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In recent years, with the diversification of lifestyles and values as well as the aging of the population and increase in average life expectancy, oral healthcare has become increasingly important part of maintaining quality of life. Against this backdrop, Lion will continue to create new value that goes beyond existing frameworks by bringing together the fundamental technologies and R&D capabilities it has cultivated over 120 years as Japan’s No. 1 oral healthcare manufacturer. We are developing products and services that lead to better oral and overall health, as well as improved quality of life.
Toothbrush Technology and Manufacturing Method ~Debut of New Material Rubber Head Toothbrush~
Toward a Society where Appropriate Oral Healthcare Can Be Realized for Everyone, Anytime, Anywhere Activities for Creating Better Living Habits in Space
Super-Tapered Bristle Toothbrushes for Periodontal Pocket Care
Reach the Backs of the Back Molars!
Development of STEP Toothbrushes Tailored to Specific Stages of Children’s Growth
Overseas Roll Out of Super Thin Head, Slim Neck Toothbrushes Developed in Japan
Utilizing Gum Disease Prevention Technologies with the Keyword “Plaque”
Preventive Dentistry Initiatives in Asia
Advanced Research on Oral Health Care Utilizing CE-MS metabolomics at Lion Corporation
The 45th Capillary Electrophoresis Symposium
2025/12/12
Narumi Fujii
Effect of Calcium Fluoride Formation Induced by 1450 ppm Fluoride Treatments on Surface Roughness of Demineralized Enamel
Japanese Society for Dental Health, 2026 April, 76(2)
2025/12/03
Yuma Nakata
Enhanced anti-influenza virus activity of saliva following toothbrushing
Outstanding Paper Award of the Japan Saliva Care Association
2025/11/28
Yusuke Kubo
Accuracy of AI-based binary classification for detecting malocclusion in the mixed dentition stage
PLOS ONE Volume XX（2ー３週間後に出版スケジュールが分かる見込み）
2025/11/27
Kengo Oka
Enhanced anti-influenza virus activity of saliva following toothbrushing
4th Conference of the Japan Saliva Care Association
2025/11/23
Yusuke Kubo
Functions of Macrophages in Periodontal Disease Progression and Gingival Tissue Homeostasis
Advances in Experimental Medicine and Biology "Oral Immunology"
2025/11/14
Tsuguno Yamaguchi
Effect of phosphate in fluoride-calcium-phosphate complexes on fluoride retention in the oral cavity.
The 47th Annual Meeting of Japanese Society tof Biomaterials
2025/11/11
Hikaru Takabayashi
Effect of adding soluble calcium and pyrophosphate to fluoride toothpaste on enamel remineralization
The 163rd Meeting of the Japanese Society of Conservative Dentistry
2025/11/06
Masashi Fujiki
Evaluation of Oral Microbiota Modulation by Dipotassium Glycyrrhizinate
The 163rd Meeting of the Japanese Society of Conservative Dentistry
2025/11/06
Takuma Okuda
Effects of Dipotassium Glycyrrhizate on Dysbiosis of Polymicrobial Biofilm Model
The 68th Autumn Meeting of the Japanese Society of Periodontology
2025/10/17
Kanta Ohara
Association between oral diadochokinesis, grade, and sex in Japanese elementary school children in Kuroishi, Aomori
The 89th National School Dental Health Research Conference
2025/10/16
Kaichi Hayashi
Development of high-throughput and quantitative analytical methods for the determination of pathogenic metabolites in culture media of periodontitis-associated bacteria
The 19th Metabolome Symposium
2025/10/15
Daiki Hashimoto
Study of Toothbrush Factors Influencing Both Cleaning Efficacy and Gentleness
FDI World Dental Congress 2025
2025/09/12
Yuichiro Kakehashi
Optimization of Whitening Toothpaste Using Artificial Intelligence-Based Bayesian Optimization
FDI World Dental Congress 2025
2025/09/11
Ryunhee Kim
FDI World Dental Congress 2025
The clinical effects of toothpaste containing dextranase and IPMP
2025/09/10
Chika Akabane
FDI World Dental Congress 2025
Sodium Pyrrolidone Carboxylate Inhibits Dentin Adhesion of Streptococcus Mutans
2025/09/10
Ryosuke Komatsu
FDI World Dental Congress 2025
Low-intensity blue light enhances whitening effect of hydrogen peroxide.
