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Oral Technology

Eating, speaking, laughing—these and other functions of the mouth are crucial to our ability to live comfortably and enjoyably. Lion’s oral science research goes back more than a century. Aiming to improve consumers’ quality of life (QOL), we continue to build on this wealth of knowledge with research in such areas as non-destructive methods of treating dental caries, ways to reduce gingival inflammation based on molecular cytology, and the suppression of bacterial growth using proprietary biofilm models. In recent years, Lion has also partnered with external research institutions to elucidate the influence that conditions in the oral cavity have on the body’s overall health through joint research. By combining a wide range of technologies from in and outside the Lion Group, chiefly in the area of oral science, we strive to create new value through products ranging from those for oral care to food and pharmaceuticals.

R&D Case Study

Research Accomplishment—Oral Technology

Oral Technology

  • Stain removal efficacy of toothbrush with elastomer-coated bristles

    International Association for Dental Research(IADR)

    2023/06/21

    Phassamon Piyapakorn

  • Potassium Nitrate and Aluminum Lactate Containing Toothpaste Reduces Dentin Hypersensitivity

    International Association for Dental Research(IADR)

    2023/06/21

    Taiki Suzuki

  • Plaque Removal Efficacy of New Developed IoT Toothbrush with Brushing Navigation for Children

    International Association of Paediatric Dentistry

    2023/06/14

    Naoshi Kanamaru

  • Acceleration of toothpaste development using Bayesian optimization method

    The 37th Annual Conference of the Japanese Society for Artificial

    2023/06/06

    Eisuke Inagaki

  • Development and function of "Check-Up toothbrush standard type", a standard toothbrush for caries care

    Dental magazine 185

    2023/06/01

    Kuniyuki Itose, Naoshi Kanamaru

  • Validation of the usefulness of introducing dental checkups in the workplace

    The 66th Spring Meeting of the Japanese Society of Periodontology

    2023/05/26

    Yu Yamamoto

  • Effect of encouragement to see a dentist in occupational dental checkups on periodontal disease and systemic health

    The 66th Spring Meeting of the Japanese Society of Periodontology

    2023/05/26

    Kimura Mitsuo

  • Safety and plaque removal efficacy of Kid’s toothbrush with bendable/unbreakable neck

    2023 Central Interntional Dental Exhibition

    2023/05/24

    Ryosuke Hachisuka

  • Building a technical foundation for the development of oral care products

    The Japan Society for Analytical Chemistry

    2023/05/20

    Narumi Fujii

  • Comparison of oral microbiota before and after dental treatment in healthy and carious patients

    The 72nd General meeting of Japanese Society for Oral Health

    2023/05/19

    Takuya Inokuchi

  • The relationship between the introduction of dental checkups in the workplace and oral health and productivity

    The 72nd General meeting of Japanese Society for Oral Health

    2023/05/19

    Yu Yamamoto

  • Effects of chewing hard gummies on oral function in elementary school children

    The 61st Annual Conference of the Japanese Society of Pediatric Dentistry

    2023/05/18

    Keishi Sato

  • Fluoride and Caries prevention

    Tokyo Medical and Dental University

    2023/03/15

    Chika Akabane

  • Research on an EIS-type biosensor that detects cortisol in saliva

    The 70th JSAP Spring meeting 2023

    2023/03/15

    Yuki Maruyama

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    the 1st Annual Meeting of the Japan Saliva Care Research Association

    2022/11/27

    Yuki Maruyama

  • Inhibitory effects of toothpaste ingredients on novel coronavirus (SARS-CoV-2) infection in vitro

    the 1st Annual Meeting of the Japan Saliva Care Research Association

    2022/11/27

    Taku Iwamoto

  • Nanostructural analysis and age-related changes of apatite particles in human dentin

    The 44th Annual Meeting of the Japanese Society of Biomaterials

    2022/11/21-11/22

    Chika Akabane

  • Age-related changes in mechanical and esthetics properties in human dentin

    The 157th Meeting of the Japanese Society of Conservative Dentistry

    2022/11/10-11/11

    Yuriko Inomata

  • An in vitro study of the effect of berberine chloride on periodontal pathogenic bacteria in the oral microbiome

