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Research Accomplishments

Oral Technology

  • Stain removal efficacy of toothbrush with elastomer-coated bristles

    International Association for Dental Research(IADR)

    2023/06/21

    Phassamon Piyapakorn

  • Potassium Nitrate and Aluminum Lactate Containing Toothpaste Reduces Dentin Hypersensitivity

    International Association for Dental Research(IADR)

    2023/06/21

    Taiki Suzuki

  • Plaque Removal Efficacy of New Developed IoT Toothbrush with Brushing Navigation for Children

    International Association of Paediatric Dentistry

    2023/06/14

    Naoshi Kanamaru

  • Acceleration of toothpaste development using Bayesian optimization method

    The 37th Annual Conference of the Japanese Society for Artificial

    2023/06/06

    Eisuke Inagaki

  • Development and function of "Check-Up toothbrush standard type", a standard toothbrush for caries care

    Dental magazine 185

    2023/06/01

    Kuniyuki Itose, Naoshi Kanamaru

  • Validation of the usefulness of introducing dental checkups in the workplace

    The 66th Spring Meeting of the Japanese Society of Periodontology

    2023/05/26

    Yu Yamamoto

  • Effect of encouragement to see a dentist in occupational dental checkups on periodontal disease and systemic health

    The 66th Spring Meeting of the Japanese Society of Periodontology

    2023/05/26

    Kimura Mitsuo

  • Safety and plaque removal efficacy of Kid’s toothbrush with bendable/unbreakable neck

    2023 Central Interntional Dental Exhibition

    2023/05/24

    Ryosuke Hachisuka

  • Building a technical foundation for the development of oral care products

    The Japan Society for Analytical Chemistry

    2023/05/20

    Narumi Fujii

  • Comparison of oral microbiota before and after dental treatment in healthy and carious patients

    The 72nd General meeting of Japanese Society for Oral Health

    2023/05/19

    Takuya Inokuchi

  • The relationship between the introduction of dental checkups in the workplace and oral health and productivity

    The 72nd General meeting of Japanese Society for Oral Health

    2023/05/19

    Yu Yamamoto

  • Effects of chewing hard gummies on oral function in elementary school children

    The 61st Annual Conference of the Japanese Society of Pediatric Dentistry

    2023/05/18

    Keishi Sato

  • Fluoride and Caries prevention

    Tokyo Medical and Dental University

    2023/03/15

    Chika Akabane

  • Research on an EIS-type biosensor that detects cortisol in saliva

    The 70th JSAP Spring meeting 2023

    2023/03/15

    Yuki Maruyama

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    the 1st Annual Meeting of the Japan Saliva Care Research Association

    2022/11/27

    Yuki Maruyama

  • Inhibitory effects of toothpaste ingredients on novel coronavirus (SARS-CoV-2) infection in vitro

    the 1st Annual Meeting of the Japan Saliva Care Research Association

    2022/11/27

    Taku Iwamoto

  • Nanostructural analysis and age-related changes of apatite particles in human dentin

    The 44th Annual Meeting of the Japanese Society of Biomaterials

    2022/11/21-11/22

    Chika Akabane

  • Age-related changes in mechanical and esthetics properties in human dentin

    The 157th Meeting of the Japanese Society of Conservative Dentistry

    2022/11/10-11/11

    Yuriko Inomata

  • An in vitro study of the effect of berberine chloride on periodontal pathogenic bacteria in the oral microbiome

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Daisuke Watai

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Ryutaro Jo

  • Trends in detection of high prevalent oral bacteria during the first 60 months of life using a next-generation sequencer

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Kazuma Yama

  • Establishment of oral metabolome profiling method using mouth-rinsed water by capillary electrophoresis–mass spectrometry

    The 42nd Symposium on Capillary Electrophoresis (SCE2022)

    2022/10/26-10/28

    Yuki Maruyama

  • Relationship between oral care behavior and cold morbidity in workers

    The 81st Annual Meeting of Japanese Society of Public Health

    2022/10/7-10/9

    Ryutaro Jo

  • evelopment of EIS biosensors for rapid cortisol determination in saliva

    2022 International Conference on Solid State Devices and Materials (SSDM2022)

    2022/9/26-9/29

    Yuki Maruyama

  • Rapid measurement of EIS biosensors for detecting cortisol concentration in saliva

    The 83rd JSAP Autumn meeting 2022

    2022/9/20-9/23

    Yuki Maruyama

  • Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (2): Analysis of inter- and intra-day variation of fat-soluble metabolites by liquid chromatography-mass spectrometry

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Narumi Fujii

  • Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (1): Analysis of inter- and intra-day variation of water-soluble metabolites by capillary electrophoresis–mass spectrometry

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Yuki Maruyama

  • Antiglycation of periodontitis preventive active ingredients in self-care oral hygiene products

    The 65th Autumn Meeting of the Japanese Society of Periodontology

    2022/9/2-9/3

    Tsuguno Yamaguchi

  • Phellodendron Bark Extract inhibits osteoclastogenesis by regulation of Nfatc1 gene expression

    The 14th Asian Pacific Society of Periodontology Meeting 2022

    2022/8/29-8/30

    Yu Yamamoto

  • An in vitro study of effects of Phellodendron Bark Extract on the periodontal pathogenic bacteria in the oral microbiome.

    The 14th Asian Pacific Society of Periodontology Meeting 2022

    2022/8/29-8/30

    Takuma Okuda

  • The effect of the flavor of children's toothpaste on the tooth-brushing behavior of pre-school children

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Tohru Ohki

  • The survey of taste sensitivity decrease in healthy subjects:
    Relationship between age, taste sensitivity and other factors

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Anna Tsuge

  • The 23rd (2021) Oils and Fats Technical Paper Excellence Award 「The inhibitory effects of toothpaste and mouthwash ingredients on the cellular infection process of SARS-CoV-2 infection in vitro」

    Oil & Fat Industry Kaikan Award

    2022/8/22

    Taku Iwamoto

  • Survey of taste sensitivity decrease in healthy subjects: Study on tastesensitivity decrease and the affecting factors in the 20s

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Satoshi Tomeoka

  • Plaque removal efficacy of bendable/unbreakable safety toothbrush for infant

    The 4th International Symposium on Oral Care

    2022/7/11

    Ryosuke Hachisuka

  • Comparison of Healthy Versus before/after-Dental Treatment Oral Microbiome

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Takuya Inokuchi

  • Effectiveness of the new oral care device for children.

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Tomonari Kanasugi

  • Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Taku Iwamoto

  • Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Riho Makino

  • Virucidal activity of oral care products against enveloped viruses

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Ryosuke Komatsu

  • Comparison of Healthy Versus before/after-Dental Treatment Oral Metabolome Profiles

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Narumi Fujii

  • Usefulness of Porcine Gingiva for Penetration Tests of Hydrophobic Ingredients

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Aya Ohkuni

  • Science behind toothbrush

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Reona Noda

  • Plaque removal efficacy of kids’ toothbrush with easily bent neck

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Sakiho Hayashida

  • Age-related deterioration of the human dentin

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Chika Akabane

  • Study of toothpaste applying fluoride retention and release technology

    The 156th Meeting of the Japanese Society of Conservative Dentistry

    2022/6/16-7/6

    Masashi Fujiki

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro

    European Federation of Periodontology 10th

    2022/6/15-6/18

    Kota Tsutsumi

  • Toothpaste technology that cares for the supportive tissue of teeth

    Dental Magazine 181 SUMMER

    2022/6/1

    Yu Yamamoto

  • Examination of fluoride retention technology of toothpaste using fluoride retention and release technology in the oral cavity

    The 71st General meeting of Japanese Society for Oral Health

    2022/5/13-5/27

    Mari Imazaki

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    The 71st General meeting of Japanese Society for Oral Health

    2022/5/13-5/27

    Mari Imazaki

  • Development of EIS type biosensor to detect cortisol in saliva

    The 69th JSAP Spring meeting 2022

    2022/3/22-3/26

    Yuki Maruyama

  • The relationship between malocclusion and habits in elementary school children in Kuroishi city, Aomori prefecture

    The 92nd Annual Meeting of the Japanese Society for Hygiene

    2022/3/21-3/23

    Keishi Sato

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    The Japan Dental Show 2021

    2022/3/4-3/6

    Mari Imazaki

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    Dental Magazine 180 SPRING

    2022/3/1

    Ryota Hashimoto

  • About the development and function of the nursing care toothbrush "Elac Toothbrush 620" that facilitates oral care for care recipients

    Dental Magazine 180 SPRING

    2022/3/1

    Aya Miyazawa, Naoshi Kanamaru

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports 12, Article number: 689 (2022)

    2022/1/13

    Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)

    1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    The 80th Annual Meeting of Japanese Society of Public Health

    2021/12/21-12/23

    Yukari Sekine

  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health

    2021/12/15

    Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto 1), Yasushi Koike 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)

    1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,

  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The 155th Meeting of the Japanese Society of Conservative Dentistry

    2021/10/28-11/10

    Masakazu Ono

  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    The 36th Conference of the Japanese Society of Pediatric Dentistry

    2021/10/17-10/23

    Ryosuke Hachisuka

  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64th Autumn Meeting of the Japanese Society of Periodontology

    2021/10/15-10/16

    Yu Yamamoto

  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Kazuma Yama

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS CoV 2 priming protease TMPRSS2

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Riho Makino

  • Inhibitory effects of toothpaste and mouthwash ingredients on
    the interaction between S-protein of SARS-CoV-2 and ACE2

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Mari Yutori

  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Taku Iwamoto

  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yukihide Aoyama

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yasushi Koike

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Kota Tsutsumi

  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE 2021; 16(9): e0257705.