2025/09/10
Ruiqing Chen
Analysis of the Relationship Between Oral Microbiota Composition and the Diversity and Bacterial Profiles of the Gut Microbiota
The 67th Annual Meeting of the Japanese Association for Oral Biology
2025/09/05
Kazuma Yama
Development and Validation of a Web-Based Application for Assessing Oral Diadochokinesis
17th International Conference of the Asian Academy of Preventive Dentistry
2025/09/03
Satoshi Tomeoka
Effectiveness of Chewing Hard Gummy Candy to Enhance Masticatory Function in Japanese Children
17th International Conference of the Asian Academy of Preventive Dentistry
2025/09/03
Keishi Sato
[Panel Discussion] International Expansion of Well-Being Management from Japan: Sharing Insights to Promote Global Social Health
[Pre-Seminar] Well-Being Beauty 2025
2025/09/03
Noriyuki Monoi
Preventive Effect of Toothpaste Containing Calcium and Phosphate Ions Combined with Sodium Pyrrolidone Carboxylate on Root Dentin Demineralization
17th International Conference of Asian Academy of Preventive Density
2025/09/03
Ryohei Nakada
Effect of adding soluble calcium and pyrophosphate to fluoride toothpaste on enamel remineralization: An in vitro study
Archives of Oral Biology, Volume 179, November 2025
2025/08/15
Masashi Fujiki
Saliva After Toothbrushing Enhances the Inhibitory Effect on the Interaction Between SARS-CoV-2 Spike Protein and Human ACE2 In Vitro
Oral Science International, 2025 Sep, 22(3), e70012.
2025/08/03
Yusuke Kubo
Enhanced anti-influenza virus activity of saliva following toothbrushing
BDJ Open, 2025 Jul 19;11:68.
2025/07/19
Yusuke Kubo
Support service for oral health care habits that nurture children's chewing strength
FOOD Style21 Volume7, No.338
2025/07/01
Kengo Oka, Yuki Yamato
Relationship Between Articulatory Clarity during Oral Diadochokinesis and Oral Function
The 36th Annual Meeting of the Japanese Society of Gerodontology
2025/06/29
Mano Ando
Effectiveness of an Oral Frailty Intervention Program for Clinic Outpatients
The 36th Annual Meeting of the Japanese Society of Gerodontology
2025/06/29
Yukihide Aoyama
630nm-Red-LED promotes collagen synthesis in gingival fibroblasts
103rd General Session & Exhibition of the IADR
2025/06/28
Kenta Hara
Development of an Application for Measuring the Number of Oral Diadochokinesis Pronunciations
The 36th Annual Meeting of the Japanese Society of Gerodontology
2025/06/28
Hiroto Araki
Dipotassium Glycyrrhizate Inhibits Dysbiosis Through the Selective Antibacterial Effects
103rd General Session & Exhibition of the IADR
2025/06/27
Kanta Ohara
Oxidative Stress Affects Porphyromonas gingivalis LPS-Induced Macrophage Phenotypic Alteration
103rd General Session & Exhibition of the IADR
2025/06/26
Tsuguno Yamaguchi
Effects of After-Toothbrushing Saliva on Anti-Influenza Activity
103rd General Session & Exhibition of the IADR
2025/06/26
Yusuke Kubo
Identification of oral metabolites associated with pathogenicity against human gingival epithelial cells
The 25th Annual Meeting of the Japan Society of Anti-Aging Medicine
2025/06/14
Misato Sako
Adoption and Utilization of High-Throughput Metabolomics at Lion Corporation
The 85th Symposium of the Japan Society for Analytical Chemistry
2025/06/01
Narumi Fujii
Identification of Oral Bacteria and Metabolites Associated with Periodontal Disease
The 98th Annual Meeting of the Japanese Society for Bacteriology
2025/05/30
Chikako Ishihara
Investigation of the Transition Period to Individual-Specific Oral Microbiota in Young Children