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Daisuke Watai

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Ryutaro Jo

  • Trends in detection of high prevalent oral bacteria during the first 60 months of life using a next-generation sequencer

    The 9th International Human Microbiome Consortium (IHMC) Congress 2022

    2022/11/8-11/10

    Kazuma Yama

  • Establishment of oral metabolome profiling method using mouth-rinsed water by capillary electrophoresis–mass spectrometry

    The 42nd Symposium on Capillary Electrophoresis (SCE2022)

    2022/10/26-10/28

    Yuki Maruyama

  • Relationship between oral care behavior and cold morbidity in workers

    The 81st Annual Meeting of Japanese Society of Public Health

    2022/10/7-10/9

    Ryutaro Jo

  • evelopment of EIS biosensors for rapid cortisol determination in saliva

    2022 International Conference on Solid State Devices and Materials (SSDM2022)

    2022/9/26-9/29

    Yuki Maruyama

  • Rapid measurement of EIS biosensors for detecting cortisol concentration in saliva

    The 83rd JSAP Autumn meeting 2022

    2022/9/20-9/23

    Yuki Maruyama

  • Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (2): Analysis of inter- and intra-day variation of fat-soluble metabolites by liquid chromatography-mass spectrometry

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Narumi Fujii

  • Evaluation of intra-individual variation of oral metabolites using mouth-rinsed water (1): Analysis of inter- and intra-day variation of water-soluble metabolites by capillary electrophoresis–mass spectrometry

    The 16th Metabolome Symposium

    2022/9/14-9/16

    Yuki Maruyama

  • Antiglycation of periodontitis preventive active ingredients in self-care oral hygiene products

    The 65th Autumn Meeting of the Japanese Society of Periodontology

    2022/9/2-9/3

    Tsuguno Yamaguchi

  • Phellodendron Bark Extract inhibits osteoclastogenesis by regulation of Nfatc1 gene expression

    The 14th Asian Pacific Society of Periodontology Meeting 2022

    2022/8/29-8/30

    Yu Yamamoto

  • An in vitro study of effects of Phellodendron Bark Extract on the periodontal pathogenic bacteria in the oral microbiome.

    The 14th Asian Pacific Society of Periodontology Meeting 2022

    2022/8/29-8/30

    Takuma Okuda

  • The effect of the flavor of children's toothpaste on the tooth-brushing behavior of pre-school children

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Tohru Ohki

  • The survey of taste sensitivity decrease in healthy subjects:
    Relationship between age, taste sensitivity and other factors

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Anna Tsuge

  • The 23rd (2021) Oils and Fats Technical Paper Excellence Award 「The inhibitory effects of toothpaste and mouthwash ingredients on the cellular infection process of SARS-CoV-2 infection in vitro」

    Oil & Fat Industry Kaikan Award

    2022/8/22

    Taku Iwamoto

  • Survey of taste sensitivity decrease in healthy subjects: Study on tastesensitivity decrease and the affecting factors in the 20s

    The 56th Annual Meeting of the Japanese Association for the Study of Taste and Smell

    2022/8/22-8/24

    Satoshi Tomeoka

  • Plaque removal efficacy of bendable/unbreakable safety toothbrush for infant

    The 4th International Symposium on Oral Care

    2022/7/11

    Ryosuke Hachisuka

  • Comparison of Healthy Versus before/after-Dental Treatment Oral Microbiome

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Takuya Inokuchi

  • Effectiveness of the new oral care device for children.

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Tomonari Kanasugi

  • Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Taku Iwamoto

  • Inhibitory Effects of Toothpaste Ingredients on SARS-CoV-2 Infection in vitro

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Riho Makino

  • Virucidal activity of oral care products against enveloped viruses

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Ryosuke Komatsu

  • Comparison of Healthy Versus before/after-Dental Treatment Oral Metabolome Profiles

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Narumi Fujii

  • Usefulness of Porcine Gingiva for Penetration Tests of Hydrophobic Ingredients

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Aya Ohkuni

  • Science behind toothbrush

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Reona Noda

  • Plaque removal efficacy of kids’ toothbrush with easily bent neck

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Sakiho Hayashida

  • Age-related deterioration of the human dentin

    International Association for Dental Research(IADR)

