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In recent years, amid rapid changes in the social environment, consumers’ health consciousness has been steadily increasing. Lion conducts research to ensure a fundamental understanding of both physiological and mental issues with the aim of realizing healthy minds and bodies for all. Oral research, for example, has direct links to such everyday activities as eating, speaking and smiling and is an essential field of study for those looking to facilitate comfortable and fulfilling lives. Lion strives to create new value in areas ranging from oral healthcare products to food and pharmaceuticals by drawing on and combining its 100 years of accumulated research results with a wide range of internal and external technologies.
Developing Pre-Caries Detection Technologies
Gum Disease Prevention Technology Development Focused on the Periodontal Tissue
Skin Research that Draws Out Skin’s Natural Strength
Study of a Specific Example of Genetic Polymorphism—The Relationship between the Function of Enteric-coated Lactoferrin and Single Nucleotide Polymorphisms (SNPs)
Genetic polymorphisms research to provide individualized healthcare based on each person's constitution
Effect of Calcium Fluoride Formation Induced by 1450 ppm Fluoride Treatments on Surface Roughness of Demineralized Enamel
Japanese Society for Dental Health, 2026 April, 76(2)
2025/12/03
Yuma Nakata
Enhanced anti-influenza virus activity of saliva following toothbrushing
Outstanding Paper Award of the Japan Saliva Care Association
2025/11/28
Yusuke Kubo
Accuracy of AI-based binary classification for detecting malocclusion in the mixed dentition stage
PLOS ONE Volume XX（2ー３週間後に出版スケジュールが分かる見込み）
2025/11/27
Kengo Oka
Development of a functional food utilizing the milk protein lactoferrin to reduce visceral fat
26th Commendation for Achievements in Private-Sector Agriculture, Forestry and Fisheries Research and Development (2025) Agriculture, Forestry and Fisheries Research Council Award
2025/11/27
Tomoji Ono
Enhanced anti-influenza virus activity of saliva following toothbrushing
4th Conference of the Japan Saliva Care Association
2025/11/23
Yusuke Kubo
Investigation of the action mechanism of acetaminophen to prevent NSAID-induced small intestinal injury
The 35th Annual Meeting of the Japanese Society of Pharmaceutical Health Care and Sciences
2025/11/23
Keiko Seki
Effect of adding soluble calcium and pyrophosphate to fluoride toothpaste on enamel remineralization
The 163rd Meeting of the Japanese Society of Conservative Dentistry
2025/11/06
Masashi Fujiki
Efficacy of heparinoid and pyridoxine hydrochloride in preventing age-related decline of epidermal tight junction
The Journal of Japanese Society of Aesthetic Dermatology, Vol. 35, No. 3
2025/09/25
Momoyo Nishikawa
Efficacy of heparinoid and pyridoxine hydrochloride in preventing age-related decline of epidermal tight junction
The Journal of Japanese Society of Aesthetic Dermatology, Vol. 35, No. 3
2025/09/25
Momoyo Nishikawa
35th International Federation of Societies of Cosmetic Chemists(IFSCC) in France 2025
Maltotetraose Activate Antioxidative Responses by NRF2 activation in human keratinocytes
2025/09/17
Hitomi Hagawa
FDI World Dental Congress 2025
The clinical effects of toothpaste containing dextranase and IPMP
2025/09/10
Chika Akabane
FDI World Dental Congress 2025
Sodium Pyrrolidone Carboxylate Inhibits Dentin Adhesion of Streptococcus Mutans
2025/09/10
Ryosuke Komatsu
FDI World Dental Congress 2025
Low-intensity blue light enhances whitening effect of hydrogen peroxide.