    2021/9/17

    Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1), Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)

    1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function
    3)Division of Environmental Pathology, Department of Oral
    Science, Kanagawa Dental University

  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    2021 Eng. Res. Express 3 015006

    2021/5/11

    Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,

  • Survey on oral care habits and halitosis among general community residents

    The 18th Annual Meeting of the Japanese Society of Oral Care

    2021/4/17-4/18

    Chiyoko Uchiyama

  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The 101st CSJ Annual Meeting (2021)

    2021/3/19-3/21

    Mari Yutori

  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The 101st CSJ Annual Meeting (2021)

    2021/3/19-3/21

    Riho Makino

  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)

    2021/3/11

    Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports 11, Article number: 861 (2021)

    2020/1/13

    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara,Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki

    Research and Development Headquarters, Lion Corporation,

  • Basic study on staining and removal of dentin by various beverages

    The 70th General meeting of Japanese Society for Oral Health

    2021/5/27-6/10

    Ayaka Iwasaki

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology

    2020/12/1

    Reona Noda,Shizuka Kawasaki,Ryosuke Hachisuka

  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    The 79th Annual Meeting of Japanese Society of Public Health

    2020/10/20-10/22

    Koichiro Hayashi

  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    The 31st General Scientific Meeting of Japan Academy of Esthetic Dentistry

    202010/3-10/4

    Ryota Hashimoto

  • Development of "RePERO", an application to support breath care

    The 71st Divisional Meeting of Division of Colloid and Surface Chemistry

    2020/9/13-9/16

    Kengo Oka

  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration

    2020/9/13

    Ken-ichiro Shibasaki

  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science

    2020/7/21-7/24

    Yuya Kimoto

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The 152nd Meeting of the Japanese Society of Conservative Dentistry

    2020/6/11-6/12

    Rika Oda

  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    The 63rd Spring Meeting of the Japanese Society of Periodontology

    2020/5/29-5/30

    Kenji Egashira

  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    The 58th Annual Conference of the Japanese Society of Pediatric Dentistry

    2020/5/20-5/21

    Mai Satake

  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research(IADR)

    2020/3/18-3/21

    Tsuguno Yamaguchi

  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University

    2020/3/11

    Eiji Nishinaga

  • Inhibitory effects of pyrrolidone carboxylic acid on dentin demineralization and collagen degradation

    THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY(Jpn J Conserv Dent)

    2020/1/7

    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

  • Japan Institute of invention and innovation
    No.:6591988(Toothbrushes that can limit damage to the user's mouth)

    Japan Institute of Invention and Innovation

    2020/11/12

    Ryosuke Haschisuka

  • Asian Pacific Society of Periodontology Meeting 2019 Poster presentation competition Lab research 1st Prize
    「Effects of pyrrolidone carboxylic acid on dentin collagen degradation and demineralization」

    The 13th Asian Pacific Society of Periodontology Meeting 2019

    2019/9/28-9/29

    Shiori Ishii

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports 9, Article number: 16124 (2019)

    2019/11/6

    Ryutaro Jo 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Kazuma Yama 1), Yuto Aita 1), Yuko Ichiba 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1), Takashi Kumagai 3), TakujiYamada 2),5),6) Shinji Fukuda2),4),6),7),8)

    1)Research and Development Headquarters, 2)Metabologenomics, Inc.,3)Hiyoshi Oral Health Clinics. ,4)Institute for Advanced Biosciences, Keio University,5)Department of Life Science and Technology, Tokyo Institute of Technology, 6)PRESTO, Japan Science and Technology Agency,8)Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8)Transborder Medical Research Center, University of Tsukuba,

  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics 2019 Annual Meeting

    2019/10/15-10/19

    Satoshi Morishita

  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research volume 26, Article number: 246 (2019)

    2019/9/12

    Ryosuke Hachisuka 1)2), Toshiaki Kobayashi 3), Masayuki Yamaguchi 2)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology,2)Research & Development Headquarters, Lion Corporation, 3)The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)

  • A New Method to Speculate Halitosis Level Using Machine Learning

    International Association for Dental Research (IADR)

    2019/6/19-6/22

    Chiaki Michibayashi

  • Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts―in vitro study

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • The Journal of Japanese Society of Periodontology, 2019 Journal Award
    「Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study」

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports 9, Article number: 3559 (2019)

    2019/3/5

    Takuya Hayakawa 1), Shizuka Kawasaki 1), Yutaka Hirayama 1),Takuya Tsutsui 1), Eiji Sugiyama 2), Kiyo Adachi 1), Ryo Kon 1), Makoto Suematsu 2), Yuki Sugiura 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biochemistry, Keio University School of Medicine,

  • Importance of approaches to the host's defense mechanism in the prevention of periodontal disease and the effects of vitamin E

    The 149th Meeting of the Japanese Society of Conservative Dentistry

    2018/11/1

    Mari Yutori

  • Effects of copper gluconate on oral malodor

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Masato Takahashi

  • The wound healing effect of vitamin-E on human gingival fibroblasts

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Mari Yutori

  • Evaluation of vitamin-E permeability using human three-dimensional culture epidermis model

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Kazuaki Kojima

  • Technologies supporting oral care products

    The 60th Annual Meeting of Japanese Association for Oral Biology

    2018/9/5-9/7

    Mari Yutori

  • Effects of sodium polyacrylate on periodontal disease biofilm in vitro

    The 61st Spring Meeting of the Japanese Society of Periodontology

    2018/6/1-6/2

    Yusuke Kawanobe

  • THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR
    Excellent scientific papers First Class
    「Decomposition and removal of dental model plaque by using toothpaste containing dextranase」

    THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR

    2018/4/12

    Yuko Aoki 1), Gotaro Izumi 1), Yasuo Nomura 1), Ken-ichiro Shibasaki 1), 刘婧 2), 李德豹 2), 安丰宝 2) ,郑苏江 3)

    1)Lion Corporation
    2)獅王日用化工(青島)有限公司
    3)中国科学院理化技術研究所

  • Analysis of oral microbiome formation process in infancy

    The 91st Anuual Meeting of Japanese Society for Bacteriology

    2018/3/27-3/29

    Ryutaro Jo

Interface Technology

  • Fractal gel network structure comprising chlorohydroxyaluminum nanoparticles having antiperspirant function

    The 73rd Divisional Meeting of Division of Colloid and Surface Chemistry

    2022/9/20-9/22

    Sachiko Masaoka

  • 2021 (56th) Japan Oil Chemists' Journal of Oleo Science Editors’Award "Synergic Effects of Surfactant and Chelating Agent on Stubborn Keratin Grime for Easy Cleaning"

    J. Oleo Sci. 70, (12) 1769-1776 (2021)

    2021/11/9

    Shinya Sudo, Yosuke Watanabe, Kazuya Inomata, Ryo Hyodo, Atsushi Naito

    Research and Development Headquarters, Lion Corporation

  • 2021 (56th) Japan Oil Chemists' Society Industrial Technology Award "Developing a Method to Remove Stubborn Bathtub Keratin Grime and Application to the Bath Cleaner that can reduce the burden of daily cleaning"

    Oleo Science 2022 Volume22 Issue6 Pages 254-255

    2021/11/9

    Shinya Sudo, Ryo Hyodo, Yosuke Watanabe, Atsushi Naito

    Research and Development Headquarters, Lion Corporation

  • Structural Analysis of Nanoparticles and Gel Networks Formed by Chlorohydroxyaluminum by Small- and Wide-Angle X-ray Scattering

    The 72nd Divisional Meeting of Division of Colloid and Surface Chemistry

    2021/9/15-9/17

    Sachiko Masaoka

  • Enhancement of Virus Inactivation of Cationic Surfactants by Sulfate Ions

    The 60th Annual Meeting of the Japan Oil Chemists' Society

    2021/9/6-9/11

    Rei Saito

  • Dispersion stabilization of fragrance capsules in fabric softeners - Viscoelasticity control in vesicle systems based on depletion aggregation

    The 60th Annual Meeting of the Japan Oil Chemists' Society

    2021/9/6-9/11

    Asami Miyajima

  • Synergistic effects of surfactants and chelating agents on tightly adherent keratin for simple cleaning

    The 60th Annual Meeting of the Japan Oil Chemists' Society

    2021/9/6-9/11

    Shinya Sudo

  • Permeation Behavior of Liposoluble Substances Solubilized in Bile Salts/Phospholipid Mixture Micelles through Biological Membrane Models

    The 60th Annual Meeting of the Japan Oil Chemists' Society

    2021/9/6-9/11

    Sara Isurugi

  • Foundation, Oil and Fat Industury Kaikan, 64th Excellent article award in Oil and Fat technology
    「Effect of Mineral Oil Addition on Membrane Stability of Polar Lipids Derived from Mibum」

    Oil & Fat Industry Kaikan Award 

    Masataka Yoshida,Atushi Sato

  • The Effect of Bile Salts/Phospholipid Mixed Solutions
    on the Morphology of Giant Unilamellar Vesicles

    The 59th Annual Meeting of the Japan Oil Chemists' Society

    2020/11/2-11/7

    Miyuki Miyake

  • Purpose of establishment and activities of the "Social Health Strategy Research Institute" aiming to improve social health and realize a sustainable symbiotic society

    The 71st Divisional Meeting of Division of Colloid and Surface Chemistry

    2020/9/14-9/16

    Miyuki Miyake

  • Visualization of Fabric Fluffiness and Dryness
    ―Evaluation of Laundry Detergents Using X-ray Computer Tomography ―

    Rigaku Jounal

    2020/5/1

    Yukari Sekine

  • 51st Oil Industry Papers Honorable Mention (Japanese only)
    “Creating new value in the fats and oils industry through a new alliance with the pharmaceutical industry and eliminating health disparities”

    Oil & Fat Industry Kaikan

    Yasushi Kudo

  • Micellar Effects on the Hydrolysis Reaction of an Anionic Surfactant in Aqueous Solution and Measurements of Adsorbed Proton on the Micellar Surface.