The 63rd Annual Meeting of the Japanese Society of Pediatric Dentistry
2025/05/29
Yuto Fujii
Development of a Machine Learning Model for Predicting the Proportion of Beneficial Oral Bacteria from Tongue Images and Lifestyle Questionnaires
The 74th Annual Meeting of the Japanese Society of Oral Health
2025/05/17
Mari Yutori
The Relationship Between Oral Health and Overall Health Starting from Dental Checkups in the Working-Age Population
Public Symposium of the Science Council of Japan: "Considering the Importance of Nationwide Dental Checkups"
2025/05/17
Mitsuo Kimura
Study on the Effects of a Dental Checkup with Awareness-raising Measures on Changes in the Oral Health Behavior of the Japanese Working-age Population
The Japanese Journal of Conservative Dentistry, Vol. 68, No. 2, pp. 83-92
2025/05/07
Koichiro Hayashi
Phellodendron bark extract and berberine chloride suppress microbiome dysbiosis in a saliva-derived in vitro microcosm biofilm model
Archives of Oral Biology, 174, 106231(2025)
2025/03/22
Takuya Inokuchi
Oral Microbiota Development in the First 60 Months: A Longitudinal Study
The 11th Japanese Pediatric Multidisciplinary Conference
2025/03/09
Daisuke Watai
Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression
Scientific Reports, 15, 7149(2025)
2025/02/28
Chikako Ishihara
Efficacy of combining soluble calcium and pyrophosphate with sodium fluoride in inhibiting enamel caries progression: an in vitro study
Archives of Oral Biology, Volume 171 (2025)
2025/02/28
Masashi Fujiki
Intra- and inter-day variations in oral metabolites from mouth-rinsed water determined using capillary electrophoresis–mass spectrometry metabolomics
Clinica Chimica Acta Volume 565, Pages 119965
2025/01/15
Yuki Maruyama
Nanostructural analysis of age-related changes affecting human dentin
Calcified Tissue International, Volume 116, article number 12 (2025)
2025/01/03
Chika Akabane
Efficacy of combining soluble calcium and pyrophosphate with sodium fluoride in inhibiting enamel caries progression: An in vitro study
Archives of Oral Biology
2024/12/02
Masashi Fujiki
Technological Approaches for Root Caries Prevention: Utilizing High-Fluoride Retention Technology (F-Ca-P) and Collagen-Protective Agent Sodium DL-Pyrrolidone Carboxylate (PCA)
Dental Magazine 191 WINTER
2024/12/01
Kohei Ishii
A technological approach to prevent root caries - Utilizing high fluoride retention technology F-Ca-P and collagen protection component DL-sodium pyrrolidone carboxylate (PCA) -
Dental Magazine
2024/12/01
Saliva Multi Test system (SMT) - A saliva test system that redesigns preventive dental habits -
The 3rd Annual Meeting of Japan Saliva Care Association Luncheon Seminar
2024/11/23
Chiyoko Uchiyama
Root Caries Preventive Effect of Toothpaste Containing Fluoride Retention-Release Technology and Collagen Protection Technology
161st Annual Meeting of the Japanese Academy of Conservative Dentistry, Fall 2024
2024/11/22
Ryohei Nakada
Effects of Sodium Pyrrolidone Carboxylate (PCA-Na) on Streptococcus mutans
16th Asian Academy of Preventive Dentistry (AAPD 2024)
2024/11/18-19
Ryosuke Komatsu
Significance of the dental checkup in workplace on oral and general health
AAPD2024（The 16th International Conference of the Asian Academy of Preventive Dentistry）
2024/11/18
Yu Yamamoto
The effects of dental checkup and treatment on periodontal condition and general health
AAPD2024（The 16th International Conference of the Asian Academy of Preventive Dentistry）