2025/09/10
Ruiqing Chen
Effect of adding soluble calcium and pyrophosphate to fluoride toothpaste on enamel remineralization: An in vitro study
Archives of Oral Biology, Volume 179, November 2025
2025/08/15
Masashi Fujiki
Deep Learning-Based Visualization of Cutibacterium acnes
Image Laboratory, Vol. 36, No. 8
2025/08/10
Sota Watanabe
Saliva After Toothbrushing Enhances the Inhibitory Effect on the Interaction Between SARS-CoV-2 Spike Protein and Human ACE2 In Vitro
Oral Science International, 2025 Sep, 22(3), e70012.
2025/08/03
Yusuke Kubo
Study on the Mechanism of NSAID-Induced Small Intestinal Injury Suppression by Acetaminophen: Investigation of the Contribution of the Active Metabolite AM404
Ulcer Research Volume 52, Pages 51-56
2025/07/25
Masayoshi Kobayashi
Enhanced anti-influenza virus activity of saliva following toothbrushing
BDJ Open, 2025 Jul 19;11:68.
2025/07/19
Yusuke Kubo
Support service for oral health care habits that nurture children's chewing strength
FOOD Style21 Volume7, No.338
2025/07/01
Kengo Oka, Yuki Yamato
Assessment of nasolabial folds and sagging using images
Skin measurement assessment and visualisation, imaging technology
2025/06/30
Yujiro Endo
Relationship Between Articulatory Clarity during Oral Diadochokinesis and Oral Function
The 36th Annual Meeting of the Japanese Society of Gerodontology
2025/06/29
Mano Ando
630nm-Red-LED promotes collagen synthesis in gingival fibroblasts
103rd General Session & Exhibition of the IADR
2025/06/28
Kenta Hara
Development of an Application for Measuring the Number of Oral Diadochokinesis Pronunciations
The 36th Annual Meeting of the Japanese Society of Gerodontology
2025/06/28
Hiroto Araki
Oxidative Stress Affects Porphyromonas gingivalis LPS-Induced Macrophage Phenotypic Alteration
103rd General Session & Exhibition of the IADR
2025/06/26
Tsuguno Yamaguchi
Effects of After-Toothbrushing Saliva on Anti-Influenza Activity
103rd General Session & Exhibition of the IADR
2025/06/26
Yusuke Kubo
Association between Salivary pH and estimated glomerular filtration rate status in a community-dwelling population: A Cross-sectional Study
Nephron (2025) 149 (9): 519–529.
2025/06/11
Yukihide Aoyama
Skin Barrier Function and Systemic Health
Tokyo University of Pharmacy and Life Sciences Lecture: 'Cosmetic Science'
2025/06/06
Hiroki Sakamoto
Polyoxyethylene and polypropylene emulsification enhances retinol palmitate efficacy in corneal wound healing
Scientific Reports, Volume 15 (1), Article number 17820
2025/05/22
Haruki Horiuchi
Development of a Machine Learning Model for Predicting the Proportion of Beneficial Oral Bacteria from Tongue Images and Lifestyle Questionnaires
The 74th Annual Meeting of the Japanese Society of Oral Health
2025/05/17
Mari Yutori
Comparison of the corneal epithelial wound healing effects of retinyl palmitate (VA pal) and the effectiveness of emulsified VA pal
The 145th Annual Meeting of the Pharmaceutical Society of Japan
2025/03/28
Haruki Horiuchi
Efficacy of combining soluble calcium and pyrophosphate with sodium fluoride in inhibiting enamel caries progression: an in vitro study
Archives of Oral Biology, Volume 171 (2025)
2025/02/28
Masashi Fujiki
Study on the Mechanism of NSAID-Induced Small Intestinal Injury Suppression by Acetaminophen: Investigation of the Contribution of the Active Metabolite AM404
The 52nd Annual Meeting of the Japanese Society of Ulcer Research
2025/02/23
Masayoshi Kobayashi
Nanostructural analysis of age-related changes affecting human dentin
Calcified Tissue International, Volume 116, article number 12 (2025)
2025/01/03
Chika Akabane
Visualization of Cutibacterium acnes from facial images using deep learning
Journal of Japanese Academy of Facial Studies, Vol.24, No.1
2024/12/26
Sota Watanabe
Effect of heparinoid and phospho-pyridoxal on improving the function of tight junction
The 49th Annual Meeting of the Japanese Society for Investigative Dermatology
2024/12/06
Sakamoto Hiroki
Efficacy of combining soluble calcium and pyrophosphate with sodium fluoride in inhibiting enamel caries progression: An in vitro study
Archives of Oral Biology
2024/12/02
Masashi Fujiki
An exploratory study on the relationship between axillary odor and skin condition in adult women
The 2nd Academic Conference of the Society of Cosmetic Chemists of Japan
2024/11/19
Erika Takahashi
Study on the inhibitory mechanism of acetaminophen against NSAID-induced small intestinal injury - Investigation of the action of the active metabolite AM404.