    The 70th Divisional Meeting of Division of Colloid and Surface Chemistry

    2019/11/3-11/4

    Miyuki Miyake

  • Developing New Methyl Ester Ethoxylate with Long Alkyl Chain Length

    The 58th Annual Meeting of the Japan Oil Chemists' Society

    2019/9/24-9/26

    Akinori Joko

  • Development of novel eye drops by applying the permeability of vitamin nanoemulsions into corneal cell

    The 71st Society for Biotechnology, Japan/Annual Meeting 2019

    2019/9/16-9/18

    Miyuki Miyake

  • Developing New Methyl Ester Ethoxylate Derived from C18 Fraction of Palm Oil for Liquid Laundry Detergent

    CESIO 11th World Surfactant Congress (2019)

    2019/6/3-6/5

    Sho Tsujimura

  • Foundation, Oil and Fat Industury Kaikan, 63th Excellent article award in Oil and Fat technology
    「Structural Viscosity Induced by Depletion Effect in Stable Vesicle Dispersion」

    Oil & Fat Industry Kaikan Award 

    Asami Miyajima , Ryo Inoue, Erika Onishi, Miyuki Miyake, and Ryo Hyodo

    Research and Development Headquarters, Lion Corporation

  • Structural Viscosity Induced by Depletion Effect in Stable Vesicle Dispersion

    J. Oleo Sci. 68, (9) 837-845 (2019)

    2019/5/25

    Asami Miyajima , Ryo Inoue, Erika Onishi, Miyuki Miyake, and Ryo Hyodo

    Research and Development Headquarters, Lion Corporation

  • Homogenized Bimetallic Catalysts from Metal-Organic Framework Alloys

    Chemistry of Material. 2019, 31, 11, 4205–4212

    2019/3/22

    Jet-Sing M. Lee 1), Yu-ichi Fujiwara 2), Susumu Kitagawa 1), Satoshi Horike 1),3),4),5)

    1)Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, 2) Research & Development Headquarters, LION Corporation, 3)AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory (ChEM-OIL), Kyoto University, 4)Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 5) Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology,

  • The 7th Young Researcher Encouragement Award
    「Application of environmentally friendly surfactant MES to liquid detergents」

    Japan Oil Chemists' Society Kanto Branch

    Atsunori Morigaki

  • Foundation, Oil and Fat Industury Kaikan, 63th Excellent article award in Oil and Fat technology
    「Structural Viscosity Induced by Depletion Effect in Stable Vesicle Dispersion」

    Oil & Fat Industry Kaikan Award

    Asami Miyajima, Ryo Inoue, Miyuki Miyake

  • Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling

    Applied Microbiology and Biotechnology volume 102, pages 8909-8920 (2018)

    2018/8/10

    Yuki Maruyama 1), Yoshihiro Toya 2), Hiroshi Kurokawa 1), Yuka Fukano 1), Atsushi Sato 1), Hiroyasu Umemura 1), Kaoru Yamada 1), Hideaki Iwasaki 1), Norio Tobori 1), Hiroshi Shimizu 2)

    1)Research and Development Headquarters, Lion Corporation, 2)Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University

  • Construction of Evaluation Model of Tear Film Lipid Layer Stability, and Research of Influence of Endogenous Ingredients in Meibum on the Stability

    C & I commun : colloid & interface communication : newsletter from DCSC 43, 1, 13-16 2018.3

    Masataka Yoshida

  • Japan Oil Chemist's Society, 52th Progress Award
    「Structural Analysis in solutions - Innovation for surfactant science using scattering techniques -」

    The 52nd Annual Meeting of the Japan Oil Chemists' Society

    Taku Ogura

    Research and Development Headquarters, Lion Corporation

Aroma Technology

  • Analysis of Brain Activity Related to Fragrance Preference of Fabric Softener for Clothes

    The 55th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2021/10/19-10/21

    Kai Saito

  • Extraction and Analysis Method of Fragrance in High Concentration Surfactant

    The 64th TEAC

    2020/10/24-10/26

    Keita Sawada

  • JAPAN RESEARCH INSTITUTE OF MATERIAL TECHNOLOGY, Gold Poster Award 「Analysis of solubilization of perfume molecules in micelles using small-angle X-ray scattering(SAXS)」

    JAPAN RESEARCH INSTITUTE OF MATERIAL TECHNOLOGY,

    2018/12/1

    Kai Saitoh 1)、Masaaki Akamatsu 1)、Kenichi Sakai 1)、2)、Hideki Sakai 1)、2)、Taku Ogura 2)、3)

    Tokyo University of Science 1)、 Reserch Institute for Science & Technology 2)、Lion Corporation3)

Environment and Human Safety

  • Ring study of ADRA, in chemco alternative test method for skin sensitization, aimed at revised guideline

    The 35th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2022/11/18-11/20

    Hiroaki Yamaga,Shinichi Watanabe

  • Verification of Amino acid Derivative Reactivity Assay-Organic Solvent (ADRA-OS): Evaluation of Epoxides and Surfactants

    ICT 2022 – XVIth International Congress of Toxicology

    2022/9/18-9/21

    Ryo Koizumi

  • Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human Buccal Oral Mucosal Model -Analysis of Mechanisms of Toxicity in Mucosal Cells-

    The 49th Annual Meeting of the Japanese Society of Toxicology

    2022/6/30-7/2

    Seiya Aizawa

  • Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.

    Journal of Applied Toxicology volume42, Issue 6 1078-1090 Jun 2022

    2022/1/18

    Yusuke Yamamoto 1), Masaharu Fujita 1) , , Shinichi Watanabe 2),Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)

    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation,
    3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,

  • The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories.

    Journal of Applied Toxicology volume42, Issue 2 318-333 Feb 2022

    2021/12/1

    Masaharu Fujita 1), Yusuke Yamamoto 1), Sayaka Wanibuchi 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kazuya Takeuchi 5), Kohei Kamiya 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Hajime Kojima 9), Toshihiko Kasahara 1), Atsushi Ono 10)

    1) Safety Evaluation Center, Fujifilm Corporation,2) Lion Corporation, 3)Chemical Safety Department, Mitsui Chemicals, Inc., 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5) Biological Research Laboratories, Nissan Chemical Corporation, 6)Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 10) Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University,

  • Development of a new alternative skin sensitization test for the evaluation of highly hydrophobic substances:Amino acid Reactivity Assay-Organic Solvent (ADRA-OS) reaction system

    The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Hiroaki Yamaga (Joint research with Fujifilm)

  • Validation Study of Epidermal Sensitization Assay (EpiSensA), an Alternative Method for Skin Sensitization Testing

    The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Junko Ueno

  • The Japanese Society for Alternatives to Animal Experiments  Best Presentation Award
    A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The 34th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2021/11/11-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society of Toxicology Excellent Research Presentation Award
    Development of an Alternative Method for Oral Mucosal Irritation Testing Using a Human 3D Cultured Oral Mucosa Model -Validation of Criteria for Classification of Irritation/No Irritation

    The 48th Annual Meeting of the Japanese Society of Toxicology

    2021/7/7-7/9

    Seiya Aizawa(Joint research with Kao Corporation and Sunstar Corporation)

  • Amino acid derivative reactivity assay-organic solvent reaction system: A novel alternative test for skin sensitization capable of assessing highly hydrophobic substances

    Journal of Applied Toxicology volume41, Issue 10 1634-1648 Oct 2021

    2021/2/26

    Hiroaki Yamaga 1),Shinichi Watanabe 1),Masaharu Fujita 2),Yusuke Yamamoto 2),Toshihiko Kasahara 2),Shinsuke Kataoka 1)

    1)Safety Science Research Laboratories, Lion Corporation
    2)Safety Evaluation Center, Fujifilm Corporation

  • Introduction of EpiSensA, an alternative method for skin sensitization test using 3D human epidermis model, for evaluation of poorly water-soluble substances

    The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Junko Ueno

  • The Japanese Society for Alternatives to Animal Experiments  President's Special Award
    A study of oral mucosal irritation testing with a reconstructed human gingival mucosal model

    The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Joint research with Kao Corporation and Sunstar Corporation

  • The Japanese Society for Alternatives to Animal Experiments
    Validation study of the Epidermal Sensitization Assay (EpiSensA), an alternative method for skin sensitization testing (Phase I of institutional reproducibility)

    The 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2020/11/12-11/13

    Joint research with Kao Corporation, KOSE Corporation and Food and Drugs Safety Center

  • Case studies of microbial problems in the manufacturing genba of cosmetics and personal care products

    FRAGRANCE JOURNAL 2020/May No.479(Vol.48/No.5)

    2020/5/1

    Masahiko Otani

  • New approach to evaluation and classification of irritation intensity of oral care ingredients using a three-dimensional human buccal mucosal model.