2024/11/18
Kenta Hara
The influence of Chinese people’s eating habits on tooth coloring and its possible solutions
16th Asian Academy of Preventive Dentistry (AAPD 2024)
2024/11/18
Chika Akabane
Efficacy of Toothpaste Containing Cationic Cellulose, Calcium Salt, and Phosphate to Promote Fluoride Retention and Ion Release
JOURNAL OF DENTAL HEALTH Volume 74, Issue 4, Pages 282-289
2024/11/01
Shiori Ishii
Application of fluoride retention and release control technology to toothpaste
LDH Foundation 60th Anniversary Commemorative Seminar "Oral Future Conference"
2024/10/27
Yuki Okada
Oral Microbiota Development in the First 60 Months: A Longitudinal Study
Journal of Dental Research
2024/10/12
Kazuma Yama
Impact of chewing habits on body size in Japanese elementary school children in Kuroishi, Aomori
The 35th Annual Meeting of the Japanese Society of Mastication
2024/09/15
Hayashi Kaichi
Structural analysis of organic-inorganic complexes that achieve both fluoride retention and sustained release
62nd Annual Meeting of Japan Oil Chemists Society
2024/09/03
Hikaru Takabayashi
PCA and F+Ca+P technology to protect exposed root dentin
Check-Up Rootcare α Technical Brochure (for dental clinics)
2024/08/18
Dysbiosis of oral microbiome persists after treatment-induced remission of periodontal disease
The 97th Annual Meeting of the Japanese Society for Bacteriology
2024/08/08
Kazuma Yama
Strengthening of root dentin through self-care
5th Annual Meeting of Dental Pulp Treatment Association(Symposium lecture)
2024/07/20
Shiori Ishii
Dipotassium glycyrrhizate prevents oral dysbiosis caused by Porphyromonas gingivalis in an in vitro saliva-derived polymicrobial biofilm model
Journal of Oral Biosciences
2024/07/05
Kanta Ohara
Trends in detection of high prevalent oral bacteria and similarity to the adult microbiota during the first 60 months of life using a next-generation sequencer
The 51st NAITO CONFERENCE Microbiome in Health and Disease
2024/06/27
Kazuma Yama
Efficacy of hard gummy candy chewing in improving masticatory function in Japanese children aged 6–12 years: a clinical trial
Journal of Oral Biosciences
2024/06/20
Keishi Sato
Dipotassium glycyrrhizate and hinokitiol enhance macrophage efferocytosis by regulating recognition, uptake, and metabolism of apoptotic cells in vitro
Journal of Periodontal Research. 2024 Jun;59(3):542-551.
2024/06
Yu Yamamoto
Age-related changes in esthetic properties of human dentin
The 24th Annual Meeting of the Japanese Society of Anti-Aging Medicine
2024/05/31
Yuriko Inomata
Usefulness of dental checkups in companies ~ Oral health and presenteeism ~
Japan Society for Occupational Health Industrial Dental Health Committee Forum
2024/05/25
Yu Yamamoto
Development of the oral microbiota during the first 60 months of life
Japanese Society of Pediatric Dentistry
2024/05/16
Kazuma Yama
Application of fluoride retention and release technology to dentin for caries prevention
The 73rd General meeting of Japanese Society for Oral Health
2024/05/12
Kohei Ishii
Analysis of oral conditions and oral bacterial flora in elderly people
Japanese Society for Oral Health
2024/05/12
Takuya Inokuchi
Effects of New Mouthwash on in vitro Dental Biofilm Model
102nd International Association for Dental Research (IADR) General session & Exhibition
2024/03/16
Kim Ryunhee
Creating oral care habits that encourage behavioral changes in children ②-2 “Clinica Kid’s Toothbrush” that combines “safety” and “cleanability”.
