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As self-medication grows more common, consumers’ health-related needs are diversifying. In response, Lion is constantly working to develop highly functional products that leverage its proprietary technologies. This approach enables Lion to create products that have a unique market position. For example, Lion has used its proprietary technologies related to quickly dissolving active ingredients in the development of BUFFERIN analgesics and cold medicine. Lion’s technologies for the stable formulation of vitamin A have been used in Smile eye drops. And Stoppa antidiarrheal products employ Lion’s oral medicine fast-disintegration technology, for relief whenever needed with just one tablet that can be taken without water. Going forward, Lion will continue to actively develop products based on its unique proprietary technologies.
Antipyretic Analgesic Development Based on Customer Needs
Taking a Scientific Approach to Create a Better Cold Medicine
The Story Behind the Development of Smile
Investigation of the action mechanism of acetaminophen to prevent NSAID-induced small intestinal injury
The 35th Annual Meeting of the Japanese Society of Pharmaceutical Health Care and Sciences
2025/11/23
Keiko Seki
Functions of Macrophages in Periodontal Disease Progression and Gingival Tissue Homeostasis
Advances in Experimental Medicine and Biology "Oral Immunology"
2025/11/14
Tsuguno Yamaguchi
Identification of Metabolite Biomarkers Associated with the Severity of Menstrual Pain Using finger-prick Blood
The 19th Metabolome Symposium
2025/10/15
Atsushi Sato
Efficacy of heparinoid and pyridoxine hydrochloride in preventing age-related decline of epidermal tight junction
The Journal of Japanese Society of Aesthetic Dermatology, Vol. 35, No. 3
2025/09/25
Momoyo Nishikawa
Biomembrane permeation of non-steroidal anti-inflammatory drugs: Influence of molecular structure
The 76th Division Meeting of Division of Colloid and Surface Chemistry
2025/09/22
Akira Sorada
Lipid membrane permeation of lipophilic substances through cholic salt micelles: Influence of molecular structure of lipophilic substances
39th Conference of the European Colloid & Interface Society
2025/09/09
Akira Sorada (Joint research with Tokyo University of Science)
Lipid membrane permeation of lipophilic substances through cholic salt micelles: Influence of molecular structure of lipophilic substances
The 63rd Annual Meeting of the Japan Oil Chemists' Society
2025/09/03
Akira Sorada (Joint research with Tokyo University of Science)
Deep Learning-Based Visualization of Cutibacterium acnes
Image Laboratory, Vol. 36, No. 8
2025/08/10
Sota Watanabe
Study on the Mechanism of NSAID-Induced Small Intestinal Injury Suppression by Acetaminophen: Investigation of the Contribution of the Active Metabolite AM404
Ulcer Research Volume 52, Pages 51-56
2025/07/25
Masayoshi Kobayashi
Skin Barrier Function and Systemic Health
Tokyo University of Pharmacy and Life Sciences Lecture: 'Cosmetic Science'
2025/06/06
Hiroki Sakamoto
Polyoxyethylene and polypropylene emulsification enhances retinol palmitate efficacy in corneal wound healing
Scientific Reports, Volume 15 (1), Article number 17820
2025/05/22
Haruki Horiuchi
Comparison of the corneal epithelial wound healing effects of retinyl palmitate (VA pal) and the effectiveness of emulsified VA pal
The 145th Annual Meeting of the Pharmaceutical Society of Japan
2025/03/28
Haruki Horiuchi
Study on the Mechanism of NSAID-Induced Small Intestinal Injury Suppression by Acetaminophen: Investigation of the Contribution of the Active Metabolite AM404
The 52nd Annual Meeting of the Japanese Society of Ulcer Research
2025/02/23
Masayoshi Kobayashi
Branched-chain amino acids and specific phosphatidylinositols are plasma metabolite pairs associated with menstrual pain severity
Scientific Reports, 15, 3194(2025)
2025/01/25
Atsushi Sato
Visualization of Cutibacterium acnes from facial images using deep learning
Journal of Japanese Academy of Facial Studies, Vol.24, No.1
2024/12/26
Sota Watanabe
Effect of heparinoid and phospho-pyridoxal on improving the function of tight junction
The 49th Annual Meeting of the Japanese Society for Investigative Dermatology
2024/12/06
Sakamoto Hiroki
Study on the inhibitory mechanism of acetaminophen against NSAID-induced small intestinal injury - Investigation of the action of the active metabolite AM404.
Japanese Association for the Study of Pain
2024/11/16
Keiko Seki
Smile Cornea Checker – An AI-powered Online Tool for Corneal Health Assessment
Japan Society for the Promotion of Science R021 Food and Preventive Markers Industry-Academia Collaboration Committee (10/28) 22nd Regular Research Meeting
2024/10/28
Takahiko Suiko
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor regulation -
Ulcer Recearch, Volume 51, p43-49, 2024
2024/09/27
Keiko Seki
Ameliorative effects of heparinoid and pyridoxine hydrochloride on age-related decline in skin hydration capacity
The 42nd Annual Meeting of the Japanese Society of Aesthetic Dermatology
2024/08/31
Momoyo Nishikawa
The mechanism by which acetaminophen prevents NSAIDs-induced small intestinal injury
Medical Science Digest, Volume 50 (8), p27-30, 2024
2024/07/25
Keiko Seki
Smile Cornea Checker – An AI-powered Online Tool for Corneal Health Assessment
"Biotechnology for the Future" Seminar: AI Utilization Series 6: Health Check and Pre-Symptomatic Diagnosis
2024/07/18
Takahiko Suiko
Development of novel compounds that can improve skin tight junction integrity
Japanese Dermatological Association
2024/06/06
Sakamoto Hiroki
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor inhibition -
Japan Pharmaceutical Association
2024/05/09
Keiko Seki
Examining the mechanism by which acetaminophen suppresses NSAIDs-induced gastrointestinal injury - Verifying the possibility of suppressing injury through serotonin receptor regulation -
The 46th Meeting of the Japanese Society of Ulcer Research
2024/02/11
Keiko Seki
Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes
Scientific Reports 14, Article number: 3312 (2024)
2023/12/08
Hiroki Sakamoto
Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen - Verification of the possibility of suppressing injury by controlling serotonin receptors -
The 45th Annual Meeting of Japanese Association for the Study of Pain
2024/02/09
Keiko Seki
Investigation of the inhibitory action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury
The 109th General Meeting of the Japanese Society of Gastroenterology
2023/04/06
Ryuto Kimura
Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal damage by acetaminophen
Ulcer Research Vol 50 28-34
2023/08/10
Masayoshi Kobayashi
Examination of irritant factors affecting corneal epithelial repair and corneal epithelial repair effect of retinol palmitate
The 143rd Annual Meeting of the Pharmaceutical Society of Japan
2023/03/25
Haruki Horiuchi
Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen
The 50th Meeting of the Japanese Society of Ulcer Research
2023/02/03
Masayoshi Kobayashi
Examination of the inhibitory mechanism of NSAIDs-induced gastrointestinal mucosal damage by acetaminophen
The 44th Annual Meeting of Japanese Association for the Study of Pain
2022/12/2-12/3
Keiko Seki
Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury
Ulcer Research Vol 49 10-15
2022/10/25
Keiko Seki
Relationship between changes in the intestinal microbiome and the protective effect of acetaminophen against NSAIDs-induced small Intestinal mucosal damage
Ulcer Research Vol 49 45-48
2022/10/25
Yuto Aita
The effects of sucralfate on chronic stress-induced duodenal low-grade inflammation
Jpn Pharmacol Ther 2022 50（6）1003 - 1011
2022/6/20
Mayumi Tsuri
Japanese Sake Yeast Improves the Quality of Sleep
Journal of the Brewing Society of Japan
2022/4/1
Tomomi Sano
Relationship between NSAIDs-induced small intestinal mucosal injury and microbiome -Elucidation of the injury suppression mechanism by acetaminophen-
The 108th General Meeting of the Japanese Society of Gastroenterology
2022/4/21-4/23
Yuto Aita
Investigation of the inhibitory action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury
The 108th General Meeting of the Japanese Society of Gastroenterology
2022/4/21-4/23
Keiko Seki
Received the 49th Meeting of the Japanese Society of Ulcer Research (2022) Encouragement Award
「Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury」
The 49th Meeting of the Japanese Society of Ulcer Research Encouragement Award
2022/2/11-2/13
Keiko Seki
Elucidation of the relationship between suppression of NSAIDs-induced small intestinal injury by acetaminophen and bacterial flora
The 49th Meeting of the Japanese Society of Ulcer Research
2022/2/11-2/13
Yuto Aita
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction
The Ocular Surface
2021/10/16
Tomo Suzuki a),b),Koji Kitazawa a), Yuko Cho a),b), Masataka Yoshida c), Takashi Okumura c), Atsushi Sato c), Shigeru Kinoshita d)
a) Department of Ophthalmology, Kyoto Prefectural University of Medicine
b) Department of Ophthalmology, Kyoto City Hospital Organization
c) Research and Development Headquarters, Lion Corporation,
d) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural
University of Medicine
Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate
The 54th JPA Congress of Pharmacy and Pharmaceutical Science
2021/9/19-9/20
Yasushi Kudo
Usefulness of acetaminophen in ibuprofen-induced small bowel injury
(Journal of Japanese Society of Gastroenterology) Nihon Shokakibyo Gakkai Zasshi. 2021;118(9):840-850
2021/9/10
Miyu Kitahara, Yuki Sakamoto, Ryuto Kimura, Keiko Seki
Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil
Translational Vision Science & Technology Volume 10(21); 2021 April
2021/4/20
Keisuke Watanabe 1), Masataka Yoshida 1), Takashi Okumura 1), Takayuki Sassa 2), Akio Kihara 2), Akira Uchiyama 1)
1) Research and Development Headquarters, Lion Corporation, 2)Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences
Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen
The 107th General Meeting of the Japanese Society of Gastroenterology
2021/4/15-4/17
Keiko Seki
Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora
The 107th General Meeting of the Japanese Society of Gastroenterology
2021/4/15-4/17
Yuto Aita