    Society of Toxicology 59th Annual Meeting

    2020/3/15-19

    Joint research with Kao Corporation and Sunstar Corporation

  • Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

    Journal of Applied Toxicology volume40, Issue 6 843-854 Jun 2020

    2020/2/12

    Miyuki Akimoto 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Hiroaki Yamaga 2), Kousuke Yoshida 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), | Kei Kusakari 5), Kohei Kamiya 5), Kohichi Kojima 6), Tsuyoshi Kawakami 7), Hajime Kojima 8), Atsushi Ono 9), Toshihiko Kasahara 1), Masaharu Fujita 1)

    1)Fujifilm Corporation, Safety Evaluation Center, 2)Lion Corporation, 3)Mitsui Chemicals, Inc. Chemical Safety Department, 4)Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory, 5)Nissan Chemical Corporation, Biological Research Laboratories, 6)Food and Drug Safety Center, Hatano Research Institute, 7)Division of Environmental Chemistry, National Institute of Health Sciences, 8)Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 9)Okayama University

  • Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice

    Journal of Chromatography B , Volume1137, 15 January 2020, 121881

    2020/1/15

    Kanako Yuyama 1), Yoshitaka Nakamura a), Riho Tateyama a), Rieko Arakaki b), Takuya Tsutsui a), Naozumi Ishimaru b),

    a)Research & Development Headquarters, Lion Corporation, b)Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences,

  • The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

    Journal of Applied Toxicology volume39, Issue 11 1492-1505 Nov 2019

    2019/7/17

    Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Takashi Sozu 8), Takuto Nakayama 8),Takeru Kusao 8), Jon Richmond 9), Kleinstreuer Nicole 10), Bae-Hwa Kim 11), Hajime Kojima 12), Toshihiko Kasahara 1), Atsushi Ono 13)

    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Chemical Safety Department, Mitsui Chemicals, Inc, 4) Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 5) Biological Research Laboratories, Nissan Chemical Corporation, 6) Division of Environmental Chemistry, National Institute of Health Sciences, 7) Food and Drug Safety Center, 8) Faculty of Engineering, Tokyo University of Science, 9) Dr. Jon Richmond: Advice and Consultancy,10) NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, 11)College of Natural Sciences Keimyung University,12) Biological Safety Research Center, Division of Risk Assessment, National Institute of Health Sciences, 13) Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Division of Pharmaceutical Sciences, Okayama University,

  • Development of an Alternative Oral Mucosal Irritation Test Using a Three-dimensional Human
    Buccal Mucosal Model - Study on Setting of Oral Mucosal Irritation Evaluation Flow for Raw
    Materials and Products for Oral Care -

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2019/6/26-6/28

    Seiya Aizawa

  • Development of ADRA-OS(Organic solvent reaction System)for poorly water-soluble sensitizers

    The 32nd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2019/6/26-6/28

    Hiroaki Yamaga

  • The Study of Utility of a Three-dimensional Human Buccal Mucosal Model for Oral Mucosal Irritation Prediction of Raw Materials for Oral Care Supplies by the Three Facilities

    The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2018/11/23-11/25

    Seiya Aizawa

  • Current state and Issues of utilization of animal experiment alternative methods in safety evaluation by chemical industry

    The 31st Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

    2018/11/23-11/25

    Shinichi Watanabe

  • Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay

    Journal of Applied Toxicology volume39, Issue 2 191-208 Feb 2019

    2018/9/16

    Masaharu Fujita 1), Yusuke Yamamoto 1), Shinichi Watanabe 2), Tsunetsugu Sugawara 2), Koji Wakabayashi 3), Yu Tahara 3), Nobuyuki Horie 4), Keiichi Fujimoto 4), Kei Kusakari 5), Yoshihiko Kurokawa 5), Tsuyoshi Kawakami 6), Kohichi Kojima 7), Hajime Kojima 8), Atsushi Ono 9), Yasuhiro Katsuoka 1), Hideto Tanabe 10), Hiroshi Yokoyama 10), Toshihiko Kasahara 1)

    1) Safety Evaluation Center, Fujifilm Corporation, 2) Lion Corporation, 3) Mitsui Chemicals, Inc., Chemical Safety Department 4) Sumitomo Chemical Co., Ltd., Environmental Health Science Laboratory, 5) Nissan Chemical Corporation, Biological Research Laboratories, 6) National Institute of Health Sciences, Division of Environmental Chemistry,7) Food and Drug Safety Center, Hatano Research Institute, 8) National Institute of Health Sciences, Biological Safety Research Center, Division of Risk Assessment, 9) Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Division of Pharmaceutical Sciences,10) Fujifilm Corporation, Research & Development Management Headquarters, Analysis Technology Center

  • A Study of Utility of a Three-dimensional Human Buccal Mucosal Model and Gingival Model for Oral Mucosal Irritation Evaluation

    The 45th Annual Meeting of the Japanese Society of Toxicology

    2018/7/18-7/20

    Seiya Aizawa

Analysis Technology

  • Contribution of analytical chemistry to Lion Corporation's R&D innovation

    2023 Analysis Innovation Meeting

    2023/01/17

    Atsushi Sato

  • Study of Associations Between Pain Severity-Based Phenotypes and Metabolomic Changes During the Menstrual Cycle by Plasma Metabolomics

    19th Annual International Conference of the Metabolomics Society

    2023/6/18-6/22

    Atsushi Sato

  • Bactericidal effect analysis of 3-methoxy-3-methyl-1-butanol -Effect on microbial cells-

    The Society for Antibacterial and Antifungal Agents, Japan

    2022/9/26-9/27

    Keisuke Nakajima

  • The society for Antibacterial and Antifungal Agents, Japan, Poster Award
    Analysis of Bactericidal Effects of Solvents -Effects in Surfactant Composition Systems-

    The society for Antibacterial and Antifungal Agents, Japan

    2021/9/8-9/9

    Keisuke Nakajima

  • The Role of MS in the Development of Daily Use Products -Study of Odor Component Analysis-

    The 47th Biological Mass Spectrometry Conference (BMS202020/2021)

    2021/7/12-7/14

    Takuya Tsutsui

  • Contribution to the work of expanding communication of products for dentists using atomic force microscopy (AFM)

    The Japan Society for Analytical Chemistry

    2021/5/22-5/23

    Ryota Hashimoto

  • Contribution to the development work of functional foods using LC-MS technology

    The Japan Society for Analytical Chemistry

    2020/5/23-5/24

    Atushi Satoh

Life Sciences Technology

  • Proposal of a simulation model that visualizes the risk of children coming into contact with viruses in elementary schools

    The 37th Annual Conference of the Japanese Society for Artificial

    2023/06/06

    Keisuke Nakajima

  • Visualization of Propionibacterium acnes with Visible Light Using Deep Learning

    International Workshop on Advanced Image Technology 2023

    2023/1/9-1/11

    Sota Watanabe

  • The relationship between lifestyle and cold morbidity in workers

    The 81st Annual Meeting of Japanese Society of Public Health

    2022/10/7-10/9

    Ayumi Sawada

  • Simulation modeling of virus contact infection in the home when returning home.

    The 37th Annual Meeting of Japanese Society for infection Prevention and Control

    2022/6/16-6/18

    Yukari Sekine

  • Visualization of infection risk by human behavior analysis and development of virus control technology

    The 102nd CSJ Annual Meeting (2022)

    2022/3/23-3/26

    Takeshi Takizawa

  • Factor analysis of changes in vitality of workers during the COVID-19 pandemic

    The 28th Annual Meeting of the Japanese Society for Chronobiology

    2021/11/20-11/21

    Takahiko Suiko

  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    The 28th Annual Meeting of the Japanese Society for Chronobiology

    2021/11/20-11/21

    Ayumi Sawada

  • Sleep Quality and Productivity Decline under a New Coronavirus Infection Epidemic

    The 46th Annual Meeting of Japanese Society of Sleep Research

    2021/9/23-9/24

    Yuki Nagamori

  • Effects of introducing sleep improvement services to workers on their mental and physical health and organizational status

    The 46th Annual Meeting of Japanese Society of Sleep Research

    2021/9/23-9/24

    Ayumi Sawada

  • Let's do what we want to do with good sleep habits! ~What I've learned from sleep research

    11th CSJ Chemistry Festa

    2021/9/22-9/24

    Takao Iwai

  • Functionality of Sake Yeast -Improvement of Sleep Quality

    23th Joint Yeast Symposium

    2021/9/2-9/3

    Tomomi Sano

  • Association between frequency of tooth brushing and health-related factors among workers

    Annual Meeting of the Japanese Society of Time-based Nutrition

    2021/8/27-8/28

    Takao Iwai

  • Development of an original in vitro exercise model and its application to the analysis of the mechanism of action of β-hydroxy-β-methylbutyrate (HMB)

    The 29th Annual Meeting of Japan Society of Exercise and Sports Physiology

    2021/8/20-8/21

    Satoko Satoh

  • Irregular meal timing is associated to the mental health in Japanese workers.

    Nutrients 2021, 13(8), 2775

    2021/8/13

    Yu Tahara 1), Saneyuki Makino 1), Takahiko Suiko 2), Yuki Nagamori 2), Takao Iwai 2), Megumi Aono 2), and Shi-genobu Shibata 1),

    1 Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda Univer-sity 2 Research and Development Headquarters, Lion Corporation

  • Improving sleep and productivity with solutions tailored to each person's sleep state

    Online seminar to introduce health management solutions([Organizer] Fair Work Co.)

    2021/6/29

    Takuya Ichinose

  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    The 141st Annual Meeting of the Pharmaceutical Society of Japan

    2021/3/26-3/29

    Takumi Mitsudome

  • "BtoBtoC business that aims to improve health and work productivity through better sleep."