“Togakushi” January 2015 No. 135 p. 7-8
2024/01/01
Hachisuka Ryosuke
Effect of saliva on suppressing SARS-CoV-2 and influenza virus infection by improving oral hygiene
The 2nd Annual Meeting of the Japan Saliva Care Association Excellent Poster Award
2023/11/26
Taku Iwamoto
Inhibitory Effects of Saliva on SARS-CoV-2 and Influenza Viral Infections by Improving Oral Hygiene
The 71st Annual Meeting of Japanese Association for Dental Research
2023/11/25
Yusuke Kubo
Inhibitory Effects of Saliva on SARS-CoV-2 and Influenza Viral Infections by Improving Oral Hygiene
The 15th International Conference of the Asian Academy of Preventive Dentistry
2023/11/08
Yusuke Kubo
Effects of a new mouthwash on in vitro dental biofilm model
The 15th International Conference of Asian Academy of Preventive Dentistry
2023/11/08
Kim Ryunhee
The effects of hard gummy candy chewing on oral functions in children
The 34th General Meeting of Japanese Society for Mastication Science and Health Promotion
2023/10/28
Kaichi Hayashi
Integrated analysis of the oral and intestinal microbiome and metabolome of elderly people with more than 26 original teeth: a pilot study
Frontiers in Microbiology
2023/10/12
Yuichiro Nishimoto（Metagen, Inc.）
Kazuma Yama（Lion Corporation）
Relationship between crowding and habits in elementary school children in Kuroishi City, Aomori Prefecture
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Keishi Sato
Effects of Phellodendron bark extract on periodontal pathogenic bacteria in an in vitro oral microbiome model
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Takuma Okuda
Effect of Phellodendron Bark Extract on Bacterial Composition in Oral Biofilm Model
The 65th Annual Meeting of Japanese Association for Oral Biology
2023/09/16
Kanta Ohara
Dysbiosis of Oral Microbiome Persists After Dental Treatment-Induced Remission of Periodontal Disease and Dental Caries
mSystems Vol.8, No.5
2023/09/12
Kazuma Yama
Impact of ORAL FIT, an oral frailty management service, on training continuity and oral function
The 29th Annual Meeting of the Japanese Society of Dysphagia Rehabilitation
2023/09/02
Yukihide Aoyama
Caries prevention effect of toothpaste using fluoride deposition technology
The 70th Congress ORCA 2023
2023/07/05
Chika Akabane
Effect of somatosensory stimulation in the oral cavity by tooth brushing behavior on autonomic nerve activity
Japanese Society of Psychosomatic Dentistry
2023/06/30
Asami Miyajima
Stain removal efficacy of toothbrush with elastomer-coated bristles
International Association for Dental Research(IADR)
2023/06/21
Phassamon Piyapakorn
Potassium Nitrate and Aluminum Lactate Containing Toothpaste Reduces Dentin Hypersensitivity
International Association for Dental Research(IADR)
2023/06/21
Taiki Suzuki
Validation of the usefulness of ORAL FIT, an oral frailty management service: A Pilot Study
The 34th Annual Meeting of the Japanese Society of Gerodontology
2023/06/16
Yukihide Aoyama
Plaque Removal Efficacy of New Developed IoT Toothbrush with Brushing Navigation for Children
International Association of Paediatric Dentistry
2023/06/14
Naoshi Kanamaru
Development and function of "Check-Up toothbrush standard type", a standard toothbrush for caries care
Dental magazine 185
2023/06/01
Kuniyuki Itose, Naoshi Kanamaru
Decreased Frequency of Subjective Hot Flashes in Daily Life Through Gum Massage in a Pilot Study ―An Open‒label,Self-controlled Trial―
Jpn Pharmacol Ther 2023 51（6）861 - 869
2023/06/01
Kanako Ichinose
Japanese Society of Periodontology Journal Award 2022 "Allantoin, dipotassium glycyrrhizinate, and azulene sulfonate sodium hydrate inhibit gingival inflammation induced by advanced glycation end products via antiglycation effects in vitro"
JSP Journal Award
2023/05/26
Mari Abe-Yutori
Validation of the usefulness of introducing dental checkups in the workplace
The 66th Spring Meeting of the Japanese Society of Periodontology
2023/05/26
Yu Yamamoto
Effect of encouragement to see a dentist in occupational dental checkups on periodontal disease and systemic health