Japanese Association for the Study of Pain
2024/11/16
Keiko Seki
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor regulation -
Ulcer Recearch, Volume 51, p43-49, 2024
2024/09/27
Keiko Seki
Comprehensive Gene Expression Analysis in Aging Models of Taste Bud Organoids
The 58th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2024/09/13
Satoshi Tomeoka
Screening of Components Contributing to the Wnt/β-catenin Signaling Pathway and Evaluation of The Efficacy Using Taste Bud Organoid Aging Models
The 58th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2024/09/13
Yukina Nakatsuji
Ameliorative effects of heparinoid and pyridoxine hydrochloride on age-related decline in skin hydration capacity
The 42nd Annual Meeting of the Japanese Society of Aesthetic Dermatology
2024/08/31
Momoyo Nishikawa
Clinical Evaluation of the Efficacy of Itch-Relief Moisturizers Containing Maltotetraose for Dry, Itchy, and Sensitive Skin
Skinmed, 22(3):187-196
2024/08/02
Eri ichikawa
The mechanism by which acetaminophen prevents NSAIDs-induced small intestinal injury
Medical Science Digest, Volume 50 (8), p27-30, 2024
2024/07/25
Keiko Seki
Suppression of chronic itch by maltotetraose for sensitive skin
7th Intercontinental Personal Care Excellence Conference
2024/06/11
Keisuke Yoshida
Development of novel compounds that can improve skin tight junction integrity
Japanese Dermatological Association
2024/06/06
Sakamoto Hiroki
Dipotassium glycyrrhizate and hinokitiol enhance macrophage efferocytosis by regulating recognition, uptake, and metabolism of apoptotic cells in vitro
Journal of Periodontal Research. 2024 Jun;59(3):542-551.
2024/06
Yu Yamamoto
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor inhibition -
Japan Pharmaceutical Association
2024/05/09
Keiko Seki
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor regulation -
The 46th Meeting of the Japanese Society of Ulcer Research
2024/02/11
Keiko Seki
Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes
Scientific Reports 14, Article number: 3312 (2024)
2024/02/09
Hiroki Sakamoto
A study on menopausal symptoms, menstrual status and subjective well-being in sexually mature and menopausal women
The Japan Society for Menopause and Women's Health
2023/12/02
Yujiro Endo
Relationship between PMS, plasma metabolome, and lifestyle behavior in working women
The Japan Society for Menopause and Women's Health
2023/12/02
Atsushi Sato
Clinical and phototrichogrammatic evaluation of estradiol replacement therapy on hair growth in postmenopausal Japanese women with female pattern hair loss: a pilot study
International Journal of Women’s Dermatology. 9(4):e109, December 2023
2023/12/01
Yujiro Endo
Effect of saliva on suppressing SARS-CoV-2 and influenza virus infection by improving oral hygiene
The 2nd Annual Meeting of the Japan Saliva Care Association Excellent Poster Award
2023/11/26
Taku Iwamoto
Inhibitory Effects of Saliva on SARS-CoV-2 and Influenza Viral Infections by Improving Oral Hygiene