    Kenkojumyo Report

    2021/3/4

    Megumi Aono

  • Basic knowledge of microorganisms and introduction of antibacterial and antiviral measures

    ATTS

    2020/10/16

    Seiichi Tobe

  • Influence of remote working on sleep during COVID-19 pandemic

    The 27th Annual Meeting of the Japanese Society for Chronobiology

    2020/9/26~9/27

    Takahiko Suiko

  • Improving Worker Productivity and Workplace Safety by Measuring Sleep Quality and Suggesting Sleep Improvement Methods

    The 27th Anniversary Conference of Japanese Society for Occupational Mental Health

    2020/7/4-7/5

    Takuya Ichinose

  • Creating a New Value of Sleep Health Care; A Healthy Body Provided by Good Sleep

    The 45th Annual Meeting of Japanese Cosmetic Science Society

    2020/6/12-6/13

    Tomomi Sano

  • Effects of muscle contraction on metabolomic profiling using in vitro exercise model

    The 2020 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2020/3/25-3/28

    Satoko Satoh

  • Effects of lutein and astaxanthin intake on the improvement of cognitive functions among healthy adults: a systematic review of randomized controlled trials

    Nutrients 2020, 12(3), 617

    2020/2/27

    Rui Nouchi 1),2), Takahiko Suiko 3), Eriko Kimura 3), Hiroki Takenaka 3), Michiaki Murakoshi 3), Akira Uchiyama 3), Megumi Aono 3), Ryuta Kawashima 2) ,4)

    1 Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC),Tohoku University, 2 Smart Aging Research Center (S.A.R.C.), Tohoku University, 3 Research and Development Headquarters, Lion Corporation, 4 Department of Functional Brain Imaging, In

  • Social Implementation Relay "Efficacy of Sleep Check & Care and Efforts at Hirosaki COI

    HealthyAging Innovation Summit

    2020/1/31

    Megumi Aono

  • Purpose of establishment and activities of the "Social Health Strategy Research Institute" aiming to improve social health and realize a sustainable symbiotic society

    Healthcare IT 2020

    2020/1/28-1/29

    Megumi Aono

  • The effects of sleep quality measurement and sleep care solution on health promotion and work productivity improvement.

    The 15th Japanese Society of Fatigue Science

    2019/5/18-5/19

    Yuki Nagamori

  • Japanese sake yeast supplementation reduces daytime fatigue via sleep quality improvement: a double-blind randomized placebo-controlled clinical trial

    International Society of Food Function

    2018/10/27-10/28

    Yuki Nagamori

  • Effects of Japanese sake yeast supplementation on human skin quality and analysis of its mechanism

    The 24th Conference of the European Sleep Research Society

    2018/9/25-9/28

    Kengo Oka

  • Japanese Society for food factors (2018)
    Skin Improvement by Sleep Supplement “Sake Yeast”

    Japanese Society for food factors

    2018/9/7-9/8

    Yuki Nagamori

  • Mechanism analysis of Japanese sake yeast induced non-rapid eye movement sleep.

    The 57th Annual Meeting of the Japan Oil Chemists' Society

    2018/9/4-9/6

    Yoshitaka Nakamura

  • Japanese sake yeast improves daytime fatigue

    The 43rd Annual Meeting of Japanese Society of Sleep Research

    2018/7/11-7/13

    Kaori Hirao

  • Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis

    The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/15-3/19

    Yuki Nagamori

  • The sleep enhancement supplement Japanese sake yeast improves skin quality in humans—A randomized, double-blind placebo-controlled clinical trial—

    Jpn Pharmacol Ther 2018 46(11)1851 - 1857

    2018

    Yuki Nagamori(LION)

  • Japanese sake yeast improves human fatigue and vitality: A double-blind, randomized controlled clinical trial

    Jpn Pharmacol Ther 2018 46(4)619 - 625

    2018

    Yuki Nagamori(LION)

Living and Fabric Care

  • Research on household fabric softener that maintains a smooth texture

    The Japan Research Association for Textile End-Uses

    2023/06/24

    Ayato Ueda

  • Research on household fabric softener that imparts a smooth texture

    ATC-16 16th Asian Textiles Conference

    2023/06/14

    Haruka Ebisawa

  • A Study of Laundry Experiences Based on Behavioral Use of Different Fabric Softeners -Qualitative Survey Using Semi-Structured Interview Method-

    The 18th Spring Annual Meeting of Japan Society of Kansei Engineering

    2023/03/06

    SAITO KAI

  • Mold in bathrooms -Influence of facilities and bathing behavior-

    Fungi in Human Life Vol.15 No.2(32) 2022

    2022/12/1

    Hiroshi Yamagishi

  • Developing a method to remove stubborn bathtub keratin grime without scrubbing

    2nd World Congress on Oleo Science, WCOS2022

    2022/8/23-9/3

    Shinya Sudo

  • Synergic Effects of Surfactant and Chelating Agent on Stubborn Keratin Grime for Easy Cleaning

    Journal of Oleo Science 70, (12) 1769-1776 (2021)

    2021/12/3

    Shinya Sudo

  • Preventing odor when drying clothes indoors

    2021 AOCS Annual Meeting & Expo

    2021/5/3-5/14

    Masanori Fushitani

  • Visualization of skin texture - Performance evaluation of detergents for clothing by X-ray CT

    Rigaku Jounal

    2020/10/21

    Yukari Sekine

  • Efforts to increase awareness of laundry methods using QR codes

    Symposium on Cleaning

    2020/10/5-10/7

    Yuki Saito

  • Introduction to Commodities and Services by Means of Up-to-date Technological Studies by Companies Development of "Anti-Smelling Top Super NANOX"

    The Japan Research Association for Textile End-Uses

    2020/6/20-6/21

    Keisuke Mori

  • Efforts with apparel manufacturers to raise awareness of washing methods

    The Japan Research Association for Textile End-Uses

    2020/6/20-6/21

    Yuki Saito

  • Design of nanoscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    Chemical Engineering Science volume 203, 10 August 2019, Pages 113–121

    2019/3/27

    Motoyuki Iijima a),b) Masahiro Hayakawa b), Junichi Tatami a),b), Koichiro Nakamura c), Shinichi Nagashima c)

    a)Faculty of Environment and Information Sciences, Yokohama National University, b) Graduate School of Environment and Information Sciences, Yokohama National University,c)Research and Development Headquarters, Lion Corporation,

  • Current Status and Control of Microbiological Contamination in Indoor Environment
    Mold Pollution and Control in the Bathroom

    JOURNAL OF ANTIBACTERIAL AND ANTIFUNGAL AGENTS, JAPAN,Vol.47,No.6,pp.233−237(2019)

    Hiroshi Yamagishi

  • Talk about “TOP”

    The Japan Research Association for Textile End-Uses

    2018/11/20-11/26

    Ishizuka Tomotaka

  • Basic lecture "Preservateve efficacy test method"

    45th Annual Meeting, The society for Antibacterial and Antifungal Agents, Japan

    2018/11/14

    Masahiko Otani

  • Evaluation of the Effect of the Characteristic of the Dish Washing Detergent has influence on the Psychophysiological State and Behavior

    The 20th Japan Society of Kansei Engineering

    2018/9/4-9/6

    Masaki Miyajima

  • Analysis of a burden reduction effect during the laundry using liquid detergent with new value

    The 20th Japan Society of Kansei Engineering

    2018/9/4-9/6

    Shota Okeda

  • Study on the washing method of urine-smelling clothing

    The Japan Research Association for Textile End-Uses

    2018/6/23-6/24

    Haruka Takahashi

  • Development of Top HYGIA

    Journal of the Japan Research Association for Textile End-uses Vol 59 6 2018

    2018/6/28

    Nanami Sasaki

  • Effects of various microwave cookers on the microwave cooking

    The Japan Society of Home Economics

    2018/5/25-5/27

    Shuhei Kameyama

  • Study on bacteria flora to prevent fabric odors

    2018 AOCS Annual Meeting and & Expo

    2018/5/6-5/9

    Keisuke Mori

  • Relationship of bacteria and odor on washing and solution for suppressing the odor

    Sentaku no kagaku

    2018/5/1

    Keisuke Mori

  • Study on evaluation techniques (self-evaluation and biometorics response) for touch feeling given with fabric softner

    Technical Information Institute Co., Ltd
    Product development and evaluation techniques that appeal to the sensibility of the human

    2018

    Emiko Hashimoto

  • Case Study of Fragrance Evaluation for Fabric Softener

    Technical Information Institute Co., Ltd
    Product development and evaluation techniques that appeal to the sensibility of the human

    2018

    Shiori Nakamura

  • About the touch feeling and its textile properties obtained with new laundry detergent

    The society of Fiber Science and Technology, Japan

    Aiko Tai

Medicated Care

  • Examination of irritant factors affecting corneal epithelial repair and corneal epithelial repair effect of retinol palmitate

    The 143rd Annual Meeting of the Pharmaceutical Society of Japan

    2023/03/25

    Haruki Horiuchi

  • Investigation of the inhibitory mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

    The 50th Meeting of the Japanese Society of Ulcer Research

    2023/02/03

    Masayoshi Kobayashi

  • Examination of the inhibitory mechanism of NSAIDs-induced gastrointestinal mucosal damage by acetaminophen

    The 44th Annual Meeting of Japanese Association for the Study of Pain

    2022/12/2-12/3

    Keiko Seki

  • Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury

    Ulcer Research Vol 49 10-15

    2022/10/25

    Keiko Seki

  • Relationship between changes in the intestinal microbiome and the protective effect of acetaminophen against NSAIDs-induced small Intestinal mucosal damage

    Ulcer Research Vol 49 45-48

    2022/10/25

    Yuto Aita

  • The effects of sucralfate on chronic stress-induced duodenal low-grade inflammation