The 66th Spring Meeting of the Japanese Society of Periodontology
2023/05/26
Kimura Mitsuo
Safety and plaque removal efficacy of Kid’s toothbrush with bendable/unbreakable neck
2023 Central Interntional Dental Exhibition
2023/05/24
Ryosuke Hachisuka
Building a technical foundation for the development of oral care products
The Japan Society for Analytical Chemistry
2023/05/20
Narumi Fujii
Comparison of oral microbiota before and after dental treatment in healthy and carious patients
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Takuya Inokuchi
The relationship between the introduction of dental checkups in the workplace and oral health and productivity
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Yu Yamamoto
Comparison of oral microbiota between oral healthy subjects and periodontal disease patients before and after dental treatment
The 72nd General meeting of Japanese Society for Oral Health
2023/05/19
Kazuma Yama
Effects of chewing hard gummies on oral function in elementary school children
The 61st Annual Conference of the Japanese Society of Pediatric Dentistry
2023/05/18
Keishi Sato
Fluoride and Caries prevention
Tokyo Medical and Dental University
2023/03/15
Chika Akabane
Research on an EIS-type biosensor that detects cortisol in saliva
The 70th JSAP Spring meeting 2023
2023/03/15
Yuki Maruyama
An in vitro study of the effects of Phellodendron bark extract and berberine chloride on periodontal pathogenic bacteria in the oral microbiome
Journal of Oral Biosciences Volume 65, Issue 1, March 2023, Pages 72-79
2023/03/02
Takuma Okuda
Oxidative stress inhibits endotoxin tolerance and may affect periodontitis
Journal of Dental Research 102(3):331-339
2023/03/02
Tsuguno Yamaguchi
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water
the 1st Annual Meeting of the Japan Saliva Care Research Association
2022/11/27
Yuki Maruyama
Inhibitory effects of toothpaste ingredients on novel coronavirus (SARS-CoV-2) infection in vitro
the 1st Annual Meeting of the Japan Saliva Care Research Association
2022/11/27
Taku Iwamoto
Nanostructural analysis and age-related changes of apatite particles in human dentin
The 44th Annual Meeting of the Japanese Society of Biomaterials
2022/11/21-11/22
Chika Akabane
Age-related changes in mechanical and esthetics properties in human dentin
The 157th Meeting of the Japanese Society of Conservative Dentistry
2022/11/10-11/11
Yuriko Inomata
An in vitro study of the effect of berberine chloride on periodontal pathogenic bacteria in the oral microbiome
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Daisuke Watai
Comparison of oral microbiome profiles in 18-month-old infants and their parents
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Ryutaro Jo
Trends in detection of high prevalent oral bacteria during the first 60 months of life using a next-generation sequencer
The 9th International Human Microbiome Consortium (IHMC) Congress 2022
2022/11/8-11/10
Kazuma Yama
Establishment of oral metabolome profiling method using mouth-rinsed water by capillary electrophoresis–mass spectrometry
The 42nd Symposium on Capillary Electrophoresis (SCE2022)
2022/10/26-10/28
Yuki Maruyama
Relationship between oral care behavior and cold morbidity in workers
The 81st Annual Meeting of Japanese Society of Public Health
2022/10/7-10/9
Ryutaro Jo
evelopment of EIS biosensors for rapid cortisol determination in saliva
2022 International Conference on Solid State Devices and Materials (SSDM2022)
2022/9/26-9/29
Yuki Maruyama
Rapid measurement of EIS biosensors for detecting cortisol concentration in saliva
The 83rd JSAP Autumn meeting 2022
2022/9/20-9/23
Yuki Maruyama
Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (2): Analysis of inter- and intra-day variation of fat-soluble metabolites by liquid chromatography-mass spectrometry
The 16th Metabolome Symposium
2022/9/14-9/16
Narumi Fujii
Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (1): Analysis of inter- and intra-day variation of water-soluble metabolites by capillary electrophoresis–mass spectrometry