The 71st Annual Meeting of Japanese Association for Dental Research
2023/11/25
Yusuke Kubo
Visualization of infection risk in elementary schools - Estimating factors for the spread of virus infection and effective hygiene behavior -
The 69th Annual Meeting of the Japanese Association of School Health
2023/11/10
Yasuki Kato
Visualization of infection risk in elementary schools - Development of methods for estimating pathogen transmission and evaluating the effect of hygiene behavior -
The 69th Annual Meeting of the Japanese Association of School Health
2023/11/10
Takeshi Takizawa
Inhibitory Effects of Saliva on SARS-CoV-2 and Influenza Viral Infections by Improving Oral Hygiene
The 15th International Conference of the Asian Academy of Preventive Dentistry
2023/11/08
Yusuke Kubo
Effects of a new mouthwash on in vitro dental biofilm model
The 15th International Conference of Asian Academy of Preventive Dentistry
2023/11/08
Kim Ryunhee
The effects of hard gummy candy chewing on oral functions in children
The 34th General Meeting of Japanese Society for Mastication Science and Health Promotion
2023/10/28
Kaichi Hayashi
Metabolite Biomarker Studies of Menstrual Pain Using Plasma Metabolomics
17the Metabolome Symposium
2023/10/18
Atsushi Sato
Integrated analysis of the oral and intestinal microbiome and metabolome of elderly people with more than 26 original teeth: a pilot study
Frontiers in Microbiology
2023/10/12
Yuichiro Nishimoto（Metagen, Inc.）
Kazuma Yama（Lion Corporation）
Relationship between crowding and habits in elementary school children in Kuroishi City, Aomori Prefecture
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Keishi Sato
Effects of Phellodendron bark extract on periodontal pathogenic bacteria in an in vitro oral microbiome model
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Takuma Okuda
Effect of Phellodendron Bark Extract on Bacterial Composition in Oral Biofilm Model
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Kanta Ohara
Dysbiosis of Oral Microbiome Persists After Dental Treatment-Induced Remission of Periodontal Disease and Dental Caries
mSystems Vol.8, No.5
2023/09/12
Kazuma Yama
Suppression of chronic itch by maltotetraose for sensitive skin
The 33rd IFSCC Congress 2023
2023/09/03
Keisuke Yoshida
Impact of ORAL FIT, an oral frailty management service, on training continuity and oral function
The 29th Annual Meeting of the Japanese Society of Dysphagia Rehabilitation
2023/09/02
Yukihide Aoyama
Simulation of virus contact spread in the home when returning home -Visualization of virus spread and hygiene care measures by children and adults-
The 38th Annual Meeting of Japanese Society for infection Prevention and Control
2023/07/20
Yasuki Kato
Caries prevention effect of toothpaste using fluoride deposition technology
The 70th Congress ORCA 2023
2023/07/05
Chika Akabane
EFFICACY OF TOPICAL FORMULAS CONTAINING MALTOTETRAOSE IN TREATING ITCH SENSITIVE SKIN CAUSED BY DRYNESS.