    Jpn Pharmacol Ther 2022 50(6)1003 - 1011

    2022/6/20

    Mayumi Tsuri

  • Japanese Sake Yeast Improves the Quality of Sleep

    Journal of the Brewing Society of Japan

    2022/4/1

    Tomomi Sano

  • Relationship between NSAIDs-induced small intestinal mucosal injury and microbiome -Elucidation of the injury suppression mechanism by acetaminophen-

    The 108th General Meeting of the Japanese Society of Gastroenterology

    2022/4/21-4/23

    Yuto Aita

  • Investigation of the inhibitory action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury

    The 108th General Meeting of the Japanese Society of Gastroenterology

    2022/4/21-4/23

    Keiko Seki

  • Received the 49th Meeting of the Japanese Society of Ulcer Research (2022) Encouragement Award
    「Investigation of the action mechanism of acetaminophen on NSAIDs-induced small intestinal mucosal injury」

    The 49th Meeting of the Japanese Society of Ulcer Research Encouragement Award

    2022/2/11-2/13

    Keiko Seki

  • Elucidation of the relationship between suppression of NSAIDs-induced small intestinal injury by acetaminophen and bacterial flora

    The 49th Meeting of the Japanese Society of Ulcer Research

    2022/2/11-2/13

    Yuto Aita

  • Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction

    The Ocular Surface

    2021/10/16

    Tomo Suzuki a),b),Koji Kitazawa a), Yuko Cho a),b), Masataka Yoshida c), Takashi Okumura c), Atsushi Sato c), Shigeru Kinoshita d)

    a) Department of Ophthalmology, Kyoto Prefectural University of Medicine
    b) Department of Ophthalmology, Kyoto City Hospital Organization
    c) Research and Development Headquarters, Lion Corporation,
    d) Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine

  • Comparison of drug delivery behavior to pain-related tissues by different routes of administration using loxoprofen sodium hydrate

    The 54th JPA Congress of Pharmacy and Pharmaceutical Science

    2021/9/19-9/20

    Yasushi Kudo

  • Usefulness of acetaminophen in ibuprofen-induced small bowel injury

    (Journal of Japanese Society of Gastroenterology) Nihon Shokakibyo Gakkai Zasshi. 2021;118(9):840-850

    2021/9/10

    Miyu Kitahara, Yuki Sakamoto, Ryuto Kimura, Keiko Seki

  • Improvement of Evaporative Dry Eye with Meibomian Gland Dysfunction in Model Mice by Treatment with Ophthalmic Solution Containing Mineral Oil

    Translational Vision Science & Technology  Volume 10(21); 2021 April

    2021/4/20

    Keisuke Watanabe 1), Masataka Yoshida 1), Takashi Okumura 1), Takayuki Sassa 2), Akio Kihara 2), Akira Uchiyama 1)

    1) Research and Development Headquarters, Lion Corporation, 2)Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences

  • Inhibition mechanism of NSAIDs-induced small intestinal mucosal injury by acetaminophen

    The 107th General Meeting of the Japanese Society of Gastroenterology

    2021/4/15-4/17

    Keiko Seki

  • Inhibition of Ibuprofen-Induced Small Intestinal Mucosal Injury by Acetaminophen in Relation to Bacterial Flora

    The 107th General Meeting of the Japanese Society of Gastroenterology

    2021/4/15-4/17

    Yuto Aita

  • Comparison of the drug efficacy of OTC antipyretic analgesic ingredients using a mouse model of tension-type headache

    The 48th Congress of the Japanese Headache Society

    2020/11/7-11/8

    Yuki Ogawa

  • Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells

    Journal of Ocular Pharmacology and Therapeutics Vol. 36, No. 9 / Nov 2020

    2020/11/5

    Kyohei Kabashima 1), Akira Murakami 2), Nobuyuki Ebihara 3)

    1) Lion Corporation Odawara Research Center, 2)Department of Ophthalmology, Juntendo University
    Graduate School of Medicine,3)Department of Ophthalmology, Juntendo University Urayasu Hospital,

  • Creation of a rat model of functional dyspepsia with chronic downregulation of tight junction component proteins

    Ulcer Research Vol 47 97-99

    2020/7/20

    Mayumi Tsuri、Takuya Hayakawa

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats

    Heliyon, Volume 6, Issue 5, May 2020

    2020/5/24

    Mizuho Niibori 1),Yasushi Kudo 1),Takuya Hayakawa 1), Keiko Ikoma-Seki Ryosuke Kawamata 1), Atsushi Sato 1), Kazue Mizumura 2),3)

    1)Research & Development Headquarters, Lion Corporation,
    2) Department of Physiology, Nihon University School of Dentistry,
    3) College of Life and Health Sciences, Chubu University,

  • The Effect of Nonpolar Lipids in Meibum on Stability of Tear Film Lipid Layer against Compression-Expansion Cycles

    J. Oleo Sci. 69, (5) 429-436 (2020)

    2020/2/4

    Masataka Yoshida 1), Masato Yamaguchi 2) Atsushi Sato 1) , Miyuki Miyake 1) , Nobuhito Tabuchi 1) , Ryo Kon 1) , and Ken-ichi Iimura 3)

    1) Research and Development Headquarters, Lion Corporation, 2)Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University, 3) Division of Engineering and Agriculture, Graduate School of Regional Development and Creativity, Utsunomiya University,

  • Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

    PLOS ONE 2019; 14(11): e0224809.

    2019/11/6

    Tetsuhiro Shimodaira 1, Shigeo Mikoshiba 1, Toru Taguchi 2 3

    1)Lion Corporation, 2)Department of Physical Therapy, Niigata University of Health and Welfare, 3)Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare,

  • The Analgesic Effect of Aspirin on Inflammatory Pain in Rats Is Affected by Pain Intensity and Administration Timing

    YAKUGAKU ZASSI (Journal of the Pharmaceutical Society of Japan) 140 (1) 91-97, 2020

    2019/10/25

    Miu Kitahara,Keiko Seki, Tatsuyuki Midorikawa, Junya Arita, and Akira Uchiyama
    Research & Development Headquarters, Lion Corporation,

  • A thin layer of sucrose octasulfate protects esophageal mucosal epithelium against reflux esophagitis

    AAPS 2018 PHarmSCi 360

    2018/11/4-11/7

    Takuya Hayakawa

  • Acetylsalicylic acid and conventional NSAIDs ameliorate muscular mechanical hyperalgesia through mechanisms other than COX-2 inhibition

    IASP 2018 World Congress on Pain

    2018/9/12-9/16

    Tetsuhiro Shimodaira

  • Acetylsalicylic acid and loxoprofen ameliorate secondary hyperalgesia through mechanisms other than COX-2 inhibition in a rat model of osteoarthritis

    IASP 2018 World Congress on Pain

    2018/9/12-9/16

    Yasushi Kudo

  • Influence of Non-Polar Lipids and Polar Lipids on Tear Film Lipid Layer Stability

    The 69th Divisional Meeting of Division of Colloid and Surface Chemistry

    2018/9/18-9/20

    Masataka Yoshida

  • Vitamin A and Ery Eye

    Food and Medicine

    2018/9/1

    Nobuhito Tabuchi

  • Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in a rat osteoarthritis model —Effects of aspirin on ASIC3 expression and glial cells—

    The 40th Annual Meeting of Japanese Association for the Study of Pain

    2018/6/15-6/16

    Mizuho Niibori

  • Relationship between Meibum Composition and Eye Fatigue in Meibomian Gland Dysfunction Patients

    The 123rd Annual Meeting of the Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Changes in Meibum Composition with Aging and Meibomian Gland Dysfunction

    The 123rd Annual Meeting of the Japanese Ophthalmological Society

    2018/4/18-4/21

    Masataka Yoshida

  • Influence of Saturated Non-Polar Lipids on Tear Film Lipid Layer Stability

    The 98th CSJ Annual Meeting (2018)

    2018/3/20-3/23

    Masataka Yoshida

  • Structural Analysis of Tear Film Lipid Layer in Compression-Expansion Cycles

    The 98th CSJ Annual Meeting (2018)

    2018/3/20-3/23

    Masataka Yoshida

  • Hot Topics Award at Annual Meeting of Japan Society for Bioscienece 2018 , Biotechnology, and Agrochemistory
    「Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis」

    The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/16

    ○Satoko Sato 1)、Yusuke Takamura 1)、Ikkou Yamana 1)、Mitsuru Nomura 1)、Akira Uchiyama 1)、Yasuro Furuichi 2)Yasuko Manabe 2)、Nobuharu Fujii 2)

    1)Research & Development Headquarters, LION Corporation, 2)Graduate School of Human Health Sciences, Tokyo Metropolitan University

  • Comparison of effects of antacids on NSAIDs-induced gastric damages

    Ulcer Research Vol 45 85-89

    2018

    Kudo Yasushi

  • Foundation, Oil and Fat Industury Kaikan, 62th Excellent article award in Oil and Fat technology
    「Membrane Permeation of Giant Unilamellar Vesicles and Corneal Epithelial Cells with Lipophilic Vitamin Nanoemulsions」

    Oil & Fat Industry Kaikan Award

    Miyuki Miyake 1), Masatoshi Kurioka 1), Masahiro Takagi 2)

    1)Lion Corporation,2)Japan Advanced Institute of Science and Technology

Body Care

  • Study of SNPs related to visceral fat reduction effect of lactoferrin

    ifia JAPAN 2023

    2023/05/19

    Ayumi Matsuno

  • Maltotetraose alleviates chronic itch by inhibiting Substance P-Neurokinin 1 receptor pathway

    International Societies for Investigative Dermatology 2023

    2023/05/10

    Keisuke Yoshida

  • Relationship between menstrual pain and related disorders and living behavior in working women