The 16th Metabolome Symposium
2022/9/14-9/16
Yuki Maruyama
Antiglycation of periodontitis preventive active ingredients in self-care oral hygiene products
The 65th Autumn Meeting of the Japanese Society of Periodontology
2022/9/2-9/3
Tsuguno Yamaguchi
Phellodendron Bark Extract inhibits osteoclastogenesis by regulation of Nfatc1 gene expression
The 14th Asian Pacific Society of Periodontology Meeting 2022
2022/8/29-8/30
Yu Yamamoto
An in vitro study of effects of Phellodendron Bark Extract on the periodontal pathogenic bacteria in the oral microbiome.
The 14th Asian Pacific Society of Periodontology Meeting 2022
2022/8/29-8/30
Takuma Okuda
The effect of the flavor of children's toothpaste on the tooth-brushing behavior of pre-school children
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Tohru Ohki
The survey of taste sensitivity decrease in healthy subjects:
Relationship between age, taste sensitivity and other factors
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Anna Tsuge
The 23rd (2021) Oils and Fats Technical Paper Excellence Award 「The inhibitory effects of toothpaste and mouthwash ingredients on the cellular infection process of SARS-CoV-2 infection in vitro」
Oil & Fat Industry Kaikan Award
2022/8/22
Taku Iwamoto
Survey of taste sensitivity decrease in healthy subjects: Study on tastesensitivity decrease and the affecting factors in the 20s
The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell
2022/8/22-8/24
Satoshi Tomeoka
Plaque removal efficacy of bendable/unbreakable safety toothbrush for infant
The 4th International Symposium on Oral Care
2022/7/11
Ryosuke Hachisuka
Comparison of Healthy Versus before/after-Dental Treatment Oral Microbiome
International Association for Dental Research(IADR)
2022/6/20-6/25
Takuya Inokuchi
Effectiveness of the new oral care device for children.
International Association for Dental Research(IADR)
2022/6/20-6/25
Tomonari Kanasugi
Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro
International Association for Dental Research(IADR)
2022/6/20-6/25
Taku Iwamoto
Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro
International Association for Dental Research(IADR)
2022/6/20-6/25
Riho Makino
Virucidal activity of oral care products against enveloped viruses
International Association for Dental Research(IADR)
2022/6/20-6/25
Ryosuke Komatsu
Comparison of Healthy Versus before/after-Dental Treatment Oral Metabolome Profiles
International Association for Dental Research(IADR)
2022/6/20-6/25
Narumi Fujii
Usefulness of Porcine Gingiva for Penetration Tests of Hydrophobic Ingredients
International Association for Dental Research(IADR)
2022/6/20-6/25
Aya Ohkuni
Science behind toothbrush
International Association for Dental Research(IADR)
2022/6/20-6/25
Reona Noda
Plaque removal efficacy of kids’ toothbrush with easily bent neck
International Association for Dental Research(IADR)
2022/6/20-6/25
Sakiho Hayashida
Age-related deterioration of the human dentin
International Association for Dental Research(IADR)
2022/6/20-6/25
Chika Akabane
Study of toothpaste applying fluoride retention and release technology
The 156th Meeting of the Japanese Society of Conservative Dentistry
2022/6/16-7/6
Masashi Fujiki
Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro
European Federation of Periodontology 10th
2022/6/15-6/18
Kota Tsutsumi
Toothpaste technology that cares for the supportive tissue of teeth
Dental Magazine 181 SUMMER
2022/6/1
Yu Yamamoto
Examination of fluoride retention technology of toothpaste using fluoride retention and release technology in the oral cavity
The 71st General meeting of Japanese Society for Oral Health
2022/5/13-5/27
Mari Imazaki
Fluoride retention and release technology contributing to self-care of dental caries prevention
The 71st General meeting of Japanese Society for Oral Health
2022/5/13-5/27
Mari Imazaki
Development of EIS type biosensor to detect cortisol in saliva
The 69th JSAP Spring meeting 2022
2022/3/22-3/26
Yuki Maruyama
The relationship between malocclusion and habits in elementary school children in Kuroishi city, Aomori prefecture