    2022/6/20-6/25

    Chika Akabane

  • Study of toothpaste applying fluoride retention and release technology

    The 156th Meeting of the Japanese Society of Conservative Dentistry

    2022/6/16-7/6

    Masashi Fujiki

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 infection in vitro

    European Federation of Periodontology 10th

    2022/6/15-6/18

    Kota Tsutsumi

  • Toothpaste technology that cares for the supportive tissue of teeth

    Dental Magazine 181 SUMMER

    2022/6/1

    Yu Yamamoto

  • Examination of fluoride retention technology of toothpaste using fluoride retention and release technology in the oral cavity

    The 71st General meeting of Japanese Society for Oral Health

    2022/5/13-5/27

    Mari Imazaki

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    The 71st General meeting of Japanese Society for Oral Health

    2022/5/13-5/27

    Mari Imazaki

  • Development of EIS type biosensor to detect cortisol in saliva

    The 69th JSAP Spring meeting 2022

    2022/3/22-3/26

    Yuki Maruyama

  • The relationship between malocclusion and habits in elementary school children in Kuroishi city, Aomori prefecture

    The 92nd Annual Meeting of the Japanese Society for Hygiene

    2022/3/21-3/23

    Keishi Sato

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    The Japan Dental Show 2021

    2022/3/4-3/6

    Mari Imazaki

  • Fluoride retention and release technology contributing to self-care of dental caries prevention

    Dental Magazine 180 SPRING

    2022/3/1

    Ryota Hashimoto

  • About the development and function of the nursing care toothbrush "Elac Toothbrush 620" that facilitates oral care for care recipients

    Dental Magazine 180 SPRING

    2022/3/1

    Aya Miyazawa, Naoshi Kanamaru

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports 12, Article number: 689 (2022)

    2022/1/13

    Yuki Maruyama 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Ryosuke Kawamata 1),Yuko Ichiba 1), KotaTsutsumi 1), Mitsuo Kimura 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1),Takashi Kumagai 3), TakujiYamada 2),5) & Shinji Fukuda 2),4),6),7)

    1)Research and Development Headquarters, Lion Corporation 2)Metabologenomics, Inc., 3)Hiyoshi Oral Health Clinics,4)Institute for Advanced Biosciences,Keio University,5)Department of Life Science and Technology,6)Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7)Transborder Medical Research Center, University of Tsukuba,

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    The 80th Annual Meeting of Japanese Society of Public Health

    2021/12/21-12/23

    Yukari Sekine

  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health

    2021/12/15

    Shinsuke Kataoka 1), Mitsuo Kimura 1),Tsuguno Yamaguchi 1), Kenji Egashira 1),Yu Yamamoto 1), Yasushi Koike 1),Yuki Ogawa 1), Chika Fujiharu 2), Toshiko Namai 2), Kanako Taguchi 2), Momoko Takahashi 2), Asami Kameda 2), Tomoka Kasen 2),Asami Hano 2), Konomi Kubota 2),Masayuki Sato 1), Hiroaki Yamaga 1), Kaori Nohara 2), Mikiko Shirasawa 2), Chika Sekine 2), Maki Fukuda 2), Arisa Aoki 2),Yurina Takeuchi 2), Misaki Mugiyama 2), Kenta Mori 4), Keigo Sawada 4) Yoichiro Kashiwagi 4), Masahiro Kitamura 4), Takeshi Hayashi 3),Tohru Nakagawa 3), Shinya Murakami 4)

    1)Research & Development Head Quarters, LION Corporation,2)The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3)Hitachi Health Care Center, Hitachi Limited,4)Faculty of Dentistry, Osaka University,

  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The 155th Meeting of the Japanese Society of Conservative Dentistry

    2021/10/28-11/10

    Masakazu Ono

  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    The 36th Conference of the Japanese Society of Pediatric Dentistry

    2021/10/17-10/23

    Ryosuke Hachisuka

  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64th Autumn Meeting of the Japanese Society of Periodontology

    2021/10/15-10/16

    Yu Yamamoto

  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Kazuma Yama

  • Inhibitory effects of toothpaste and mouthwash ingredients on SARS CoV 2 priming protease TMPRSS2

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Riho Makino

  • Inhibitory effects of toothpaste and mouthwash ingredients on
    the interaction between S-protein of SARS-CoV-2 and ACE2

    The 63rd Annual Meeting of Japanese Association for Oral Biology

    2021/10/9-10/11

    Mari Yutori

  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Taku Iwamoto

  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yukihide Aoyama

  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Yasushi Koike

  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry

    2021/10/1-10/3

    Kota Tsutsumi

  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE 2021; 16(9): e0257705.