    The 93rd Annual Meeting of the Japanese Society for Hygiene

    2023/03/02

    Kanako Yuyama

  • Young Investigator Excellent Abstract Award
    「A study on the association between anti-obesity effects of lactoferrin and genetic variations」

    22nd IUNS-ICN International Congress of Nutrition
    Young Investigator Excellent Abstract Award

    2022/12/6-12/11

    Kanae Nakamura

  • A study on the association between anti-obesity effects of lactoferrin and genetic variations

    22nd IUNS-ICN International Congress of Nutrition

    2022/12/6-12/11

    Kanae Nakamura

  • Associations between the health benefits of lactoferrin intake and genetic polymorphism

    JSoFF2022

    2022/10/22-10/23

    Daisuke Nishiura

  • "Japan Lactoferrin Society Award Tomita Award" Study of SNPs related to visceral fat reduction effect of lactoferrin

    10th Annual Scientific Meeting "Japan Lactoferrin Society Award Tomita Prize" (Applied category)

    2022/10/15

    Ayumi Matsuno

  • Study of SNPs related to visceral fat reduction effect of lactoferrin

    Japanese Association for Lactoferrin

    2022/10/15

    Ayumi Matsuno

  • Research on the Long-lasting Antibacterial Effects after Using Hand Soap

    Japan Oil Chemists' Society Cleaning & Detergent Division

    2022/10/11-10/14

    Arata Miyachi

  • Research on the Long-lasting Antibacterial Effects after Using Hand Soap

    The Society for Antibacterial and Antifungal Agents, Japan

    2022/9/26-9/27

    Masashi Tachikawa

  • Analysis of the mechanism of individual variabilities in the occurrence of menstrual pain by metabolomics (Part 2) - Clinical study using finger-prick blood metabolomics.

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Kanako Yuyama

  • Analysis of the mechanism of individual variabilities in the occurrence of menstrual pain by metabolomics (Part 1) - Development of finger-prick blood metabolomics.

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Atsushi Sato

  • Characterization of proton T2 relaxation time of bovine lactoferrin powder before and after high-temperature storage

    LWT - Food Science and Technology Volume 163, 15 June 2022, 113521

    2022/6/15

    Takumi Mitsudome

  • Study of SNPs related to visceral fat area and BMI reduction effect of lactoferrin

    The 76th Annual Meeting of Japan Society of Nutrition and Food Science

    2022/6/10-6/12

    Ayumi Matsuno

  • Decreased Frequency of Mental Workload-Induced Subjective Hot Flashes Through Gum Massage: An Open-Label, Self-Controlled Crossover Trial

    Women's Health Reports

    2022/3/8

    Kanako Ichinose

  • Hair evaluation method based on the actual situation of consumers

    The 58th SOCIETY OF COSMETIC CHEMISTS OF JAPAN

    2022/2/18

    Izumi Oishi

  • Well-being as a Key Factor for the Creation of Sustainable Local Towns, People, and Workplaces: An Introduction to Well-being Management Initiatives in Ehime, a Region that Sees a Ray of Light in Solving Local Problems

    Well-being Expo & Conference 2021 Autumn

    2021/11/4-11/5

    Takuya Ichinose

  • Approaches to Visualizing the Effectiveness of Care Focusing on Virus Contact Transmission in the Home

    Symposium on Cleaning

    2021/10/12-10/15

    Keiko Otake

  • Research on the persistence of antibacterial and antiviral effects by hand washing

    Symposium on Cleaning

    2021/10/12-10/15

    Risako Toki

  • Development of materials and functional foods for dry mouth, eyes, and skin (dry syndrome)

    Health ingredients (Hi) Japan 2021 Food ingredients for Taste (FiT) Japan 2021 Safety & Technology (S-tec) Japan 2021 Food Long Life Japan (LL) 2021

    2021/10/6-10/8

    Takao Iwai

  • Proper hand washing, gargling, and disinfection methods and their effects

    The 72nd Divisional Meeting of Division of Colloid and Surface Chemistry

    2021/9/15-9/21

    Yuriko Omoto

  • Development of skin care detergents with excellent moisturizing and tactile properties

    Development and Latest Technology of Moisturizing Cosmetics for Prevention of Rough Skin and Hands

    2021/5/28

    Michihiro Suzuki

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2021

    2021/5/12-5/14

    Tsubasa Yamaguchi

  • Foot trouble due to sweat and odor and development of corresponding products

    FRAGRANCE JOURNAL 2020/3 No.477(Vol.48/No.3)

    2021/3/15

    Shinichi Nagashima

  • Washing Cosmetics

    Basic Cosmetic Technology Seminar

    2021/2/15-2/19

    Risako Toki

  • Technology Introduction of "Nice Slim Essence Lactoferrin" to be delivered to the intestines ~~Visceral Fat Reduction Mechanism and Enteric Coating Technology~

    Japanese Association for lactferrin

    2020/12/6

    Takumi Mitsudome

  • Ideas for preventing infections in the home and workplace, hand washing and cleaning

    The 59th Annual Meeting of the Japan Oil Chemists' Society

    2020/11/2-11/7

    Yukari Sekine

  • Application of Anionic Polymers in Cosmetics

    COSMETIC STAGE 15(1), 45-50, 2020-10

    2020/10/1

    Tomoki Sano

  • Intraoral Approach to Improve the Nasolabial Fold

    COSMETIC STAGE 14(6), 39-45, 2020-08

    2020/8/1

    Yujiro Endo

  • Washing the skin.

    The 119th Annual Meeting of the Japanese Dermatological Association

    2020/6/4-6/7

    Hotaka Asano

  • The visceral fat-reducing effect of enteric lactoferrin and its mechanism of action

    ifia/HFE JAPAN 2020

    2020/4/20-4/22

    Takumi Mitsudome

  • Effect of lactoferrin intestinal solvent on visceral fat reduction

    Functional Food Vol.14 No.2 2020

    2020

    Michiaki Murakoshi、Kanae Nakamura、Tomoji Ono

  • Enteric-coated lactoferrin decreases abdominal visceral fat in humans: a randomized, double-blind, placebo-controlled, parallel-group study

    Jpn Pharmacol Ther 2020 48(7)1179 - 1185

    2020

    Satoko Sato 1), Mitsuru Nomura 1), Akira Uchiyama 1), Ikuo Fukuhara 2)

    1)Research & Development Headquarters, Lion Corporation, 2) Fukuhara Clinic, Eniwa,

  • Effects of Coexistent Components on the Antiperspirant Action of Aluminium Chlorohydrate

    J. Soc. Cosmet. Chem. Jpn. 55(1): 45‐51(2020)

    2020

    Tomoki Sano, Wataru Shirae, Yuriko Omoto, Shinichi Nagashima, Atsunori Morigaki, Yasushi Kakizawa, Takaki Ikenishi Research & Development Headquarters, Lion Corporation,

  • A Study on a Longitudinal Evaluation Method Using Facial Expression Analysis to Capture Emotional Changes during Cosmetics Use

    The 18th Conference of the Japanese Society for Cognitive Psychology

    Eisuke Inagaki

  • Rooibos extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulate the M3 muscarinic acetylcholine receptor

    The 7th International Conference on Food Factors (ICoFF2019)

    2019/12/1-12/5

    Takao Iwai

  • Influence of low-molecular-weight aggregates on aggregate growth kinetics and physical properties of solid-state proteins during storage

    Eur. J. Pharm. Biopharm. Volume146, Jan 2020, Pages 10-18

    2019/11/16

    Takumi Mitsudome 1), Mitsutoshi Moribe 1),Yoshiyuki Obayashi 1), Akira Uchiyama 1),, Megumi Aono 1),

    1) Research & Development Headquarters, Lion Corporation,

  • Rooibos extract activates M3 muscarinic acetylcholine receptor and relieves human dryness

    Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • In vivo mechanism study on the dryness relief function of rooibos extract

    Japanese Society of Oral Medicine

    2019/9/20-9/23

    Takao Iwai

  • Effects of Rooibos (Aspalathus linearis) Extract on Dryness of Mouth, Eye and Skin in Human

    The 28th Annual Meeting of the Japanese Society for Sjögren's syndrome

    2019/9/13-9/14

    Takao Iwai

  • Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice

    Journal of Oral Biosciences
    Volume 61, Issue 3, September 2019, Pages 179-182

    2019/8/7

    Rieko Arakaki 1), Aya Ushio 1), Satoru Kisoda 1), Mami Sato 1), Yoshitaka Nakamura 2), Kanako Yuyama 2), Riho Tateyama 2), Satoru Morishita 2), Noriyuki Monoi 2), Yasusei Kudo 1), Naozumi Ishimaru 3)

    1)Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences, 2)Research & Development Headquarters, Lion Corporation, 3) Department of Oral Molecular Pathology Tokushima University Graduate School of Biomedical Sciences,

  • Exercise and sports health claims in the system of Foods with Function Claims

    The 19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    2019/6/14-6/16

    Mitsuru Nomura

  • Rooibos (Aspalathus linearis) extract, containing eriodictyol-6-C-β-D-glucoside as the active component, stimulates exocrine glands via the M 3 muscarinic acetylcholine receptor

    Journal of Functional Foods
    Volume 55, April 2019, Pages 248-254

    2019/2/7

    Saori Nishimachi a),Takao Iwai a), Yoshitaka Nakamura a), Kanako Yuyama-Masuda a), Takuya Tsutsui a),Noriyuki Monoi a), Akira Uchiyama a),b), Seiji Nakamura c),

    a)Research & Development Headquarters, Lion Corporation, b)Division of Oral Health, Growth, and Development, Faculty of Dental Science, Kyushu University, c)Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University,