The 92nd Annual Meeting of the Japanese Society for Hygiene
2022/3/21-3/23
Keishi Sato
Fluoride retention and release technology contributing to self-care of dental caries prevention
The Japan Dental Show 2021
2022/3/4-3/6
Mari Imazaki
Fluoride retention and release technology contributing to self-care of dental caries prevention
Dental Magazine 180 SPRING
2022/3/1
Ryota Hashimoto
About the development and function of the nursing care toothbrush "Elac Toothbrush 620" that facilitates oral care for care recipients
Dental Magazine 180 SPRING
2022/3/1
Aya Miyazawa, Naoshi Kanamaru
Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water
Scientific Reports 12, Article number: 689 (2022)
2022/1/13
Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)
1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,
Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism
The 80th Annual Meeting of Japanese Society of Public Health
2021/12/21-12/23
Yukari Sekine
A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey
BMC Oral Health
2021/12/15
Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto 1), Yasushi Koike 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)
1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,
Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity
The 155th Meeting of the Japanese Society of Conservative Dentistry
2021/10/28-11/10
Masakazu Ono
Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ～The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.
The 36th Conference of the Japanese Society of Pediatric Dentistry
2021/10/17-10/23
Ryosuke Hachisuka
Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation
The 64th Autumn Meeting of the Japanese Society of Periodontology
2021/10/15-10/16
Yu Yamamoto
Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Kazuma Yama
Inhibitory effects of toothpaste and mouthwash ingredients on SARS CoV 2 priming protease TMPRSS2
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Riho Makino
Inhibitory effects of toothpaste and mouthwash ingredients on
the interaction between S-protein of SARS-CoV-2 and ACE2
The 63rd Annual Meeting of Japanese Association for Oral Biology
2021/10/9-10/11
Mari Yutori
The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Taku Iwamoto
The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Yukihide Aoyama
Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Yasushi Koike
Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”
The 14th International Conference of Asian Academy of Preventive Dentistry
2021/10/1-10/3
Kota Tsutsumi
The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro
PLOS ONE 2021; 16(9): e0257705.
2021/9/17
Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1), Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)
1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function
3)Division of Environmental Pathology, Department of Oral
Science, Kanagawa Dental University
Basic study on staining and removal of dentin by various beverages
The 70th General meeting of Japanese Society for Oral Health
2021/5/27-6/10
Ayaka Iwasaki
Material design of intelligent plastic products with sound generation function due to snap-through buckling
2021 Eng. Res. Express 3 015006
2021/5/11
Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)
1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,
Survey on oral care habits and halitosis among general community residents
The 18th Annual Meeting of the Japanese Society of Oral Care
2021/4/17-4/18
Chiyoko Uchiyama
Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2
The 101st CSJ Annual Meeting (2021）
2021/3/19-3/21
Mari Yutori
The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection
The 101st CSJ Annual Meeting (2021）
2021/3/19-3/21
Riho Makino
The effect of aging on the nanostructure of murine alveolar bone and dentin
Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)
2021/3/11
Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)
1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan