carotenoids intake for improvement of cognitive functions in healthy adults: a systematic review and meta-analysis of randomized controlled trials

    PROSPERO 2018 CRD42018110984

    2018

    Takahiko Suiko

  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes

    BioMetals

    2018

    Kanae Nakamura

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