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Our Research: Basic Technology Research

Environment and Human Safety

Lion takes its responsibility for providing customers with peace of mind through safety evaluations based on scientific evidence extremely seriously. We conduct wide-ranging safety assessments of the effects of Lion products and their raw materials on people and the environment, applying technologies related to living organisms, including those in the fields of molecular biology and physiology. These assessments ensure that customers can use Lion products with confidence. In addition to performing evaluations, Lion is involved in the development of safety assessment technologies, such as alternatives to animal testing.

The importance of safety evaluation and confirmation is the same worldwide. Lion takes a global perspective as it aggressively gathers and analyzes safety data from in and outside Japan and uses such data in actual safety evaluations. At the same time, Lion actively participates in various industry associations, cooperating to help solve problems.

R&D Case Study—Environment and Human Safety

Research Accomplishment—Environment and Human Safety

2022

  • Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.

    Journal of Applied Toxicology 18 January 2022
    2022/1/18
    Yusuke Yamamoto1), Masaharu Fujita1), Shinichi Watanabe2),Hiroaki Yamaga2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kazuya Takeuchi5), Kohei Kamiya5), Tsuyoshi Kawakami6), Kohichi Kojima7), Takashi Sozu8), Hajime Kojima9), Toshihiko Kasahara1), Atsushi Ono10)
    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation,, 3) Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University

2021

  • The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.

    Journal of Applied Toxicology 2022 Feb;42(2):318-333.
    2021/12/1
    Masaharu Fujita1), Yusuke Yamamoto1), Sayaka Wanibuchi1), Shinichi Watanabe2), Hiroaki Yamaga2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kazuya Takeuchi5), Kohei Kamiya5), Tsuyoshi Kawakami6), Kohichi Kojima7), Takashi Sozu8), Hajime Kojima9), Toshihiko Kasahara1), Atsushi Ono10)
    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University

  • Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances：Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system

    The Japanese Society for Alternatives to Animal Experiments
    2021/11/11-11/13
    Hiroaki Yamaga (Joint research with Fujifilm)

  • Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing

    The Japanese Society for Alternatives to Animal Experiments
    2021/11/11-11/13
    Junko Ueno

  • The Japanese Society for Alternatives to Animal Experiments Best Presentation Award
    A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The Japanese Society for Alternatives to Animal Experiments 
    2021/11/11-11/13
    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society of Toxicology Excellent Research Presentation Award
    Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation

    The Japanese Society of Toxicology
    2021/7/7-7/9
    Seiya Aizawa (Joint research with Kao Corporation and Sunstar Corporation)

  • Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances

    Journal of Applied Toxicology
    2021/2/26
    Hiroaki Yamaga1),Shinichi Watanabe1), Masaharu Fujita2), Yusuke Yamamoto2), Toshihiko Kasahara2),Shinsuke Kataoka1)
    1) Safety Science Research Laboratories, Lion Corporation, 2) Safety Evaluation Center, Fujifilm Corporation

2020

  • Introduction of EpiSensA, an alternative method for skin sensitization test using 3D human epidermis model, for evaluation of poorly water-soluble substances

    The Japanese Society for Alternatives to Animal Experiments
    2020/11/12-11/13
    Junko Ueno

  • Case studies of microbial problems in the manufacturing genba of cosmetics and personal care products

    Fragrance journal : Research & development for cosmetics, toiletries & allied industries　 48(5), 53-64, 2020-05
    2020/5/1
    Masahiko Otani

  • New approach to evaluation and classification of irritation intensity of oral care ingredients using a three-dimensional human buccal mucosal model.

    Society of Toxicology Annual Meeting
    2020/3/15-19
    Joint research with Kao Corporation and Sunstar Corporation

  • Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

    Jounal of Applied Toxicology, 2020;40:843-854
    2020/2/12
    Miyuki Akimoto1), Yusuke Yamamoto1), Shinichi Watanabe2), Hiroaki Yamaga2), Kousuke Yoshida2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), | Kei Kusakari5), Kohei Kamiya5), Kohichi Kojima6), Tsuyoshi Kawakami7), Hajime Kojima8), Atsushi Ono9), Toshihiko Kasahara1), Masaharu Fujita1)
    1) Fujifilm Corporation, Safety Evaluation Center, 2) Lion Corporation, 3) Mitsui Chemicals, Inc. Chemical Safety Department, 4) Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory, 5) Nissan Chemical Corporation, Biological Research Laboratories, 6) Food and Drug Safety Center, Hatano Research Institute, 7) Division of Environmental Chemistry, National Institute of Health Sciences, 8) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 9) Okayama University

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