    2021/9/17

    Riho Tateyama-Makino 1), Mari Abe-Yutori 1), Taku Iwamoto 1), Kota Tsutsumi 1), Motonori Tsuji 2) ,Satoru Morishita 1), Kei Kurita 1), Yukio Yamamoto 1), Eiji Nishinaga 1),Keiichi Tsukinoki 3)

    1)Research & Development Headquarters, Lion Corporation, 2)Institute of Molecular Function
    3)Division of Environmental Pathology, Department of Oral
    Science, Kanagawa Dental University

  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    2021 Eng. Res. Express 3 015006

    2021/5/11

    Ryosuke Hachisuka1),2), Reona Noda 2), Masayuki Yamaguchi 1)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation,

  • Survey on oral care habits and halitosis among general community residents

    The 18th Annual Meeting of the Japanese Society of Oral Care

    2021/4/17-4/18

    Chiyoko Uchiyama

  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The 101st CSJ Annual Meeting (2021)

    2021/3/19-3/21

    Mari Yutori

  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The 101st CSJ Annual Meeting (2021)

    2021/3/19-3/21

    Riho Makino

  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)

    2021/3/11

    Chika Akabane 1),2), Silvia Pabisch 2) , Wolfgang Wagermaier 2), Andreas Roschger 2),3) , Norio Tobori 1), Tomomichi Okano 1). Shinya Murakami 4), Peter Fratzl 2), Richard Weinkamer 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3)Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4)Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan

  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports 11, Article number: 861 (2021)

    2020/1/13

    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara,Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki

    Research and Development Headquarters, Lion Corporation,

  • Basic study on staining and removal of dentin by various beverages

    The 70th General meeting of Japanese Society for Oral Health

    2021/5/27-6/10

    Ayaka Iwasaki

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology

    2020/12/1

    Reona Noda,Shizuka Kawasaki,Ryosuke Hachisuka

  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    The 79th Annual Meeting of Japanese Society of Public Health

    2020/10/20-10/22

    Koichiro Hayashi

  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    The 31st General Scientific Meeting of Japan Academy of Esthetic Dentistry

    202010/3-10/4

    Ryota Hashimoto

  • Development of "RePERO", an application to support breath care

    The 71st Divisional Meeting of Division of Colloid and Surface Chemistry

    2020/9/13-9/16

    Kengo Oka

  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration

    2020/9/13

    Ken-ichiro Shibasaki

  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science

    2020/7/21-7/24

    Yuya Kimoto

  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The 152nd Meeting of the Japanese Society of Conservative Dentistry

    2020/6/11-6/12

    Rika Oda

  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    The 63rd Spring Meeting of the Japanese Society of Periodontology

    2020/5/29-5/30

    Kenji Egashira

  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    The 58th Annual Conference of the Japanese Society of Pediatric Dentistry

    2020/5/20-5/21

    Mai Satake

  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research(IADR)

    2020/3/18-3/21

    Tsuguno Yamaguchi

  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University

    2020/3/11

    Eiji Nishinaga

  • Inhibitory effects of pyrrolidone carboxylic acid on dentin demineralization and collagen degradation

    THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY(Jpn J Conserv Dent)

    2020/1/7

    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

  • Japan Institute of invention and innovation
    No.:6591988(Toothbrushes that can limit damage to the user's mouth)

    Japan Institute of Invention and Innovation

    2020/11/12

    Ryosuke Haschisuka

  • Asian Pacific Society of Periodontology Meeting 2019 Poster presentation competition Lab research 1st Prize
    「Effects of pyrrolidone carboxylic acid on dentin collagen degradation and demineralization」

    The 13th Asian Pacific Society of Periodontology Meeting 2019

    2019/9/28-9/29

    Shiori Ishii

  • Comparison of oral bacterial profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.

    Scientific Reports 9, Article number: 16124 (2019)

    2019/11/6

    Ryutaro Jo 1), Yuichiro Nishimoto 2), Kouta Umezawa 3), Kazuma Yama 1), Yuto Aita 1), Yuko Ichiba 1), Shinnosuke Murakami 2),4), Yasushi Kakizawa 1), Takashi Kumagai 3), TakujiYamada 2),5),6) Shinji Fukuda2),4),6),7),8)

    1)Research and Development Headquarters, 2)Metabologenomics, Inc.,3)Hiyoshi Oral Health Clinics. ,4)Institute for Advanced Biosciences, Keio University,5)Department of Life Science and Technology, Tokyo Institute of Technology, 6)PRESTO, Japan Science and Technology Agency,8)Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, 8)Transborder Medical Research Center, University of Tsukuba,

  • Direct-to-consumer genetic testing data identified the possible risk markers associated with the oral cavity health among Japanese subjects.

    American Society of Human Genetics 2019 Annual Meeting

    2019/10/15-10/19

    Satoshi Morishita

  • Improvement of Mechanical Toughness of Polypropylene by Laminating with Elastomer

    Journal of Polymer Research volume 26, Article number: 246 (2019)

    2019/9/12

    Ryosuke Hachisuka 1)2), Toshiaki Kobayashi 3), Masayuki Yamaguchi 2)

    1)School of Materials Science, Japan Advanced Institute of Science and Technology,2)Research & Development Headquarters, Lion Corporation, 3)The Lion Foundation for Dental Health, (Public Interest Incorporated Foundation)

  • A New Method to Speculate Halitosis Level Using Machine Learning

    International Association for Dental Research (IADR)

    2019/6/19-6/22

    Chiaki Michibayashi

  • Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts―in vitro study

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • The Journal of Japanese Society of Periodontology, 2019 Journal Award
    「Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study」

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2019 Volume61 Issue1 Pages 18-27

    2019/3/29

    Naho Suzuki

  • A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

    Scientific Reports 9, Article number: 3559 (2019)

    2019/3/5

    Takuya Hayakawa 1), Shizuka Kawasaki 1), Yutaka Hirayama 1),Takuya Tsutsui 1), Eiji Sugiyama 2), Kiyo Adachi 1), Ryo Kon 1), Makoto Suematsu 2), Yuki Sugiura 2)

    1)Research & Development Headquarters, Lion Corporation, 2)Department of Biochemistry, Keio University School of Medicine,

  • Importance of approaches to the host's defense mechanism in the prevention of periodontal disease and the effects of vitamin E

    The 149th Meeting of the Japanese Society of Conservative Dentistry

    2018/11/1

    Mari Yutori

  • Effects of copper gluconate on oral malodor

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Masato Takahashi

  • The wound healing effect of vitamin-E on human gingival fibroblasts

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Mari Yutori

  • Evaluation of vitamin-E permeability using human three-dimensional culture epidermis model

    The 61st Autumn Meeting of the Japanese Society of Periodontology

    2018/10/26-10/27

    Kazuaki Kojima

  • Technologies supporting oral care products

    The 60th Annual Meeting of Japanese Association for Oral Biology

    2018/9/5-9/7

    Mari Yutori

  • Effects of sodium polyacrylate on periodontal disease biofilm in vitro

    The 61st Spring Meeting of the Japanese Society of Periodontology

    2018/6/1-6/2

    Yusuke Kawanobe

  • THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR
    Excellent scientific papers First Class
    「Decomposition and removal of dental model plaque by using toothpaste containing dextranase」

    THE 2nd INTERNATIONAL ORAL CARE TECHNICAL SEMINAR

    2018/4/12

    Yuko Aoki 1), Gotaro Izumi 1), Yasuo Nomura 1), Ken-ichiro Shibasaki 1), 刘婧 2), 李德豹 2), 安丰宝 2) ,郑苏江 3)

    1)Lion Corporation
    2)獅王日用化工(青島)有限公司
    3)中国科学院理化技術研究所

  • Analysis of oral microbiome formation process in infancy

    The 91st Anuual Meeting of Japanese Society for Bacteriology

    2018/3/27-3/29

    Ryutaro Jo

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