25th World Congress of Dermatology
2023/07/03
Akinori Inoue
Mechanism of itch relief effect by maltotetraose
25th World Congress of Dermatology
2023/07/03
Keisuke Yoshida
Effect of somatosensory stimulation in the oral cavity by tooth brushing behavior on autonomic nerve activity
Japanese Society of Psychosomatic Dentistry
2023/06/30
Asami Miyajima
Stain removal efficacy of toothbrush with elastomer-coated bristles
International Association for Dental Research(IADR)
2023/06/21
Phassamon Piyapakorn
Potassium Nitrate and Aluminum Lactate Containing Toothpaste Reduces Dentin Hypersensitivity
International Association for Dental Research(IADR)
2023/06/21
Taiki Suzuki
Validation of the usefulness of ORAL FIT, an oral frailty management service: A Pilot Study
The 34th Annual Meeting of the Japanese Society of Gerodontology
2023/06/16
Yukihide Aoyama
Plaque Removal Efficacy of New Developed IoT Toothbrush with Brushing Navigation for Children
International Association of Paediatric Dentistry
2023/06/14
Naoshi Kanamaru
Proposal of a simulation model that visualizes the risk of children coming into contact with viruses in elementary schools
The 37th Annual Conference of the Japanese Society for Artificial
2023/06/06
Keisuke Nakajima
Decreased Frequency of Subjective Hot Flashes in Daily Life Through Gum Massage in a Pilot Study ―An Open‒label,Self-controlled Trial―
Jpn Pharmacol Ther 2023 51（6）861 - 869
2023/06/01
Kanako Ichinose
Development and function of "Check-Up toothbrush standard type", a standard toothbrush for caries care
Dental magazine 185
2023/06/01
Kuniyuki Itose, Naoshi Kanamaru
Japanese Society of Periodontology Journal Award 2022 "Allantoin, dipotassium glycyrrhizinate, and azulene sulfonate sodium hydrate inhibit gingival inflammation induced by advanced glycation end products via antiglycation effects in vitro"
JSP Journal Award
2023/05/26
Mari Abe-Yutori
Validation of the usefulness of introducing dental checkups in the workplace
The 66th Spring Meeting of the Japanese Society of Periodontology
2023/05/26
Yu Yamamoto
Effect of encouragement to see a dentist in occupational dental checkups on periodontal disease and systemic health
The 66th Spring Meeting of the Japanese Society of Periodontology
2023/05/26
Kimura Mitsuo
Safety and plaque removal efficacy of Kid’s toothbrush with bendable/unbreakable neck
2023 Central Interntional Dental Exhibition
2023/05/24
Ryosuke Hachisuka
Building a technical foundation for the development of oral care products
The Japan Society for Analytical Chemistry
2023/05/20
Narumi Fujii
Comparison of oral microbiota between oral healthy subjects and periodontal disease patients before and after dental treatment
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Kazuma Yama
Comparison of oral microbiota before and after dental treatment in healthy and carious patients
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Takuya Inokuchi
The relationship between the introduction of dental checkups in the workplace and oral health and productivity
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Yu Yamamoto
Effects of chewing hard gummies on oral function in elementary school children
The 61st Annual Conference of the Japanese Society of Pediatric Dentistry
2023/05/18
Keishi Sato
Women's Health Management Award® 2023 Promotion Award "Well-Being Lounge" Activities
Women's Healthcare Awarenes & Menopause Network Society
2023/03/17
Yujiro Endo
Fluoride and Caries prevention
Tokyo Medical and Dental University
2023/03/15
Chika Akabane
Research on an EIS-type biosensor that detects cortisol in saliva
The 70th JSAP Spring meeting 2023
2023/03/15
Yuki Maruyama
An in vitro study of the effects of Phellodendron bark extract and berberine chloride on periodontal pathogenic bacteria in the oral microbiome
Journal of Oral Biosciences Volume 65, Issue 1, March 2023, Pages 72-79
2023/03/02
Takuma Okuda
Oxidative stress inhibits endotoxin tolerance and may affect periodontitis
Journal of Dental Research 102(3):331-339
2023/03/02
Tsuguno Yamaguchi
Visualization of the Risk and the Care Effects on the Viral Contact Infection in the Home
Transactions of the Japanese Society for Artificial Intelligence 2023 Vol. 38 Iss. 2 p. B-MA6_1-11
2023/03/01
Yukari Sekine
Visualization of Propionibacterium acnes with Visible Light Using Deep Learning
