Close

Oral Technology

Eating, speaking, laughing—these and other functions of the mouth are crucial to our ability to live comfortably and enjoyably. Lion’s oral science research goes back more than a century. Aiming to improve consumers’ quality of life (QOL), we continue to build on this wealth of knowledge with research in such areas as non-destructive methods of treating dental caries, ways to reduce gingival inflammation based on molecular cytology, and the suppression of bacterial growth using proprietary biofilm models. In recent years, Lion has also partnered with external research institutions to elucidate the influence that conditions in the oral cavity have on the body’s overall health through joint research. By combining a wide range of technologies from in and outside the Lion Group, chiefly in the area of oral science, we strive to create new value through products ranging from those for oral care to food and pharmaceuticals.

R&D Case Study

Research Accomplishment—Oral Technology

  • Age-related deterioration of the human dentin

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Chika Akabane

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro

    European Federation of Periodontology 10th

    2022/6/15-6/18

    Kota Tsutsumi

  • Development of EIS type biosensor to detect cortisol in saliva

    The 69th Japan Society of Applied Physics Spring Meeting

    2022/3/22-3/26

    Yuki Maruyama

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports 2022 12, Article number:689

    2022/1/13

    Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)

    1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health

    2021/12/21-12/23

    Yukari Sekine

  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health

    2021/12/15

    Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto1, Yasushi Koike1 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)

    1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,

  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The Japanese Society of Conservative Dentistry

    2021/10/28-11/10

    Masakazu Ono

  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    Japanese Society of Pediatric Dentistry

    2021/10/17-10/23

    Ryosuke Hachisuka

  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64st Autumn Meeting of the Japanese Society of Periodontology

    2021/10/15-10/16

    Yu Yamamoto

  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Yama Kazuma

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Riho Makino

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    Japanese Association for Oral Biology

    2021/10/9-10/11

    Mari Yutori

  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Taku Iwamoto

  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yukihide Aoyama

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yasushi Koike

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Kota Tsutumi

  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE

    2021/9/17

    Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1) , Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)

    1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function 3)Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University

  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    Engineering Research Express, Vol.3 (2021) 015006

    2021/5/11

    Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,

  • Survey on oral care habits and halitosis among general community residents

    Annual Meeting of the Japanese Society for Oral Health Care

    2021/4/17-4/18

    Chiyoko Uchiyama

  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The Chemical Society of Japan

    2021/3/19-3/21

    Mari Yutori

  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The Chemical Society of Japan

    2021/3/19-3/21

    Riho Makino

  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)

    2021/3/11

    Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports volume 11:861 (2021)

    2020/1/13

    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki Research and Development Headquarters, Lion Corporation,

  • Basic study on staining and removal of dentin by various beverages

    Japanese Society for Oral Health

    Ayaka Iwasaki

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology

    2020/12/1

    Reona Noda,Shizuka Kawasaki,Ryosuke Hachisuka

  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    Japanese Society for Oral Health

    2020/10/20-10/22

    Koichiro Hayashi

  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    Japan Academy of Esthetic Dentistry

    202010/3-10/4

    Ryota Hashimoto

  • Development of "RePERO", an application to support breath care

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

    2020/9/13-9/16

    Kengo Oka

  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration

    2020/9/13

    Kenichiro Shibasaki

  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science

    2020/7/21-7/24

    Yuya Kimoto

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The Japanese Society of Conservative Dentistry

    2020/6/11-6/12

    Rika Oda

  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    the 63rd Spring Meeting of the Japanese Society of Periodontology

    2020/5/29-5/30

    Kenji Egashira

  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    Japanese Society of Pediatric Dentistry

    2020/5/20-5/21

    Mai Satake

  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research(IADR) 2020

    2020/3/18-3/21

    Tsuguno Yamagushi

  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University

    2020/3/11

    Eiji Nishinaga

  • Fluoride and Caries Prevention

    THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY

    2020/1/7

    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

  • Japan Institute of invention and innovation No.:6591988(Toothbrushes that can limit damage to the user's mouth)

    Ryosuke Haschisuka

  • Asian Pacific Society of Periodontology Meeting 2019 Poster presentation competition Lab research 1st Prize 「Effects of pyrrolidone carboxylic acid on dentin collagen degradation and demineralization」

    Shiori Ishii

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports 2019 Nov. 9, Article number: 16124

    2019/11/6

    Ryutaro Jo 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), KazumaYama 1), YutoAita 1), Yuko Ichiba 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1), Takashi Kumagai 3), TakujiYamada 2),5),6) Shinji Fukuda2),4),6),7),8)

    1)Research and Development Headquarters, 2)Metabologenomics, Inc.,3)Hiyoshi Oral Health Clinics. ,4)Institute for Advanced Biosciences, Keio University,5)Department of Life Science and Technology, Tokyo Institute of Technology, 6)PRESTO, Japan Science and Technology Agency,8)Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8)Transborder Medical Research Center, University of Tsukuba,

  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics

    2019/10/15-10/19

    Satoshi Morishita

  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research 2019 volume 26, Article number: 246

    2019/9/12

    Ryosuke Hachisuka 1)2), Toshiaki Kobayashi 3), Masayuki Yamaguchi 2)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology,2)Research & Development Headquarters, Lion Corporation, 3)The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)

  • A New Method to Speculate Halitosis Level Using Machine Learning

    International Association for Dental Research (IADR)

    2019/6/19-6/22

    Chiaki Michibayashi

  • Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts―in vitro study

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/03/29

    Naho Suzuki

  • The Journal of Japanese Society of Periodontology, 2019 Journal Award 「Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study」

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports 2019 9, Article number:3559

    2021/12/21-12/23

    Yukari Sekine

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health

    2019/3/5

    Takuya Hayakawa 1), Shizuka Kawasaki 1), Yutaka Hirayama 1),TakuyaTsutsui 1), Eiji Sugiyama 2), KiyoAdachi 1), Ryo Kon 1), Makoto Suematsu 2), Yuki Sugiura 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biochemistry, Keio University School of Medicine,

  • Importance of approaches to the host's defense mechanism in the prevention of periodontal disease and the effects of vitamin E

    The 149th Meeting of The Japanese Society of Conservative Dentistry

    2018/11/1

    Mari Yutori

  • Evaluation of vitamin-E permeability using human three-dimensional culture epidermis model

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Kazuaki Kojima

  • The wound healing effect of vitamin-E on human gingival fibroblasts

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Mari Yutori

  • Effects of copper gluconate on oral malodor

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Masato Takahashi

  • Technologies supporting oral care products

    Japanese Association for Oral Biology

    2018/9/5-9/7

    Mari Yutori

  • Effects of sodium polyacrylate on periodontal disease biofilm in vitro

    The Japanese Society of Periodontology

    2018/6/1-6/2

    Yusuke Kawanobe

  • THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR Excellent scientific papers First Class 「Decomposition and removal of dental model plaque by using toothpaste containing dextranase」

    THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR

    2018/4/12

    Yuko Aoki 1), Gotaro Izumi 1), Yasuo Nomura 1), Kenichiro Shibasaki 1), 刘婧 2)、李德豹 2)、安丰宝 2) ,郑苏江 3)

    1)Lion Corporation 2)獅王日用化工(青島)有限公司 3)中国科学院理化技術研究所

Share