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Our Research: Basic Technology Research

Oral Technology

Eating, speaking, laughing—these and other functions of the mouth are crucial to our ability to live comfortably and enjoyably. Lion’s oral science research goes back more than a century. Aiming to improve consumers’ quality of life (QOL), we continue to build on this wealth of knowledge with research in such areas as non-destructive methods of treating dental caries, ways to reduce gingival inflammation based on molecular cytology, and the suppression of bacterial growth using proprietary biofilm models. In recent years, Lion has also partnered with external research institutions to elucidate the influence that conditions in the oral cavity have on the body’s overall health through joint research. By combining a wide range of technologies from in and outside the Lion Group, chiefly in the area of oral science, we strive to create new value through products ranging from those for oral care to food and pharmaceuticals.

R&D Case Study—Oral Technology

Research Accomplishment—Oral Technology

2022

  • Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

    Scientific Reports 2022 12, Article number:689
    2022/1/13
    Yuki Maruyama1), Yuichiro Nishimoto2), Kouta Umezawa3), Ryosuke Kawamata1),Yuko Ichiba1), KotaTsutsumi1), Mitsuo Kimura1), Shinnosuke Murakami2),4), Yasushi Kakizawa1),Takashi Kumagai3), TakujiYamada2),5) & Shinji Fukuda2),4),6),7)
    1) Research and Development Headquarters, Lion Corporation, 2) Metabologenomics, Inc., 3) Hiyoshi Oral Health Clinics, 4) Institute for Advanced Biosciences, Keio University, 5) Department of Life Science and Technology, 6) Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 7) Transborder Medical Research Center, University of Tsukuba

2021

  • Inactivation Effect of Toothpaste on New Coronavirus (SARS-CoV-2) and Its Mechanism

    Annual Meeting of Japanese Society of Public Health
    2021/12/21-12/23
    Yukari Sekine
  • A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey

    BMC Oral Health
    2021/12/15
    Shinsuke Kataoka1), Mitsuo Kimura1),Tsuguno Yamaguchi1), Kenji Egashira1),Yu Yamamoto1), Yasushi Koike1),Yuki Ogawa1), Chika Fujiharu2), Toshiko Namai2), Kanako Taguchi2), Momoko Takahashi2), Asami Kameda2), Tomoka Kasen2),Asami Hano2), Konomi Kubota2),Masayuki Sato1), Hiroaki Yamaga1), Kaori Nohara2), Mikiko Shirasawa2), Chika Sekine2), Maki Fukuda2), Arisa Aoki2),Yurina Takeuchi2), Misaki Mugiyama2), Kenta Mori4), Keigo Sawada 4) Yoichiro Kashiwagi4), Masahiro Kitamura4), Takeshi Hayashi3),Tohru Nakagawa3), Shinya Murakami4)
    1) Research & Development Head Quarters, LION Corporation,2) The LION Foundation for Dental Health (Public Interest Incorporated Foundation), 3) Hitachi Health Care Center, Hitachi Limited,4) Faculty of Dentistry, Osaka University
  • Investigation of a novel technique for controlling the retention and sustained release of fluoride in the oral cavity

    The Japanese Society of Conservative Dentistry
    2021/10/28-11/10
    Masakazu Ono
  • Why Safety Toothbrushes That Don't Bend or Wiggle Can Brush Without Breaking ~The secret behind the toothbrush was born out of the desire to prevent children's throat-piercing accidents.

    Japanese Society of Pediatric Dentistry
    2021/10/17-10/23
    Ryosuke Hachisuka
  • Analysis of the effect of active ingredients of medicated toothpaste on RANKL-induced osteoclast differentiation

    The 64st Autumn Meeting of the Japanese Society of Periodontology
    2021/10/15-10/16
    Yu Yamamoto
  • Analysis of Major Oral Bacterial Changes from Birth to 36 Months of Age Using Next Generation Sequencers

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Yama Kazuma
  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Riho Makino
  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    Japanese Association for Oral Biology
    2021/10/9-10/11
    Mari Yutori
  • The inhibitory effects of toothpaste and mouthwash ingredients on SARS-CoV-2 spike protein-ACE2 interaction, and TMPRSS2 protease activity in vitro

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Taku Iwamoto
  • The Usefulness of an Oral-Health Promotion Program on Japanese Working-Age Population: A Pilot Study.

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Yukihide Aoyama
  • Oral care product flavors may prevent respiratory tract infections through promoting airway mucosal clearance

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Yasushi Koike
  • Potential role of oral care practices in preventing SARS-CoV-2 infection in the era of the “new normal”

    The 14th International Conference of Asian Academy of Preventive Dentistry
    2021/10/1-10/3
    Kota Tsutumi
  • The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro

    PLOS ONE
    2021/9/17
    Riho Tateyama-Makino1), Mari Abe-Yutori1), Taku Iwamoto1), Kota Tsutsumi1), Motonori Tsuji2),Satoru Morishita1), Kei Kurita1), Yukio Yamamoto1), Eiji Nishinaga1),Keiichi Tsukinoki3)
    1) Research & Development Headquarters, Lion Corporation, 2) Institute of Molecular Function, 3) Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University
  • Survey on oral care habits and halitosis among general community residents

    Annual Meeting of the Japanese Society for Oral Health Care
    2021/4/17-4/18
    Chiyoko Uchiyama
  • Inhibitory effects of toothpaste and mouthwash ingredients on the interaction between Sprotein of SARS-CoV-2 and ACE2

    The Chemical Society of Japan
    2021/3/19-3/21
    Mari Yutori
  • The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection

    The Chemical Society of Japan
    2021/3/19-3/21
    Riho Makino
  • The effect of aging on the nanostructure of murine alveolar bone and dentin

    Journal of Bone and Mineral Metabolism volume 39, pages757–768 (2021)
    2021/3/11
    Chika Akabane1),2), Silvia Pabisch2), Wolfgang Wagermaier2), Andreas Roschger2),3), Norio Tobori1), Tomomichi Okano1). Shinya Murakami4), Peter Fratzl2), Richard Weinkamer2)
    1) Research & Development Headquarters, Lion Corporation, 2) Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 3) Department of Chemistry and Physics of Materials, Paris-Lodron-University of Salzburg, Salzburg, Austria, 4) Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan
  • Comparison of oral microbiome profiles in 18-month-old infants and their parents

    Scientific Reports volume 11:861 (2021)
    2020/1/13
    Ryutaro Jo, Kazuma Yama, Yuto Aita, Kota Tsutsumi, Chikako Ishihara, Masato Maruyama, Eiji Nishinaga & Ken-ichiro Shibasaki
    Research and Development Headquarters, Lion Corporation
  • Material design of intelligent plastic products with sound generation function due to snap-through buckling

    Engineering Research Express, Volume 3.
    2021/1/11
    Ryosuke Hachisuka1),2), Reona Noda2), Masayuki Yamaguchi1)
    1) School of Materials Science, Japan Advanced Institute of Science and Technology, 2) Research & Development Headquarters,Lion Corporation
  • Basic study on staining and removal of dentin by various beverages

    Japanese Society for Oral Health
    Ayaka Iwasaki

2020

  • Development of Clinica NEXT STAGE toothbrush

    Packaging Technology
    2020/12/1
    Reona Noda, Shizuka Kawasaki, Ryosuke Hachisuka
  • Oral checkup with health guidance promoted changes in oral health behavior of examinees in a workplace.

    Japanese Society for Oral Health
    2020/10/20-10/22
    Koichiro Hayashi
  • The Effect of Bile Salts/Phospholipid Mixed Solutions on the Morphology of Giant Unilamellar Vesicles

    Japan Academy of Esthetic Dentistry
    202010/3-10/4
    Ryota Hashimoto
  • Development of “RePERO”, an application to support breath care

    The Division of Colloid and Surface Chemistry, The Chemical Society of Japan
    2020/9/13-9/16
    Kengo Oka
  • Self-care products:Functions and usefulness of fluoride toothpaste

    Society of dental Prctice administration
    2020/9/13
    Kenichiro Shibasaki
  • Reachability beyond the last molar and dental plaque removal ability of markedly thin-headed, slim-necked toothbrushes

    International Conference on Oral Protection Science
    2020/7/21-7/24
    Yuya Kimoto
  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    The Japanese Society of Conservative Dentistry
    2020/6/11-6/12
    Rika Oda
  • Effects of Phellodendron Bark Extract on RANKL-induced osteoclastogenesis

    the 63rd Spring Meeting of the Japanese Society of Periodontology
    2020/5/29-5/30
    Kenji Egashira
  • A Study on the Brushing Skill of a New Children's IoT Toothbrush Featuring Tooth Brushing Navigation

    Japanese Society of Pediatric Dentistry
    2020/5/20-5/21
    Mai Satake
  • Gingiva-specific Collagen Gene Regulation by Oxidative Stress

    International Association for Dental Research (IADR) 2020
    2020/3/18-3/21
    Tsuguno Yamagushi
  • Fluoride and Caries Prevention

    Tokyo Medical and Dental University
    2020/3/11
    Eiji Nishinaga
  • Effects of aluminum lactate and cationic cellulose containing Tooth Paste on sealing dentinal tubules

    THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY
    2020/1/7
    Shiori Ishii, Mari Imazaki, Sara Isurugi, Haruhiko Fujikawa, Yasushi Fukuda, Eiji Nishinaga

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