International Workshop on Advanced Image Technology 2023
2023/1/9-1/11
Sota Watanabe
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water
the 1st Annual Meeting of the Japan Saliva Care Research Association
2022/11/27
Yuki Maruyama
Inhibitory effects of toothpaste ingredients on novel coronavirus (SARS-CoV-2) infection in vitro
the 1st Annual Meeting of the Japan Saliva Care Research Association
2022/11/27
Taku Iwamoto
Nanostructural analysis and age-related changes of apatite particles in human dentin
The 44th Annual Meeting of the Japanese Society of Biomaterials
2022/11/21-11/22
Chika Akabane
Age-related changes in mechanical and esthetics properties in human dentin
The 157th Meeting of the Japanese Society of Conservative Dentistry
2022/11/10-11/11
Yuriko Inomata
An in vitro study of the effect of berberine chloride on periodontal pathogenic bacteria in the oral microbiome
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Daisuke Watai
Comparison of oral microbiome profiles in 18-month-old infants and their parents
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Ryutaro Jo
Trends in detection of high prevalent oral bacteria during the first 60 months of life using a next-generation sequencer
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Kazuma Yama
Establishment of oral metabolome profiling method using mouth-rinsed water by capillary electrophoresis–mass spectrometry
The 42nd Symposium on Capillary Electrophoresis (SCE2022)
2022/10/26-10/28
Yuki Maruyama
Relationship between oral care behavior and cold morbidity in workers
The 81st Annual Meeting of Japanese Society of Public Health
2022/10/7-10/9
Ryutaro Jo
The relationship between lifestyle and cold morbidity in workers
The 81st Annual Meeting of Japanese Society of Public Health
2022/10/7-10/9
Ayumi Sawada
evelopment of EIS biosensors for rapid cortisol determination in saliva
2022 International Conference on Solid State Devices and Materials (SSDM2022)
2022/9/26-9/29
Yuki Maruyama
Rapid measurement of EIS biosensors for detecting cortisol concentration in saliva
The 83rd JSAP Autumn meeting 2022
2022/9/20-9/23
Yuki Maruyama
Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (2): Analysis of inter- and intra-day variation of fat-soluble metabolites by liquid chromatography-mass spectrometry
The 16th Metabolome Symposium
2022/9/14-9/16
Narumi Fujii
Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (1): Analysis of inter- and intra-day variation of water-soluble metabolites by capillary electrophoresis–mass spectrometry
The 16th Metabolome Symposium
2022/9/14-9/16
Yuki Maruyama
Antiglycation of periodontitis preventive active ingredients in self-care oral hygiene products
The 65th Autumn Meeting of the Japanese Society of Periodontology
2022/9/2-9/3
Tsuguno Yamaguchi
Phellodendron Bark Extract inhibits osteoclastogenesis by regulation of Nfatc1 gene expression
The 14th Asian Pacific Society of Periodontology Meeting 2022
2022/8/29-8/30
Yu Yamamoto
An in vitro study of effects of Phellodendron Bark Extract on the periodontal pathogenic bacteria in the oral microbiome.
The 14th Asian Pacific Society of Periodontology Meeting 2022
2022/8/29-8/30
Takuma Okuda
The effect of the flavor of children's toothpaste on the tooth-brushing behavior of pre-school children
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Tohru Ohki
The survey of taste sensitivity decrease in healthy subjects:
Relationship between age, taste sensitivity and other factors
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Anna Tsuge
Survey of taste sensitivity decrease in healthy subjects: Study on tastesensitivity decrease and the affecting factors in the 20s
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Satoshi Tomeoka
The 23rd (2021) Oils and Fats Technical Paper Excellence Award 「The inhibitory effects of toothpaste and mouthwash ingredients on the cellular infection process of SARS-CoV-2 infection in vitro」
Oil & Fat Industry Kaikan Award
2022/8/22
Taku Iwamoto
Plaque removal efficacy of bendable/unbreakable safety toothbrush for infant
The 4th International Symposium on Oral Care
2022/7/11
Ryosuke Hachisuka
Comparison of Healthy Versus before/after-Dental Treatment Oral Microbiome
International Association for Dental Research(IADR)
2022/6/20-6/25
Takuya Inokuchi
Effectiveness of the new oral care device for children.
International Association for Dental Research(IADR)
2022/6/20-6/25
Tomonari Kanasugi
Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro
International Association for Dental Research(IADR)
2022/6/20-6/25
Taku Iwamoto
Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro
International Association for Dental Research(IADR)
2022/6/20-6/25
Riho Makino
Virucidal activity of oral care products against enveloped viruses
International Association for Dental Research(IADR)
2022/6/20-6/25
Ryosuke Komatsu
Comparison of Healthy Versus before/after-Dental Treatment Oral Metabolome Profiles
International Association for Dental Research(IADR)
2022/6/20-6/25
Narumi Fujii
Usefulness of Porcine Gingiva for Penetration Tests of Hydrophobic Ingredients
International Association for Dental Research(IADR)
2022/6/20-6/25
Aya Ohkuni
Science behind toothbrush
International Association for Dental Research(IADR)
2022/6/20-6/25
Reona Noda
Plaque removal efficacy of kids’ toothbrush with easily bent neck
International Association for Dental Research(IADR)
2022/6/20-6/25
Sakiho Hayashida
Age-related deterioration of the human dentin
International Association for Dental Research(IADR)
2022/6/20-6/25
Chika Akabane
Study of toothpaste applying fluoride retention and release technology
The 156th Meeting of the Japanese Society of Conservative Dentistry
2022/6/16-7/6
Masashi Fujiki
Simulation modeling of virus contact infection in the home when returning home.
The 37th Annual Meeting of Japanese Society for infection Prevention and Control
2022/6/16-6/18
Yukari Sekine
Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro
European Federation of Periodontology 10th
2022/6/15-6/18
Kota Tsutsumi
Toothpaste technology that cares for the supportive tissue of teeth
Dental Magazine 181 SUMMER
2022/6/1
Yu Yamamoto
Examination of fluoride retention technology of toothpaste using fluoride retention and release technology in the oral cavity
The 71st General meeting of Japanese Society for Oral Health
2022/5/13-5/27
Mari Imazaki
Fluoride retention and release technology contributing to self-care of dental caries prevention
The 71st General meeting of Japanese Society for Oral Health
2022/5/13-5/27
Mari Imazaki
Visualization of infection risk by human behavior analysis and development of virus control technology
The 102nd CSJ Annual Meeting (2022）
2022/3/23-3/26
Takeshi Takizawa
Development of EIS type biosensor to detect cortisol in saliva
The 69th JSAP Spring meeting 2022
2022/3/22-3/26
Yuki Maruyama
The relationship between malocclusion and habits in elementary school children in Kuroishi city, Aomori prefecture
The 92nd Annual Meeting of the Japanese Society for Hygiene
2022/3/21-3/23
Keishi Sato
Fluoride retention and release technology contributing to self-care of dental caries prevention
The Japan Dental Show 2021
2022/3/4-3/6
Mari Imazaki
Fluoride retention and release technology contributing to self-care of dental caries prevention
Dental Magazine 180 SPRING
2022/3/1
Ryota Hashimoto
About the development and function of the nursing care toothbrush "Elac Toothbrush 620" that facilitates oral care for care recipients
Dental Magazine 180 SPRING
2022/3/1
Aya Miyazawa, Naoshi Kanamaru
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water
Scientific Reports 12, Article number: 689 (2022)
2022/1/13
Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)
1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,
Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism
The 80th Annual Meeting of Japanese Society of Public Health
2021/12/21-12/23
Yukari Sekine
A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey
BMC Oral Health
2021/12/15
Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto 1), Yasushi Koike 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)
1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,
Factor analysis of changes in vitality of workers during the COVID-19 pandemic
The 28th Annual Meeting of the Japanese Society for Chronobiology
2021/11/20-11/21
Takahiko Suiko
Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status
The 28th Annual Meeting of the Japanese Society for Chronobiology
2021/11/20-11/21
Ayumi Sawada
Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity
The 155th Meeting of the Japanese Society of Conservative Dentistry
2021/10/28-11/10
Masakazu Ono
Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ～The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.