  • A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration

    Bioscience, Biotechnology, and Biochemistry, Volume 83, Issue 10, 2019, Pages 1851–1857

    2019/1/4

    Satoko Sato 1), Mitsuru Nomura 1), Ikko Yamana 1), Akira Uchiyama 1), Yasuro Furuichi 2), Yasuko Manabe 2), Nobuharu L Fujii 2),

    1),Research and Development Headquarters, Lion Corporation, 2),Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University ,

  • Relationship between female hormone and hair: Development of hair loss treatment

    The Journal of Japan Hair Science Association Vol.50,No.4(2018)

    2018/12/1

    Shunsuke Hiroshima

  • Quantitative Evaluation of Hair Growth in the Treatment of Hormone Replacement Therapy

    The Japan Society for Menopause and Women's Health

    2018/11/3-11/4

    Yujiro Endo

  • Effect of lactoferrin on energy expenditure enhancement in reprogrammed functional brown adipocytes

    25th International Conference of FFC

    2018/10/27-10/28

    Kanae Nakamura

  • Gene expression order attributed to genome reduction and the steady cellular state in Escherichia coli

    Front. Microbiol., 20 September 2018

    2018/9/20

    Bei-Wen Ying 1),2), Kazuma Yama 3)

    1)Institute of Biology and Information Science, East China Normal University
    2)Faculty of Life and Environmental Sciences, University of Tsukuba
    3)Research & Development Headquarters, Lion Corporation

  • Design of multiscale structured composite particles through mechanical process for fabricating a powder layer with rapid drying properties

    2018 SCEJ Autumn Meeting

    2018/9/18-9/20

    Koichiro Nakamura

  • Effects of lactoferrin on lipid metabolism in white adipocytes and brown adipocytes

    FOOD STYLE21

    2018/8/1

    Kanae Nakamura

  • Beta-hydroxy-beta-methylbutyrate (HMB) augments muscle contraction-induced protein synthesis via mTORC1 signaling in cultured L6 myotubes

    Experimental Biology 2018

    2018/4/21-4/25

    Satoko Satoh

  • Establishment of a new in vitro exercise model and its application to analyze the mechanism of beta-hydroxy-beta-methylbutylate (HMB) on the contraction-induced protein synthesis

    The 2018 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry

    2018/3/15-3/19

    Satoko Satoh

  • Relationship between female hormone and hair: Development of hair loss treatment

    The Journal of Japan Hair Science Association Vol.51,No.1(2019)

    2018/3/1

    Yujiro Endo

  • Effects of Rooibos(Aspalathus linearis)Extract on Dryness
    of Mouth, Eye and Skin in Human
    ―A Randomized, Double‒blind, Placebo‒controlled Study―

    Jpn Pharmacol Ther 2018 46(6)997 - 1003

    2018

    Takao Iwai

  • Anti-Obesity Effect of Lactoferrin; Subgroup Analysis Excluding Subjects with Obese and/or Hyper-LDL Cholesterolemia

     Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry , Volume 18, Number 1, 2018, pp. 105-109

    2018

    Tomoji Ono 1), Michiaki Murakoshi 1), Akira Uchiyama 1)

    1)Research & Development Headquarters, Lion Corporation

  • The effects of carotenoids intake for improvement of cognitive functions in healthy adults: a systematic review and meta-analysis of randomized controlled trials

    PROSPERO 2018 CRD42018110984

    2018

    Takahiko Suiko

  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes

    BioMetals

    2018

    Kanae Nakamura

Container and Packaging Development

  • Environmentally Conscious Design Guidelines for Cosmetic Containers and Packaging (2022)

    Japan Packaging Institute (JPI)

    2022/12/13

    Yasuhiko Ide

  • Lion's Approach to Container Development and Environmental Considerations

    The Japanese Society of Printing Science and Technology
    Gravure Research Group 13th Mini-Symposium

    2021/11/10

    Yasuhiro Makimura

  • Japan Packaging Institute,Best Presentation Award
    「Pre-detergent for laundry Development of new shower caps」

    Japan Packaging Institute

    2021/12/2

    Syunsuke Kawanishi

  • Development of the MIGACOT toothpaste set for office use

    Japan Packaging Institute

    2021/12/2

    Hironobu Hara

  • Toward Horizontal Recycling of Toiletry Pouches

    JSDA Engineering Containers and Waste Technical Committee

    2021/11/16

    Masahiro Honma

  • Examples of Corporate 3R+Renewable Initiatives

    Ichihara City Environmental Council

    2021/12/22

    Isamu Oishi

  • JAPAN PACKAGING CONTEST 2020 Package Design Award
    MIGACOT」

  • KINOSHITA Awards (43)[Research and Development Division] ;Japan Packaging Institute
    Look Plus Bathtub Cleansing

  • JAPAN PACKAGING CONTEST 2019 [Technical Packaging Award] ;Japan Packaging Institute
    Look Plus Bathtub Cleansing

  • JAPAN PACKAGING CONTEST 2019 [Toiletry Packaging Award] ;Japan Packaging Institute
    Kireikirei Medicated Hand Gel

  • Worldstar Winners 2020 - Household category;World Packaging Organisation
    Look Plus Bathtub Cleansing

Product Process Technology

  • Coarse-grained molecular simulation of surfactants using dissipative particle dynamics method

    2022/12/5-12/7

    Akinori Joko

  • Applying Methyl Ester Sulfonate(MES) to Liquid Detergent:Improving the Physical Properties of MES for the Manufacturing Process

    2021 AOCS Annual Meeting & Expo

    2021/5/28

    Kazuki Shimizu

  • Chemical Engineering Promoting Circular Economy Initiatives for the Recycled Use of Manufacturing Process Wastewater

    2021 SCEJ Autumn Meeting

    2021/9/23

    Naoki Nishikawa

  • Recent trend in water reuse technology "Recycling of Wastewater from the Manufacturing Process of Toiletry Products"

    The 22nd JSWE Symposium

    2019/9/5-9/6

    Yoshio Shimizu

  • New Methyl Ester Ethoxylate Derived from C18 Fraction of Palm Oil for Liquid Laundry Detergen

    2018 AOCS Annual Meeting & Expo

    2018/5/6-5/9

    Akinori Joko

  • Environmental Solution Technology,17,3 (2018)
    Recent trend in water reuse technology "Recycling of Wastewater from the Manufacturing Process of Toiletry Products"

    Environmental solution technology

    Naoki Nishikawa

Others

  • About CIE exhibition about TANO-LT

    SXSW2023 debriefing session

    2023/04/11

    Noriyuki Monoi

  • Science of Habit by Lion

    Gartner Data & Analytics Summit

    2023/04/04

    Yu-ichi Fujiwara

  • Association between breakfast meal categories and timing of physical activity of Japanese Workers

    Foods 2022, 11(17), 2609

    Takahiko Suiko

  • Effects of Differences of Breakfast Styles, Such as Japanese and
    Western Breakfasts, on Eating Habits

    Nutrients 2022, 14(23), 5143

    2022/12/2

    Takahiko Suiko

  • Lion Corporation’s Business Contents and Future Prospects

    Osaka Prefectural Government “10-Year-Old Rejuvenation Project: Creating a City for a Brighter Future” Conference

    2022/10/21

    Noriyuki Monoi

  • Current and Future Career Choice and Career Development of Women in Science

    Nissan Foundation Rikajo Training Forum

    2022/8/4

    Megumi Aono

  • Transformation of R&D operations utilizing digital technology

    FRAGRANCE JOURNAL 2022/2月号 No.500(Vol.50/No.2)

    2022/2/15

    Yu-ichi Fujiwara

  • 株式会社ハー・ストーリィ主催 女性のあした大賞(健康経営コース)(Japanese Only)
    「女性の健康課題解決のための企業ネットワーク・共通アンケートの構築によるリテラシー向上施策」

    Women's Tomorrow Grand Prize sponsored by Her Story Co., Ltd.

    2021/12/8

    Yujiro Endo

  • Health management and work style reform that is resilient to social change

    Social Health Strategy Research Institute

    2020/7/27-7/31

    Megumi Aono

  • THE NIKKAN KOGYO SHIMBUN, LTD., The 43rd Freshers Industrial Essay Contest, Part Ⅰ, 2nd place award
    「Breaking away from the same orderly manner, learning from telework」

    THE NIKKAN KOGYO SHIMBUN, LTD., The 43rd Freshers Industrial Essay Contest

    2020 Nov

    Saki Uemura

  • THE NIKKAN KOGYO SHIMBUN, LTD., The 42nd Freshers' Industrial Essay Contest, Part Ⅰ, prize of excellence
    「Creating real value for companies based on the latest team medicine」

    THE NIKKAN KOGYO SHIMBUN, LTD., The 42nd Freshers Industrial Essay Contest

    2019

    Haruka Morita

  • THE NIKKAN KOGYO SHIMBUN, LTD., The 41st Freshers Industrial Essay Contest, Part Ⅰ Award of excellence
    「Create real value in company: taking a hint from a model of the latest team based approach in medical」

    THE NIKKAN KOGYO SHIMBUN, LTD., The 41st Freshers Industrial Essay Contest

    2018/11/8

    Keita Sawada

  • Non-profit Incorporated Association,
    The Society of Chemical Engineers, Japan,

    The Society of Chemical Engineers, Japan(2018)

  • 第32回 粉体工業功績者表彰(Japanese Only)

  • 2018年度(第50回)油脂産業論文 佳作(Japanese only)
    「油脂産業と薬学的技術の融合による油脂ヘルスケアコンソーシアム構築 ~100歳まで生き生きと働ける社会の実現へ向けて~」

    Miyuki Maruyama

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