The 36th Conference of the Japanese Society of Pediatric Dentistry
2021/10/17-10/23
Ryosuke Hachisuka
Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation
The 64th Autumn Meeting of the Japanese Society of Periodontology
2021/10/15-10/16
Yu Yamamoto
Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Kazuma Yama
Inhibitory effects of toothpaste and mouthwash ingredients on SARS CoV 2 priming protease TMPRSS2
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Riho Makino
Inhibitory effects of toothpaste and mouthwash ingredients on
the interaction between S-protein of SARS-CoV-2 and ACE2
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Mari Yutori
The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Taku Iwamoto
The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Yukihide Aoyama
Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Yasushi Koike
Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Kota Tsutsumi
Sleep Quality and Productivity Decline under a New Coronavirus Infection Epidemic
The 46th Annual Meeting of Japanese Society of Sleep Research
2021/9/23-9/24
Yuki Nagamori
Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status
The 46th Annual Meeting of Japanese Society of Sleep Research
2021/9/23-9/24
Ayumi Sawada
Let's do what we want to do with good sleep habits! ～What I've learned from sleep research
11th CSJ Chemistry Festa
2021/9/22-9/24
Takao Iwai
The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro
PLOS ONE 2021; 16(9): e0257705.
2021/9/17
Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1), Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)
1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function
3)Division of Environmental Pathology, Department of Oral
Science, Kanagawa Dental University
Functionality of Sake Yeast -Improvement of Sleep Quality
23th Joint Yeast Symposium
2021/9/2-9/3
Tomomi Sano
Association between frequency of tooth brushing and health-related factors among workers
Annual Meeting of the Japanese Society of Time-based Nutrition
2021/8/27-8/28
Takao Iwai
Development of an original in vitro exercise model and its application to the analysis of the mechanism of action of β-hydroxy-β-methylbutyrate (HMB)
The 29th Annual Meeting of Japan Society of Exercise and Sports Physiology
2021/8/20-8/21
Satoko Satoh
Irregular meal timing is associated to the mental health in Japanese workers.
Nutrients 2021, 13(8), 2775
2021/8/13
Yu Tahara 1), Saneyuki Makino 1), Takahiko Suiko 2), Yuki Nagamori 2), Takao Iwai 2), Megumi Aono 2), and Shi-genobu Shibata 1),
1 Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda Univer-sity 2 Research and Development Headquarters, Lion Corporation
Improving sleep and productivity with solutions tailored to each person's sleep state
Online seminar to introduce health management solutions([Organizer] Fair Work Co.)
2021/6/29
Takuya Ichinose
Basic study on staining and removal of dentin by various beverages
The 70th General meeting of Japanese Society for Oral Health
2021/5/27-6/10
Ayaka Iwasaki
Material design of intelligent plastic products with sound generation function due to snap-through buckling
2021 Eng. Res. Express 3 015006
2021/5/11
Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)
1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,
Survey on oral care habits and halitosis among general community residents
The 18th Annual Meeting of the Japanese Society of Oral Care
2021/4/17-4/18
Chiyoko Uchiyama
Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage
The 141st Annual Meeting of the Pharmaceutical Society of Japan
2021/3/26-3/29
Takumi Mitsudome
Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2
The 101st CSJ Annual Meeting (2021）
2021/3/19-3/21
Mari Yutori
The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection
The 101st CSJ Annual Meeting (2021）
2021/3/19-3/21
Riho Makino
The effect of aging on the nanostructure of murine alveolar bone and dentin
Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)
2021/3/11
Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)
1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan
"BtoBtoC business that aims to improve health and work productivity through better sleep."
Kenkojumyo Report
2021/3/4
Megumi Aono